Manganese toxicity with ephedrone abuse manifesting as parkinsonism: a case report

Hdl Handle:
http://hdl.handle.net/10147/215173
Title:
Manganese toxicity with ephedrone abuse manifesting as parkinsonism: a case report
Authors:
Iqbal, Mudassir; Monaghan, Thomas; Redmond, Janice
Citation:
Journal of Medical Case Reports. 2012 Feb 07;6(1):52
Issue Date:
7-Feb-2012
URI:
http://hdl.handle.net/10147/215173
Abstract:
Abstract Introduction Neurologic consequences of manganese toxicity have been recognized since 1837. A new form of presumed manganese poisoning has been reported in drug-addicted persons from Eastern Europe and the Baltic states who have intravenously injected self-prepared methcathinone hydrochloride (ephedrone), which is synthesized from pseudoephedrine hydrochloride using potassium permanganate as a potent oxidant. This clinical syndrome is under-recognized in Western Europe and there are no reported cases in the literature from Ireland. Case presentation We report a 30-year-old Eastern European man who presented with a two-year history of gait disturbance. A neurological assessment revealed features of parkinsonism which included hypophonia, hypomimia, mild bradykinesia and rigidity with no resting tremor. He held his arms slightly abducted from his sides when walking, with a reduction in arm swing. Magnetic resonance imaging of his brain showed a high signal on T1 in the globus pallidus and serum manganese levels were raised. He had no response to levodopa. Conclusion Manganism secondary to ephedrone abuse causing parkinsonism has emerged in Western Europe in recent years due to mass immigration and often remains unrecognized. This paper highlights the various features of this rare cause of parkinsonism and aids in its recognition and subsequent diagnosis. Neurologists in Western Europe will increasingly encounter such patients.
Item Type:
Journal Article

Full metadata record

DC FieldValue Language
dc.contributor.authorIqbal, Mudassir-
dc.contributor.authorMonaghan, Thomas-
dc.contributor.authorRedmond, Janice-
dc.date.accessioned2012-03-09T14:30:53Z-
dc.date.available2012-03-09T14:30:53Z-
dc.date.issued2012-02-07-
dc.identifierhttp://dx.doi.org/10.1186/1752-1947-6-52-
dc.identifier.citationJournal of Medical Case Reports. 2012 Feb 07;6(1):52-
dc.identifier.urihttp://hdl.handle.net/10147/215173-
dc.description.abstractAbstract Introduction Neurologic consequences of manganese toxicity have been recognized since 1837. A new form of presumed manganese poisoning has been reported in drug-addicted persons from Eastern Europe and the Baltic states who have intravenously injected self-prepared methcathinone hydrochloride (ephedrone), which is synthesized from pseudoephedrine hydrochloride using potassium permanganate as a potent oxidant. This clinical syndrome is under-recognized in Western Europe and there are no reported cases in the literature from Ireland. Case presentation We report a 30-year-old Eastern European man who presented with a two-year history of gait disturbance. A neurological assessment revealed features of parkinsonism which included hypophonia, hypomimia, mild bradykinesia and rigidity with no resting tremor. He held his arms slightly abducted from his sides when walking, with a reduction in arm swing. Magnetic resonance imaging of his brain showed a high signal on T1 in the globus pallidus and serum manganese levels were raised. He had no response to levodopa. Conclusion Manganism secondary to ephedrone abuse causing parkinsonism has emerged in Western Europe in recent years due to mass immigration and often remains unrecognized. This paper highlights the various features of this rare cause of parkinsonism and aids in its recognition and subsequent diagnosis. Neurologists in Western Europe will increasingly encounter such patients.-
dc.titleManganese toxicity with ephedrone abuse manifesting as parkinsonism: a case report-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderIqbal et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2012-02-29T20:04:31Z-
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.