Cost-effectiveness of universal rotavirus vaccination in reducing rotavirus gastroenteritis in Ireland.

Hdl Handle:
http://hdl.handle.net/10147/217174
Title:
Cost-effectiveness of universal rotavirus vaccination in reducing rotavirus gastroenteritis in Ireland.
Authors:
Tilson, L; Jit, M; Schmitz, S; Walsh, C; Garvey, P; McKeown, P; Barry, M
Affiliation:
National Centre for Pharmacoeconomics, St. James' Hospital, Dublin 8, Ireland. ltilson@stjames.ie
Citation:
Cost-effectiveness of universal rotavirus vaccination in reducing rotavirus gastroenteritis in Ireland. 2011, 29 (43):7463-73 Vaccine
Journal:
Vaccine
Issue Date:
6-Oct-2011
URI:
http://hdl.handle.net/10147/217174
DOI:
10.1016/j.vaccine.2011.07.056
PubMed ID:
21821085
Abstract:
We evaluated the cost-effectiveness of universal infant rotavirus (RV) vaccination compared to current standard of care of "no vaccination". Two RV vaccines are currently licensed in Ireland: Rotarix and RotaTeq. A cohort model used in several European countries was adapted using Irish epidemiological, resource utilisation and cost data. The base case model considers the impact of Rotarix vaccination on health-related quality of life of children under five years old from a healthcare payer perspective. Other scenarios explored the use of RotaTeq, impact on one caregiver, on societal costs and on cases that do not seek medical attention. Cost was varied between the vaccine list price (€100/course) in the base case and an assumed tender price (€70/course). One-way and probabilistic sensitivity analyses were conducted. Implementing universal RV vaccination may prevent around 1970 GP visits, 3280 A&E attendances and 2490 hospitalisations. A vaccination programme was estimated to cost approximately €6.54 million per year but €4.65 million of this would be offset by reducing healthcare resource use. The baseline ICER was €112,048/QALY and €72,736/QALY from the healthcare payer and societal perspective, respectively, falling to €68,896 and €43,916/QALY, respectively, if the impact on one caregiver was considered. If the price fell to €70 per course, universal RV vaccination would be cost saving under all scenarios. Results were sensitive to vaccination costs, incidence of RV infection and direct medical costs. Universal RV vaccination would not be cost-effective under base case assumptions. However, it could be cost-effective at a lower vaccine price or from a wider societal perspective.
Language:
en
MeSH:
Child, Preschool; Cost-Benefit Analysis; Gastroenteritis; Humans; Infant; Ireland; Quality of Life; Rotavirus; Rotavirus Infections; Rotavirus Vaccines
ISSN:
1873-2518
Ethical Approval:
N/A

Full metadata record

DC FieldValue Language
dc.contributor.authorTilson, L-
dc.contributor.authorJit, M-
dc.contributor.authorSchmitz, S-
dc.contributor.authorWalsh, C-
dc.contributor.authorGarvey, P-
dc.contributor.authorMcKeown, P-
dc.contributor.authorBarry, M-
dc.date.accessioned2012-03-30T13:12:46Z-
dc.date.available2012-03-30T13:12:46Z-
dc.date.issued2011-10-06-
dc.identifier.citationCost-effectiveness of universal rotavirus vaccination in reducing rotavirus gastroenteritis in Ireland. 2011, 29 (43):7463-73 Vaccine-
dc.identifier.issn1873-2518-
dc.identifier.pmid21821085-
dc.identifier.doi10.1016/j.vaccine.2011.07.056-
dc.identifier.urihttp://hdl.handle.net/10147/217174-
dc.description.abstractWe evaluated the cost-effectiveness of universal infant rotavirus (RV) vaccination compared to current standard of care of "no vaccination". Two RV vaccines are currently licensed in Ireland: Rotarix and RotaTeq. A cohort model used in several European countries was adapted using Irish epidemiological, resource utilisation and cost data. The base case model considers the impact of Rotarix vaccination on health-related quality of life of children under five years old from a healthcare payer perspective. Other scenarios explored the use of RotaTeq, impact on one caregiver, on societal costs and on cases that do not seek medical attention. Cost was varied between the vaccine list price (€100/course) in the base case and an assumed tender price (€70/course). One-way and probabilistic sensitivity analyses were conducted. Implementing universal RV vaccination may prevent around 1970 GP visits, 3280 A&E attendances and 2490 hospitalisations. A vaccination programme was estimated to cost approximately €6.54 million per year but €4.65 million of this would be offset by reducing healthcare resource use. The baseline ICER was €112,048/QALY and €72,736/QALY from the healthcare payer and societal perspective, respectively, falling to €68,896 and €43,916/QALY, respectively, if the impact on one caregiver was considered. If the price fell to €70 per course, universal RV vaccination would be cost saving under all scenarios. Results were sensitive to vaccination costs, incidence of RV infection and direct medical costs. Universal RV vaccination would not be cost-effective under base case assumptions. However, it could be cost-effective at a lower vaccine price or from a wider societal perspective.-
dc.language.isoen-
dc.rightsArchived with thanks to Vaccineen_GB
dc.subject.meshChild, Preschool-
dc.subject.meshCost-Benefit Analysis-
dc.subject.meshGastroenteritis-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshIreland-
dc.subject.meshQuality of Life-
dc.subject.meshRotavirus-
dc.subject.meshRotavirus Infections-
dc.subject.meshRotavirus Vaccines-
dc.titleCost-effectiveness of universal rotavirus vaccination in reducing rotavirus gastroenteritis in Ireland.en_GB
dc.contributor.departmentNational Centre for Pharmacoeconomics, St. James' Hospital, Dublin 8, Ireland. ltilson@stjames.ie-
dc.identifier.journalVaccine-
dc.type.qualificationlevelN/Aen
cr.approval.ethicalN/Aen
dc.description.provinceLeinster-
dc.description.provinceLeinsteren

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