The impact of MRSA infection in the airways of children with cystic fibrosis; a case-control study.

Hdl Handle:
http://hdl.handle.net/10147/213549
Title:
The impact of MRSA infection in the airways of children with cystic fibrosis; a case-control study.
Authors:
Cox, D W; Kelly, C; Rush, R; O'Sullivan, N; Canny, G; Linnane, B
Affiliation:
Our Lady's Children's Hospital, Crumlin, Dublin 12. dcox@meddent.uwa.edu.au
Citation:
The impact of MRSA infection in the airways of children with cystic fibrosis; a case-control study., 104 (10):305-8 Ir Med J
Journal:
Irish medical journal
URI:
http://hdl.handle.net/10147/213549
PubMed ID:
22256443
Abstract:
The prevalence of Methicillin Resistant Staphylococcus Aureus (MRSA) in patients with Cystic Fibrosis (CF) has risen dramatically over the past 10 years. The clinical significance of MRSA in CF patients remains undetermined. We conducted a review of patients with CF infected with MRSA over a 10 year period at Our Lady's Children's Hospital, Crumlin between 1999 and 2009. We collected data from 24 patients infected with MRSA and 24 control patients without MRSA There was a significant difference between the two groups in the rate of decline in percentage FEV1 two years after MRSA infection (Difference: -17.4, 95% CI: -30.48, -4.31, p = 0.01). A similar trend was seen for FVC% and FEF25-75% predicted. This study suggests that persistent MRSA infection in the airways of children with CF is associated with diminished lung function two years post acquisition, when compared to a matched control cohort without MRSA.
Language:
en
MeSH:
Adolescent; Case-Control Studies; Child; Child, Preschool; Cystic Fibrosis; Female; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Prevalence; Respiratory Function Tests; Respiratory System; Staphylococcal Infections; Time
ISSN:
0332-3102
Ethical Approval:
N/A

Full metadata record

DC FieldValue Language
dc.contributor.authorCox, D W-
dc.contributor.authorKelly, C-
dc.contributor.authorRush, R-
dc.contributor.authorO'Sullivan, N-
dc.contributor.authorCanny, G-
dc.contributor.authorLinnane, B-
dc.date.accessioned2012-02-29T12:03:24Z-
dc.date.available2012-02-29T12:03:24Z-
dc.identifier.citationThe impact of MRSA infection in the airways of children with cystic fibrosis; a case-control study., 104 (10):305-8 Ir Med J-
dc.identifier.issn0332-3102-
dc.identifier.pmid22256443-
dc.identifier.urihttp://hdl.handle.net/10147/213549-
dc.description.abstractThe prevalence of Methicillin Resistant Staphylococcus Aureus (MRSA) in patients with Cystic Fibrosis (CF) has risen dramatically over the past 10 years. The clinical significance of MRSA in CF patients remains undetermined. We conducted a review of patients with CF infected with MRSA over a 10 year period at Our Lady's Children's Hospital, Crumlin between 1999 and 2009. We collected data from 24 patients infected with MRSA and 24 control patients without MRSA There was a significant difference between the two groups in the rate of decline in percentage FEV1 two years after MRSA infection (Difference: -17.4, 95% CI: -30.48, -4.31, p = 0.01). A similar trend was seen for FVC% and FEF25-75% predicted. This study suggests that persistent MRSA infection in the airways of children with CF is associated with diminished lung function two years post acquisition, when compared to a matched control cohort without MRSA.-
dc.language.isoen-
dc.subject.meshAdolescent-
dc.subject.meshCase-Control Studies-
dc.subject.meshChild-
dc.subject.meshChild, Preschool-
dc.subject.meshCystic Fibrosis-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMethicillin-Resistant Staphylococcus aureus-
dc.subject.meshPrevalence-
dc.subject.meshRespiratory Function Tests-
dc.subject.meshRespiratory System-
dc.subject.meshStaphylococcal Infections-
dc.subject.meshTime-
dc.titleThe impact of MRSA infection in the airways of children with cystic fibrosis; a case-control study.en
dc.contributor.departmentOur Lady's Children's Hospital, Crumlin, Dublin 12. dcox@meddent.uwa.edu.au-
dc.identifier.journalIrish medical journal-
dc.type.qualificationlevelN/Aen
cr.approval.ethicalN/Aen
dc.description.provinceLeinster-

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