A study of idiopathic generalised epilepsy in an Irish population.

Hdl Handle:
http://hdl.handle.net/10147/209290
Title:
A study of idiopathic generalised epilepsy in an Irish population.
Authors:
Mullins, G M; O'Sullivan, S S; Neligan, A; McCarthy, A; McNamara, B; Galvin, R J; Sweeney, B J
Affiliation:
Department of Neurology and Neurophysiology, Cork University Hospital, Cork,, Ireland. Megager@yahoo.com
Citation:
Seizure. 2007 Apr;16(3):204-10. Epub 2007 Jan 12.
Journal:
Seizure : the journal of the British Epilepsy Association
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209290
DOI:
10.1016/j.seizure.2006.12.007
PubMed ID:
17223580
Abstract:
Idiopathic generalised epilepsy (IGE) is subdivided into syndromes based on clinical and EEG features. PURPOSE: The aim of this study was to characterise all cases of IGE with supportive EEG abnormalities in terms of gender differences, seizure types reported, IGE syndromes, family history of epilepsy and EEG findings. We also calculated the limited duration prevalence of IGE in our cohort. METHODS: Data on abnormal EEGs were collected retrospectively from two EEG databases at two tertiary referral centres for neurology. Clinical information was obtained from EEG request forms, standardised EEG questionnaires and medical notes of patients. RESULTS: two hundred twenty-three patients met our inclusion criteria, 89 (39.9%) male and 134 (60.1%) females. Tonic clonic seizures were the most common seizure type reported, 162 (72.65%) having a generalised tonic clonic seizure (GTCS) at some time. IGE with GTCS only (EGTCSA) was the most common syndrome in our cohort being present in 94 patients (34 male, 60 female), with 42 (15 male, 27 female) patients diagnosed with Juvenile myoclonic epilepsy (JME), 23 (9 male, 14 female) with Juvenile absence epilepsy (JAE) and 20 (9 male, 11 female) with childhood absence epilepsy (CAE). EEG studies in all patients showed generalised epileptiform activity. CONCLUSIONS: More women than men were diagnosed with generalised epilepsy. Tonic clonic seizures were the most common seizure type reported. EGTCSA was the most frequent syndrome seen. Gender differences were evident for JAE and JME as previously reported and for EGTCSA, which was not reported to date, and reached statistical significance for EGTCA and JME.
Language:
eng
MeSH:
Adult; Aged; Aged, 80 and over; *Electroencephalography; Epilepsy, Generalized/classification/epidemiology/*physiopathology; Female; Humans; Ireland; Male; Middle Aged; Prevalence; Retrospective Studies; Seizures/*classification; Sex Distribution
ISSN:
1059-1311 (Print); 1059-1311 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMullins, G Men_GB
dc.contributor.authorO'Sullivan, S Sen_GB
dc.contributor.authorNeligan, Aen_GB
dc.contributor.authorMcCarthy, Aen_GB
dc.contributor.authorMcNamara, Ben_GB
dc.contributor.authorGalvin, R Jen_GB
dc.contributor.authorSweeney, B Jen_GB
dc.date.accessioned2012-02-03T15:17:20Z-
dc.date.available2012-02-03T15:17:20Z-
dc.date.issued2012-02-03T15:17:20Z-
dc.identifier.citationSeizure. 2007 Apr;16(3):204-10. Epub 2007 Jan 12.en_GB
dc.identifier.issn1059-1311 (Print)en_GB
dc.identifier.issn1059-1311 (Linking)en_GB
dc.identifier.pmid17223580en_GB
dc.identifier.doi10.1016/j.seizure.2006.12.007en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209290-
dc.description.abstractIdiopathic generalised epilepsy (IGE) is subdivided into syndromes based on clinical and EEG features. PURPOSE: The aim of this study was to characterise all cases of IGE with supportive EEG abnormalities in terms of gender differences, seizure types reported, IGE syndromes, family history of epilepsy and EEG findings. We also calculated the limited duration prevalence of IGE in our cohort. METHODS: Data on abnormal EEGs were collected retrospectively from two EEG databases at two tertiary referral centres for neurology. Clinical information was obtained from EEG request forms, standardised EEG questionnaires and medical notes of patients. RESULTS: two hundred twenty-three patients met our inclusion criteria, 89 (39.9%) male and 134 (60.1%) females. Tonic clonic seizures were the most common seizure type reported, 162 (72.65%) having a generalised tonic clonic seizure (GTCS) at some time. IGE with GTCS only (EGTCSA) was the most common syndrome in our cohort being present in 94 patients (34 male, 60 female), with 42 (15 male, 27 female) patients diagnosed with Juvenile myoclonic epilepsy (JME), 23 (9 male, 14 female) with Juvenile absence epilepsy (JAE) and 20 (9 male, 11 female) with childhood absence epilepsy (CAE). EEG studies in all patients showed generalised epileptiform activity. CONCLUSIONS: More women than men were diagnosed with generalised epilepsy. Tonic clonic seizures were the most common seizure type reported. EGTCSA was the most frequent syndrome seen. Gender differences were evident for JAE and JME as previously reported and for EGTCSA, which was not reported to date, and reached statistical significance for EGTCA and JME.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.mesh*Electroencephalographyen_GB
dc.subject.meshEpilepsy, Generalized/classification/epidemiology/*physiopathologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIrelanden_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshSeizures/*classificationen_GB
dc.subject.meshSex Distributionen_GB
dc.titleA study of idiopathic generalised epilepsy in an Irish population.en_GB
dc.contributor.departmentDepartment of Neurology and Neurophysiology, Cork University Hospital, Cork,, Ireland. Megager@yahoo.comen_GB
dc.identifier.journalSeizure : the journal of the British Epilepsy Associationen_GB
dc.description.provinceMunster-

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