Clinical associations with a placental diagnosis of delayed villous maturation: a retrospective study.

Hdl Handle:
http://hdl.handle.net/10147/217193
Title:
Clinical associations with a placental diagnosis of delayed villous maturation: a retrospective study.
Authors:
Higgins, Mary; McAuliffe, Fionnuala M; Mooney, Eoghan E
Affiliation:
School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Citation:
Clinical associations with a placental diagnosis of delayed villous maturation: a retrospective study., 14 (4):273-9 Pediatr. Dev. Pathol.
Journal:
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
URI:
http://hdl.handle.net/10147/217193
DOI:
10.2350/10-07-0872-OA.1
PubMed ID:
21329421
Abstract:
Delayed villous maturation (DVM) is a spectrum of placental disease characterized by decreased tertiary villus formation, reduced vasculosyncytial membrane formation, and, in its more severe forms, increased large bullous villi. In some series it has been associated with an increased risk of stillbirth in the late third trimester, but overall there are few data on its significance. The aim of this study was to assess perinatal factors associated with, and the clinical significance of, the finding of DVM on placental histology. This was a retrospective study investigating all pregnancies with DVM diagnosed on placental histology in a tertiary level unit between December 2001 and August 2006. Over a 6-year period, 2915 placentas were triaged for histopathological assessment, representing 6.1% of all 48 054 deliveries in this time period. One hundred ninety (6.3%) of these selected cases showed DVM. Fifteen placentas from infants with less than 34 completed weeks of gestation were excluded, leaving 175 for further analysis. When compared with controls matched for gestation and delivering within the same time period (n  =  175), DVM was significantly associated with pregestational diabetes (8% vs 2.8%, P < .05; relative risk 2.8 [95% confidence interval 1.03-7.6]), gestational diabetes (8.6% vs 3.4%, P < 0.05; relative risk 2.5 [95% confidence interval 0.99-6.3]), and prenatal or intrapartum intrauterine death (8.6% vs 0%, P < 0.05). Delayed villous maturation is associated with both gestational and pregestational diabetes mellitus and with perinatal death.
Language:
en
MeSH:
Chorionic Villi; Diabetes Mellitus; Diabetes, Gestational; Female; Humans; Perinatal Mortality; Placenta Diseases; Pregnancy; Retrospective Studies
ISSN:
1093-5266
Ethical Approval:
N/A

Full metadata record

DC FieldValue Language
dc.contributor.authorHiggins, Mary-
dc.contributor.authorMcAuliffe, Fionnuala M-
dc.contributor.authorMooney, Eoghan E-
dc.date.accessioned2012-03-30T13:51:05Z-
dc.date.available2012-03-30T13:51:05Z-
dc.identifier.citationClinical associations with a placental diagnosis of delayed villous maturation: a retrospective study., 14 (4):273-9 Pediatr. Dev. Pathol.-
dc.identifier.issn1093-5266-
dc.identifier.pmid21329421-
dc.identifier.doi10.2350/10-07-0872-OA.1-
dc.identifier.urihttp://hdl.handle.net/10147/217193-
dc.description.abstractDelayed villous maturation (DVM) is a spectrum of placental disease characterized by decreased tertiary villus formation, reduced vasculosyncytial membrane formation, and, in its more severe forms, increased large bullous villi. In some series it has been associated with an increased risk of stillbirth in the late third trimester, but overall there are few data on its significance. The aim of this study was to assess perinatal factors associated with, and the clinical significance of, the finding of DVM on placental histology. This was a retrospective study investigating all pregnancies with DVM diagnosed on placental histology in a tertiary level unit between December 2001 and August 2006. Over a 6-year period, 2915 placentas were triaged for histopathological assessment, representing 6.1% of all 48 054 deliveries in this time period. One hundred ninety (6.3%) of these selected cases showed DVM. Fifteen placentas from infants with less than 34 completed weeks of gestation were excluded, leaving 175 for further analysis. When compared with controls matched for gestation and delivering within the same time period (n  =  175), DVM was significantly associated with pregestational diabetes (8% vs 2.8%, P < .05; relative risk 2.8 [95% confidence interval 1.03-7.6]), gestational diabetes (8.6% vs 3.4%, P < 0.05; relative risk 2.5 [95% confidence interval 0.99-6.3]), and prenatal or intrapartum intrauterine death (8.6% vs 0%, P < 0.05). Delayed villous maturation is associated with both gestational and pregestational diabetes mellitus and with perinatal death.-
dc.language.isoen-
dc.rightsArchived with thanks to Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Societyen_GB
dc.subject.meshChorionic Villi-
dc.subject.meshDiabetes Mellitus-
dc.subject.meshDiabetes, Gestational-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshPerinatal Mortality-
dc.subject.meshPlacenta Diseases-
dc.subject.meshPregnancy-
dc.subject.meshRetrospective Studies-
dc.titleClinical associations with a placental diagnosis of delayed villous maturation: a retrospective study.en_GB
dc.contributor.departmentSchool of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland.-
dc.identifier.journalPediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society-
dc.type.qualificationlevelN/Aen
cr.approval.ethicalN/Aen
dc.description.provinceLeinsteren
dc.description.provinceLeinster-

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