Daily diurnal variation in admissions for ruptured abdominal aortic aneurysms.

Hdl Handle:
http://hdl.handle.net/10147/209276
Title:
Daily diurnal variation in admissions for ruptured abdominal aortic aneurysms.
Authors:
Killeen, Shane; Neary, Peter; O'Sullivan, Martin; Redmond, H P; Fulton, Gregory
Affiliation:
Department of Surgery, Cork University Hospital, Cork, Ireland., sdfkilleen@eircom.net
Citation:
World J Surg. 2007 Sep;31(9):1869-71. Epub 2007 Jun 15.
Journal:
World journal of surgery
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209276
DOI:
10.1007/s00268-007-9126-z
PubMed ID:
17571206
Abstract:
BACKGROUND: Many vascular events, such as myocardial infarction and cerebrovascular accident, demonstrate a circadian pattern of presentation. Blood pressure is intimately related to these pathologies and is the one physiological variable consistently associated with abdominal aortic aneurysm rupture. It also demonstrates a diurnal variation. The purpose of this study was to determine if rupture of an abdominal aortic aneurysm (RAAA) exhibits a diurnal variation. METHODS: A retrospective cohort-based study was performed to determine the timing of presentation of RAAA to the vascular unit of Cork University Hospital over a 15-year period. Time of admission, symptom onset, and co-morbidities such as hypertension were noted. Fournier's analysis and chi-squared analysis were performed. To ameliorate possible confounding factors, patients admitted with perforated peptic ulcers were examined in the same manner. RESULTS: A total of 148 cases of RAAA were identified, with a male preponderance (71.7% [124] male versus 29.3% [44] female patients) and a mean age of 74.4 +/- 7.2 years at presentation. 70.9% (105) were known to have hypertension, 52.2% (77) were current smokers, and 46.8% (69) were being treated for chronic obstructive airway disease (COAD). Time of symptom onset was recorded in 88.5% (131) of patients. There was a marked early morning peak in RAAA admissions, with the highest number of RAAA being admitted between 08.00 and 09.59. A second, smaller peak was observed at 14.00-15.59. These findings were suggestive of diurnal variation. [chi(2) =16.75, p < 0.003]. Some 40% (59) of patients were admitted between 00.00 and 06.00, an incidence significantly higher than for other time periods (06.00-12.00, 12.00-18.00, and 18.00-24.00) [chi(2) = 18.72; df = 3; p < 0.0003]. A significantly higher number of patients admitted between 00.00 and 06.00 were known hypertensives (chi(2) = 7.94; p < 0.05). CONCLUSIONS: The findings of this study suggest a distinct circadian pattern of presentation for RAAA. Systolic blood pressure has a circadian rhythm that mirrors this pattern of presentation. Our results further support the association between RAAA and hypertension, and they may also indicate that chronotropic blood pressure control combating the early-morning peak in systolic blood pressure may assist in the management of abdominal aortic aneurysms.
Language:
eng
MeSH:
Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal/*epidemiology; Aortic Rupture/*epidemiology; Chi-Square Distribution; *Circadian Rhythm; Cohort Studies; Female; Hospitals, University; Humans; Hypertension/epidemiology; Ireland/epidemiology; Logistic Models; Male; Patient Admission/*statistics & numerical data; Retrospective Studies; Risk Factors
ISSN:
0364-2313 (Print); 0364-2313 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorKilleen, Shaneen_GB
dc.contributor.authorNeary, Peteren_GB
dc.contributor.authorO'Sullivan, Martinen_GB
dc.contributor.authorRedmond, H Pen_GB
dc.contributor.authorFulton, Gregoryen_GB
dc.date.accessioned2012-02-03T15:16:56Z-
dc.date.available2012-02-03T15:16:56Z-
dc.date.issued2012-02-03T15:16:56Z-
dc.identifier.citationWorld J Surg. 2007 Sep;31(9):1869-71. Epub 2007 Jun 15.en_GB
dc.identifier.issn0364-2313 (Print)en_GB
dc.identifier.issn0364-2313 (Linking)en_GB
dc.identifier.pmid17571206en_GB
dc.identifier.doi10.1007/s00268-007-9126-zen_GB
dc.identifier.urihttp://hdl.handle.net/10147/209276-
dc.description.abstractBACKGROUND: Many vascular events, such as myocardial infarction and cerebrovascular accident, demonstrate a circadian pattern of presentation. Blood pressure is intimately related to these pathologies and is the one physiological variable consistently associated with abdominal aortic aneurysm rupture. It also demonstrates a diurnal variation. The purpose of this study was to determine if rupture of an abdominal aortic aneurysm (RAAA) exhibits a diurnal variation. METHODS: A retrospective cohort-based study was performed to determine the timing of presentation of RAAA to the vascular unit of Cork University Hospital over a 15-year period. Time of admission, symptom onset, and co-morbidities such as hypertension were noted. Fournier's analysis and chi-squared analysis were performed. To ameliorate possible confounding factors, patients admitted with perforated peptic ulcers were examined in the same manner. RESULTS: A total of 148 cases of RAAA were identified, with a male preponderance (71.7% [124] male versus 29.3% [44] female patients) and a mean age of 74.4 +/- 7.2 years at presentation. 70.9% (105) were known to have hypertension, 52.2% (77) were current smokers, and 46.8% (69) were being treated for chronic obstructive airway disease (COAD). Time of symptom onset was recorded in 88.5% (131) of patients. There was a marked early morning peak in RAAA admissions, with the highest number of RAAA being admitted between 08.00 and 09.59. A second, smaller peak was observed at 14.00-15.59. These findings were suggestive of diurnal variation. [chi(2) =16.75, p < 0.003]. Some 40% (59) of patients were admitted between 00.00 and 06.00, an incidence significantly higher than for other time periods (06.00-12.00, 12.00-18.00, and 18.00-24.00) [chi(2) = 18.72; df = 3; p < 0.0003]. A significantly higher number of patients admitted between 00.00 and 06.00 were known hypertensives (chi(2) = 7.94; p < 0.05). CONCLUSIONS: The findings of this study suggest a distinct circadian pattern of presentation for RAAA. Systolic blood pressure has a circadian rhythm that mirrors this pattern of presentation. Our results further support the association between RAAA and hypertension, and they may also indicate that chronotropic blood pressure control combating the early-morning peak in systolic blood pressure may assist in the management of abdominal aortic aneurysms.en_GB
dc.language.isoengen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshAortic Aneurysm, Abdominal/*epidemiologyen_GB
dc.subject.meshAortic Rupture/*epidemiologyen_GB
dc.subject.meshChi-Square Distributionen_GB
dc.subject.mesh*Circadian Rhythmen_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHospitals, Universityen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypertension/epidemiologyen_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshLogistic Modelsen_GB
dc.subject.meshMaleen_GB
dc.subject.meshPatient Admission/*statistics & numerical dataen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshRisk Factorsen_GB
dc.titleDaily diurnal variation in admissions for ruptured abdominal aortic aneurysms.en_GB
dc.contributor.departmentDepartment of Surgery, Cork University Hospital, Cork, Ireland., sdfkilleen@eircom.neten_GB
dc.identifier.journalWorld journal of surgeryen_GB
dc.description.provinceMunster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.