Stereology of the placenta in type 1 and type 2 diabetes.

Hdl Handle:
http://hdl.handle.net/10147/217180
Title:
Stereology of the placenta in type 1 and type 2 diabetes.
Authors:
Higgins, M; Felle, P; Mooney, E E; Bannigan, J; McAuliffe, F M
Affiliation:
UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland.
Citation:
Stereology of the placenta in type 1 and type 2 diabetes. 2011, 32 (8):564-9 Placenta
Journal:
Placenta
Issue Date:
Aug-2011
URI:
http://hdl.handle.net/10147/217180
DOI:
10.1016/j.placenta.2011.04.015
PubMed ID:
21621839
Abstract:
To assess by stereology the placental structure in type 1 (T1DM) and type 2 (T2DM) diabetic pregnancies compared to normal non-diabetic (ND) controls.; Prospective case control study. Placentae were sampled in a systematic random fashion. Stereological analysis was performed using a computerised stereology programme (Image Pro 6.2, Media Cybernetics, Inc, Silver Spring MD, USA). Participants were matched for gender of infant and mode of delivery.; Volume, length and surface area of placental components; clinical outcome.; Ten ND, eight T2DM and ten T1DM women consented to the study. There was no difference between the groups regarding maternal age, neonatal birth weight, or placental weight. On stereological examination, terminal villous volume was significantly increased in both diabetic groups compared to ND controls. Capillary volume and length was increased in T1DM pregnancies compared to ND and T2DM. Capillary length was increased in both diabetic groups compared to ND. When all diabetic groups were compared based on severity of glycaemia those with poor glycaemic control (HbA1c>7%) had higher placental capillary volume than those with good glycaemic control.; This study demonstrates an association between maternal diabetes and increased terminal villous volume. Additionally capillary volume and length is increased in the placentae of normally grown infants of T1DM diabetic mothers compared to non-diabetic controls. Maternal glycaemia appears to influence capillary, but not stromal, development. This suggests that factors other than glycaemia have a role in placental development in pre-gestational diabetes.
Language:
en
MeSH:
Adult; Blood Glucose; Capillaries; Case-Control Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Male; Placenta; Pregnancy; Pregnancy in Diabetics; Prospective Studies
ISSN:
1532-3102
Ethical Approval:
N/A

Full metadata record

DC FieldValue Language
dc.contributor.authorHiggins, M-
dc.contributor.authorFelle, P-
dc.contributor.authorMooney, E E-
dc.contributor.authorBannigan, J-
dc.contributor.authorMcAuliffe, F M-
dc.date.accessioned2012-03-30T13:49:59Z-
dc.date.available2012-03-30T13:49:59Z-
dc.date.issued2011-08-
dc.identifier.citationStereology of the placenta in type 1 and type 2 diabetes. 2011, 32 (8):564-9 Placenta-
dc.identifier.issn1532-3102-
dc.identifier.pmid21621839-
dc.identifier.doi10.1016/j.placenta.2011.04.015-
dc.identifier.urihttp://hdl.handle.net/10147/217180-
dc.description.abstractTo assess by stereology the placental structure in type 1 (T1DM) and type 2 (T2DM) diabetic pregnancies compared to normal non-diabetic (ND) controls.-
dc.description.abstractProspective case control study. Placentae were sampled in a systematic random fashion. Stereological analysis was performed using a computerised stereology programme (Image Pro 6.2, Media Cybernetics, Inc, Silver Spring MD, USA). Participants were matched for gender of infant and mode of delivery.-
dc.description.abstractVolume, length and surface area of placental components; clinical outcome.-
dc.description.abstractTen ND, eight T2DM and ten T1DM women consented to the study. There was no difference between the groups regarding maternal age, neonatal birth weight, or placental weight. On stereological examination, terminal villous volume was significantly increased in both diabetic groups compared to ND controls. Capillary volume and length was increased in T1DM pregnancies compared to ND and T2DM. Capillary length was increased in both diabetic groups compared to ND. When all diabetic groups were compared based on severity of glycaemia those with poor glycaemic control (HbA1c>7%) had higher placental capillary volume than those with good glycaemic control.-
dc.description.abstractThis study demonstrates an association between maternal diabetes and increased terminal villous volume. Additionally capillary volume and length is increased in the placentae of normally grown infants of T1DM diabetic mothers compared to non-diabetic controls. Maternal glycaemia appears to influence capillary, but not stromal, development. This suggests that factors other than glycaemia have a role in placental development in pre-gestational diabetes.-
dc.language.isoen-
dc.rightsArchived with thanks to Placentaen_GB
dc.subject.meshAdult-
dc.subject.meshBlood Glucose-
dc.subject.meshCapillaries-
dc.subject.meshCase-Control Studies-
dc.subject.meshDiabetes Mellitus, Type 1-
dc.subject.meshDiabetes Mellitus, Type 2-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshPlacenta-
dc.subject.meshPregnancy-
dc.subject.meshPregnancy in Diabetics-
dc.subject.meshProspective Studies-
dc.titleStereology of the placenta in type 1 and type 2 diabetes.en_GB
dc.contributor.departmentUCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland.-
dc.identifier.journalPlacenta-
dc.type.qualificationlevelN/Aen
cr.approval.ethicalN/Aen
dc.description.provinceLeinsteren
dc.description.provinceLeinster-

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