Anti-beta2 glycoprotein 1 and the anti-phospholipid syndrome.

Hdl Handle:
http://hdl.handle.net/10147/209298
Title:
Anti-beta2 glycoprotein 1 and the anti-phospholipid syndrome.
Authors:
Keane, Pearse A; Ravikumar, Kesavan; O'shea, Susan I; Cleary, Philip E
Affiliation:
Department of Ophthalmology, Cork University Hospital, Cork, Ireland., pearsek@iol.ie
Citation:
Am J Ophthalmol. 2006 Oct;142(4):701-2.
Journal:
American journal of ophthalmology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209298
DOI:
10.1016/j.ajo.2006.04.048
PubMed ID:
17011877
Abstract:
PURPOSE: To describe a patient who presented with bilateral retinal vascular occlusion and the use of anti-beta2 glycoprotein 1 (GPI) antibody testing in the diagnosis of antiphospholipid syndrome. DESIGN: Observational case report. METHODS: Hematological investigations were performed on a 49-year-old man who presented with rapid onset of bilateral severe central retinal vein occlusion. RESULTS: Lupus anticoagulant and anticardiolipin antibody testing was negative. Markedly raised titers of anti-beta2 GPI antibodies were detected on two separate occasions. CONCLUSIONS: The raised titers of anti-beta2 GPI antibodies were considered to strongly suggest an underlying diagnosis of the antiphospholipid syndrome.
Language:
eng
MeSH:
Antibodies, Anticardiolipin/blood; Antiphospholipid Syndrome/*diagnosis; Apolipoproteins/*immunology; Autoantibodies/*blood; Blindness/pathology; Glycoproteins/*immunology; Humans; Lupus Coagulation Inhibitor/blood; Male; Middle Aged; Retinal Vein Occlusion/*diagnosis; beta 2-Glycoprotein I
ISSN:
0002-9394 (Print); 0002-9394 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorKeane, Pearse Aen_GB
dc.contributor.authorRavikumar, Kesavanen_GB
dc.contributor.authorO'shea, Susan Ien_GB
dc.contributor.authorCleary, Philip Een_GB
dc.date.accessioned2012-02-03T15:17:33Z-
dc.date.available2012-02-03T15:17:33Z-
dc.date.issued2012-02-03T15:17:33Z-
dc.identifier.citationAm J Ophthalmol. 2006 Oct;142(4):701-2.en_GB
dc.identifier.issn0002-9394 (Print)en_GB
dc.identifier.issn0002-9394 (Linking)en_GB
dc.identifier.pmid17011877en_GB
dc.identifier.doi10.1016/j.ajo.2006.04.048en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209298-
dc.description.abstractPURPOSE: To describe a patient who presented with bilateral retinal vascular occlusion and the use of anti-beta2 glycoprotein 1 (GPI) antibody testing in the diagnosis of antiphospholipid syndrome. DESIGN: Observational case report. METHODS: Hematological investigations were performed on a 49-year-old man who presented with rapid onset of bilateral severe central retinal vein occlusion. RESULTS: Lupus anticoagulant and anticardiolipin antibody testing was negative. Markedly raised titers of anti-beta2 GPI antibodies were detected on two separate occasions. CONCLUSIONS: The raised titers of anti-beta2 GPI antibodies were considered to strongly suggest an underlying diagnosis of the antiphospholipid syndrome.en_GB
dc.language.isoengen_GB
dc.subject.meshAntibodies, Anticardiolipin/blooden_GB
dc.subject.meshAntiphospholipid Syndrome/*diagnosisen_GB
dc.subject.meshApolipoproteins/*immunologyen_GB
dc.subject.meshAutoantibodies/*blooden_GB
dc.subject.meshBlindness/pathologyen_GB
dc.subject.meshGlycoproteins/*immunologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLupus Coagulation Inhibitor/blooden_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshRetinal Vein Occlusion/*diagnosisen_GB
dc.subject.meshbeta 2-Glycoprotein Ien_GB
dc.titleAnti-beta2 glycoprotein 1 and the anti-phospholipid syndrome.en_GB
dc.contributor.departmentDepartment of Ophthalmology, Cork University Hospital, Cork, Ireland., pearsek@iol.ieen_GB
dc.identifier.journalAmerican journal of ophthalmologyen_GB
dc.description.provinceMunster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.