Villitis of unknown aetiology: correlation of recurrence with clinical outcome.

Hdl Handle:
http://hdl.handle.net/10147/217185
Title:
Villitis of unknown aetiology: correlation of recurrence with clinical outcome.
Authors:
Feeley, L; Mooney, E E
Affiliation:
Department of Pathology and Laboratory Medicine, National Maternity Hospital, Dublin, Ireland.
Citation:
Villitis of unknown aetiology: correlation of recurrence with clinical outcome. 2010, 30 (5):476-9 J Obstet Gynaecol
Journal:
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Issue Date:
2010
URI:
http://hdl.handle.net/10147/217185
DOI:
10.3109/01443611003802339
PubMed ID:
20604650
Abstract:
Villitis of unknown aetiology (VUA) is associated with adverse pregnancy outcome. Consequently, an ability to predict recurrence could be clinically relevant. We examined placentas where villitis was diagnosed in a previous pregnancy to establish the risk of recurrence and outcome. A total of 304 cases of VUA were diagnosed in our laboratory over a 4-year period. Subsequently, 19 of this cohort had a second placenta examined histologically. Recurrence and clinical outcome were recorded. Villitis recurred in 7 of 19 cases (37%). There was a high level of adverse pregnancy outcome in this cohort overall, characterised by small for gestational age infants and stillbirth, particularly in cases with high-grade villitis. We identified recurrent villitis more frequently than previously reported. Our findings confirm an association between high-grade villitis and poor outcome. Adequately powered prospective studies are required to determine if enhanced surveillance of subsequent pregnancies is indicated following a diagnosis of villitis.
Language:
en
MeSH:
Birth Weight; Chorionic Villi; Cohort Studies; Female; Humans; Infant, Newborn; Inflammation; Male; Placenta Diseases; Pregnancy; Pregnancy Outcome; Recurrence; Risk Factors
ISSN:
1364-6893
Ethical Approval:
N/A

Full metadata record

DC FieldValue Language
dc.contributor.authorFeeley, L-
dc.contributor.authorMooney, E E-
dc.date.accessioned2012-03-30T13:59:35Z-
dc.date.available2012-03-30T13:59:35Z-
dc.date.issued2010-
dc.identifier.citationVillitis of unknown aetiology: correlation of recurrence with clinical outcome. 2010, 30 (5):476-9 J Obstet Gynaecol-
dc.identifier.issn1364-6893-
dc.identifier.pmid20604650-
dc.identifier.doi10.3109/01443611003802339-
dc.identifier.urihttp://hdl.handle.net/10147/217185-
dc.description.abstractVillitis of unknown aetiology (VUA) is associated with adverse pregnancy outcome. Consequently, an ability to predict recurrence could be clinically relevant. We examined placentas where villitis was diagnosed in a previous pregnancy to establish the risk of recurrence and outcome. A total of 304 cases of VUA were diagnosed in our laboratory over a 4-year period. Subsequently, 19 of this cohort had a second placenta examined histologically. Recurrence and clinical outcome were recorded. Villitis recurred in 7 of 19 cases (37%). There was a high level of adverse pregnancy outcome in this cohort overall, characterised by small for gestational age infants and stillbirth, particularly in cases with high-grade villitis. We identified recurrent villitis more frequently than previously reported. Our findings confirm an association between high-grade villitis and poor outcome. Adequately powered prospective studies are required to determine if enhanced surveillance of subsequent pregnancies is indicated following a diagnosis of villitis.-
dc.language.isoen-
dc.rightsArchived with thanks to Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecologyen_GB
dc.subject.meshBirth Weight-
dc.subject.meshChorionic Villi-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshInflammation-
dc.subject.meshMale-
dc.subject.meshPlacenta Diseases-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy Outcome-
dc.subject.meshRecurrence-
dc.subject.meshRisk Factors-
dc.titleVillitis of unknown aetiology: correlation of recurrence with clinical outcome.en_GB
dc.contributor.departmentDepartment of Pathology and Laboratory Medicine, National Maternity Hospital, Dublin, Ireland.-
dc.identifier.journalJournal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology-
dc.type.qualificationlevelN/Aen
cr.approval.ethicalN/Aen
dc.description.provinceLeinsteren
dc.description.provinceLeinster-

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