Viral screening of couples undergoing partner donation in assisted reproduction with regard to EU Directives 2004/23/EC, 2006/17/EC and 2006/86/EC: what is the evidence for repeated screening?

Hdl Handle:
http://hdl.handle.net/10147/217183
Title:
Viral screening of couples undergoing partner donation in assisted reproduction with regard to EU Directives 2004/23/EC, 2006/17/EC and 2006/86/EC: what is the evidence for repeated screening?
Authors:
Wingfield, M; Cottell, E
Affiliation:
Merrion Fertility Clinic, National Maternity Hospital, Dublin, Ireland. mwingfield@nmh.ie
Citation:
Viral screening of couples undergoing partner donation in assisted reproduction with regard to EU Directives 2004/23/EC, 2006/17/EC and 2006/86/EC: what is the evidence for repeated screening? 2010, 25 (12):3058-65 Hum. Reprod.
Journal:
Human reproduction (Oxford, England)
Issue Date:
Dec-2010
URI:
http://hdl.handle.net/10147/217183
DOI:
10.1093/humrep/deq261
PubMed ID:
20956268
Abstract:
This paper concerns the requirements of the EU Tissue and Cells Directives with regard to the biological screening of donors of reproductive cells which are to be used for partner donation.; We review the evidence regarding the risks of transmission of blood-borne viruses [hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV)] in the assisted reproductive technology (ART) setting. We document the experience in seven Irish ART clinics since the introduction of the legislation.; Even among those known to be HBV-, HCV- or HIV-positive, when current best practice ART procedures are employed for gamete and embryo processing, cross-contamination in the ART facility or horizontal or vertical transmission to a partner or neonate has never been documented. When samples are processed and high-security straws are used for cryopreservation, transmission of virus and cross-contamination in storage have not been reported.; While initial screening of those about to embark on ART treatment is good practice, we can find no medical or scientific evidence to support re-screening prior to each treatment cycle for individuals undergoing partner donation in ART. It would seem more appropriate to focus on risk reduction using a combination of initial baseline screening (with a reduced frequency of re-testing), appropriate sample processing and best possible containment systems for cryostorage.
Language:
en
MeSH:
Disease Transmission, Infectious; Female; HIV Infections; HIV-1; Hepacivirus; Hepatitis B virus; Hepatitis C; Humans; Infant, Newborn; Insemination, Artificial, Homologous; Male; Mass Screening; Pregnancy; Reproductive Techniques, Assisted; Virus Diseases
ISSN:
1460-2350
Ethical Approval:
N/A

Full metadata record

DC FieldValue Language
dc.contributor.authorWingfield, M-
dc.contributor.authorCottell, E-
dc.date.accessioned2012-03-30T13:58:21Z-
dc.date.available2012-03-30T13:58:21Z-
dc.date.issued2010-12-
dc.identifier.citationViral screening of couples undergoing partner donation in assisted reproduction with regard to EU Directives 2004/23/EC, 2006/17/EC and 2006/86/EC: what is the evidence for repeated screening? 2010, 25 (12):3058-65 Hum. Reprod.-
dc.identifier.issn1460-2350-
dc.identifier.pmid20956268-
dc.identifier.doi10.1093/humrep/deq261-
dc.identifier.urihttp://hdl.handle.net/10147/217183-
dc.description.abstractThis paper concerns the requirements of the EU Tissue and Cells Directives with regard to the biological screening of donors of reproductive cells which are to be used for partner donation.-
dc.description.abstractWe review the evidence regarding the risks of transmission of blood-borne viruses [hepatitis B (HBV), hepatitis C (HCV) and human immunodeficiency virus (HIV)] in the assisted reproductive technology (ART) setting. We document the experience in seven Irish ART clinics since the introduction of the legislation.-
dc.description.abstractEven among those known to be HBV-, HCV- or HIV-positive, when current best practice ART procedures are employed for gamete and embryo processing, cross-contamination in the ART facility or horizontal or vertical transmission to a partner or neonate has never been documented. When samples are processed and high-security straws are used for cryopreservation, transmission of virus and cross-contamination in storage have not been reported.-
dc.description.abstractWhile initial screening of those about to embark on ART treatment is good practice, we can find no medical or scientific evidence to support re-screening prior to each treatment cycle for individuals undergoing partner donation in ART. It would seem more appropriate to focus on risk reduction using a combination of initial baseline screening (with a reduced frequency of re-testing), appropriate sample processing and best possible containment systems for cryostorage.-
dc.language.isoen-
dc.rightsArchived with thanks to Human reproduction (Oxford, England)en_GB
dc.subject.meshDisease Transmission, Infectious-
dc.subject.meshFemale-
dc.subject.meshHIV Infections-
dc.subject.meshHIV-1-
dc.subject.meshHepacivirus-
dc.subject.meshHepatitis B virus-
dc.subject.meshHepatitis C-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshInsemination, Artificial, Homologous-
dc.subject.meshMale-
dc.subject.meshMass Screening-
dc.subject.meshPregnancy-
dc.subject.meshReproductive Techniques, Assisted-
dc.subject.meshVirus Diseases-
dc.titleViral screening of couples undergoing partner donation in assisted reproduction with regard to EU Directives 2004/23/EC, 2006/17/EC and 2006/86/EC: what is the evidence for repeated screening?en_GB
dc.contributor.departmentMerrion Fertility Clinic, National Maternity Hospital, Dublin, Ireland. mwingfield@nmh.ie-
dc.identifier.journalHuman reproduction (Oxford, England)-
dc.type.qualificationlevelN/Aen
cr.approval.ethicalN/Aen
dc.description.provinceLeinsteren
dc.description.provinceLeinster-

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