Hepatic iron overload following liver transplantation of a C282y homozygous allograft: a case report and literature review.

Hdl Handle:
http://hdl.handle.net/10147/217651
Title:
Hepatic iron overload following liver transplantation of a C282y homozygous allograft: a case report and literature review.
Authors:
Dwyer, Jeremy P; Sarwar, Shahzad; Egan, Brian; Nolan, Niamh; Hegarty, John
Affiliation:
Liver Unit, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Citation:
Hepatic iron overload following liver transplantation of a C282y homozygous allograft: a case report and literature review. 2011, 31 (10):1589-92 Liver Int.
Journal:
Liver international : official journal of the International Association for the Study of the Liver
Issue Date:
Nov-2011
URI:
http://hdl.handle.net/10147/217651
DOI:
10.1111/j.1478-3231.2011.02606.x
PubMed ID:
22093334
Abstract:
Hereditary haemochromatosis is a common genetic disease associated with progressive iron overload and parenchymal organ damage including liver, pancreas and heart. We report a case of inadvertent transplantation of a liver from a haemochromatosis donor to a 56-year-old Asian female. Progressive iron overload occurred over a 2 year follow up as assessed by liver biopsy and iron studies in the absence of a secondary cause of iron overload, supporting a primary role of liver rather than small intestine in the regulation of iron homeostasis in hereditary haemochromatosis.
Language:
en
MeSH:
Amino Acid Substitution; Biopsy, Needle; Female; Ferritins; Hemochromatosis; Histocompatibility Antigens Class I; Homeostasis; Humans; Iron; Liver Transplantation; Membrane Proteins; Middle Aged; Necrosis; Phlebotomy; Tissue Donors
ISSN:
1478-3231
Ethical Approval:
N/A

Full metadata record

DC FieldValue Language
dc.contributor.authorDwyer, Jeremy P-
dc.contributor.authorSarwar, Shahzad-
dc.contributor.authorEgan, Brian-
dc.contributor.authorNolan, Niamh-
dc.contributor.authorHegarty, John-
dc.date.accessioned2012-04-04T11:13:05Z-
dc.date.available2012-04-04T11:13:05Z-
dc.date.issued2011-11-
dc.identifier.citationHepatic iron overload following liver transplantation of a C282y homozygous allograft: a case report and literature review. 2011, 31 (10):1589-92 Liver Int.-
dc.identifier.issn1478-3231-
dc.identifier.pmid22093334-
dc.identifier.doi10.1111/j.1478-3231.2011.02606.x-
dc.identifier.urihttp://hdl.handle.net/10147/217651-
dc.description.abstractHereditary haemochromatosis is a common genetic disease associated with progressive iron overload and parenchymal organ damage including liver, pancreas and heart. We report a case of inadvertent transplantation of a liver from a haemochromatosis donor to a 56-year-old Asian female. Progressive iron overload occurred over a 2 year follow up as assessed by liver biopsy and iron studies in the absence of a secondary cause of iron overload, supporting a primary role of liver rather than small intestine in the regulation of iron homeostasis in hereditary haemochromatosis.-
dc.language.isoen-
dc.rightsArchived with thanks to Liver international : official journal of the International Association for the Study of the Liveren_GB
dc.subject.meshAmino Acid Substitution-
dc.subject.meshBiopsy, Needle-
dc.subject.meshFemale-
dc.subject.meshFerritins-
dc.subject.meshHemochromatosis-
dc.subject.meshHistocompatibility Antigens Class I-
dc.subject.meshHomeostasis-
dc.subject.meshHumans-
dc.subject.meshIron-
dc.subject.meshLiver Transplantation-
dc.subject.meshMembrane Proteins-
dc.subject.meshMiddle Aged-
dc.subject.meshNecrosis-
dc.subject.meshPhlebotomy-
dc.subject.meshTissue Donors-
dc.titleHepatic iron overload following liver transplantation of a C282y homozygous allograft: a case report and literature review.en_GB
dc.contributor.departmentLiver Unit, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.-
dc.identifier.journalLiver international : official journal of the International Association for the Study of the Liver-
dc.type.qualificationlevelN/Aen
cr.approval.ethicalN/Aen
dc.description.provinceLeinsteren
dc.description.provinceLeinster-

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