The immunomodulatory effects of laparoscopic surgery.

Hdl Handle:
http://hdl.handle.net/10147/209265
Title:
The immunomodulatory effects of laparoscopic surgery.
Authors:
Corrigan, Mark; Cahill, Ronan A; Redmond, Henry Paul
Affiliation:
Department of Academic Surgery, Cork University Hospital, Wilton, Cork, Ireland.
Citation:
Surg Laparosc Endosc Percutan Tech. 2007 Aug;17(4):256-61.
Journal:
Surgical laparoscopy, endoscopy & percutaneous techniques
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209265
DOI:
10.1097/SLE.0b013e318059b9c3
PubMed ID:
17710044
Abstract:
Laparoscopic alternatives to conventional surgical procedures confer many advantages to patients including reduced postoperative pain, shortened convalescence and, perhaps, improved disease-related outcomes. The diminished degree of immune dysfunction apparent with these techniques may underpin these beneficial aspects. However, minimal access is accompanied by various ancillary anesthetic and mechanical associations (including the induction of a carbon dioxide pneumoperitoneum), which must be considered in addition to reduced tissue trauma when attempting to correlate cause with effect. Furthermore, the opportunity to establish causation between the immunomodulatory aspects of laparoscopy and subsequent clinical outcome by prospective, randomized study is difficult because of the rapid incorporation of minimal access techniques into clinical practice. Therefore, experimental in vitro and in vivo studies must be used to complement the limitations of clinical studies in this area. Although the initial investigations into the immunological effects of laparoscopy are encouraging, many of the intricacies associated with this approach still await elaboration.
Language:
eng
MeSH:
Analgesics, Opioid/pharmacology; Anesthetics, Local/pharmacology; Antibody Formation; Carbon Dioxide/pharmacology; Cytokines/immunology; Humans; *Immunity, Cellular; Insufflation; *Laparoscopy; Pneumoperitoneum, Artificial; Postoperative Period; Tumor Necrosis Factor-alpha/metabolism
ISSN:
1530-4515 (Print); 1530-4515 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCorrigan, Marken_GB
dc.contributor.authorCahill, Ronan Aen_GB
dc.contributor.authorRedmond, Henry Paulen_GB
dc.date.accessioned2012-02-03T15:16:38Z-
dc.date.available2012-02-03T15:16:38Z-
dc.date.issued2012-02-03T15:16:38Z-
dc.identifier.citationSurg Laparosc Endosc Percutan Tech. 2007 Aug;17(4):256-61.en_GB
dc.identifier.issn1530-4515 (Print)en_GB
dc.identifier.issn1530-4515 (Linking)en_GB
dc.identifier.pmid17710044en_GB
dc.identifier.doi10.1097/SLE.0b013e318059b9c3en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209265-
dc.description.abstractLaparoscopic alternatives to conventional surgical procedures confer many advantages to patients including reduced postoperative pain, shortened convalescence and, perhaps, improved disease-related outcomes. The diminished degree of immune dysfunction apparent with these techniques may underpin these beneficial aspects. However, minimal access is accompanied by various ancillary anesthetic and mechanical associations (including the induction of a carbon dioxide pneumoperitoneum), which must be considered in addition to reduced tissue trauma when attempting to correlate cause with effect. Furthermore, the opportunity to establish causation between the immunomodulatory aspects of laparoscopy and subsequent clinical outcome by prospective, randomized study is difficult because of the rapid incorporation of minimal access techniques into clinical practice. Therefore, experimental in vitro and in vivo studies must be used to complement the limitations of clinical studies in this area. Although the initial investigations into the immunological effects of laparoscopy are encouraging, many of the intricacies associated with this approach still await elaboration.en_GB
dc.language.isoengen_GB
dc.subject.meshAnalgesics, Opioid/pharmacologyen_GB
dc.subject.meshAnesthetics, Local/pharmacologyen_GB
dc.subject.meshAntibody Formationen_GB
dc.subject.meshCarbon Dioxide/pharmacologyen_GB
dc.subject.meshCytokines/immunologyen_GB
dc.subject.meshHumansen_GB
dc.subject.mesh*Immunity, Cellularen_GB
dc.subject.meshInsufflationen_GB
dc.subject.mesh*Laparoscopyen_GB
dc.subject.meshPneumoperitoneum, Artificialen_GB
dc.subject.meshPostoperative Perioden_GB
dc.subject.meshTumor Necrosis Factor-alpha/metabolismen_GB
dc.titleThe immunomodulatory effects of laparoscopic surgery.en_GB
dc.contributor.departmentDepartment of Academic Surgery, Cork University Hospital, Wilton, Cork, Ireland.en_GB
dc.identifier.journalSurgical laparoscopy, endoscopy & percutaneous techniquesen_GB
dc.description.provinceMunster-

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