Reduced plasma aldosterone concentrations in randomly selected patients with insulin-dependent diabetes mellitus.

Hdl Handle:
http://hdl.handle.net/10147/209238
Title:
Reduced plasma aldosterone concentrations in randomly selected patients with insulin-dependent diabetes mellitus.
Authors:
Cronin, C C; Barry, D; Crowley, B; Ferriss, J B
Affiliation:
Department of Medicine, Cork University Hospital, Ireland.
Citation:
Diabet Med. 1995 Sep;12(9):809-15.
Journal:
Diabetic medicine : a journal of the British Diabetic Association
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209238
PubMed ID:
8542742
Abstract:
Abnormalities of the renin-angiotensin system have been reported in patients with diabetes mellitus and with diabetic complications. In this study, plasma concentrations of prorenin, renin, and aldosterone were measured in a stratified random sample of 110 insulin-dependent (Type 1) diabetic patients attending our outpatient clinic. Fifty-four age- and sex-matched control subjects were also examined. Plasma prorenin concentration was higher in patients without complications than in control subjects when upright (geometric mean (95% confidence intervals (CI): 75.9 (55.0-105.6) vs 45.1 (31.6-64.3) mU I-1, p < 0.05). There was no difference in plasma prorenin concentration between patients without and with microalbuminuria and between patients without and with background retinopathy. Plasma renin concentration, both when supine and upright, was similar in control subjects, in patients without complications, and in patients with varying degrees of diabetic microangiopathy. Plasma aldosterone was suppressed in patients without complications in comparison to control subjects (74 (58-95) vs 167 (140-199) ng I-1, p < 0.001) and was also suppressed in patients with microvascular disease. Plasma potassium was significantly higher in patients than in control subjects (mean +/- standard deviation: 4.10 +/- 0.36 vs 3.89 +/- 0.26 mmol I-1; p < 0.001) and plasma sodium was significantly lower (138 +/- 4 vs 140 +/- 2 mmol I-1; p < 0.001). We conclude that plasma prorenin is not a useful early marker for diabetic microvascular disease. Despite apparently normal plasma renin concentrations, plasma aldosterone is suppressed in insulin-dependent diabetic patients.
Language:
eng
MeSH:
Adolescent; Adult; Aldosterone/*blood; Ambulatory Care; Diabetes Mellitus, Type 1/*blood; Enzyme Precursors/*blood; Female; Humans; Male; Middle Aged; Renin/*blood
ISSN:
0742-3071 (Print); 0742-3071 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCronin, C Cen_GB
dc.contributor.authorBarry, Den_GB
dc.contributor.authorCrowley, Ben_GB
dc.contributor.authorFerriss, J Ben_GB
dc.date.accessioned2012-02-03T15:15:56Z-
dc.date.available2012-02-03T15:15:56Z-
dc.date.issued2012-02-03T15:15:56Z-
dc.identifier.citationDiabet Med. 1995 Sep;12(9):809-15.en_GB
dc.identifier.issn0742-3071 (Print)en_GB
dc.identifier.issn0742-3071 (Linking)en_GB
dc.identifier.pmid8542742en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209238-
dc.description.abstractAbnormalities of the renin-angiotensin system have been reported in patients with diabetes mellitus and with diabetic complications. In this study, plasma concentrations of prorenin, renin, and aldosterone were measured in a stratified random sample of 110 insulin-dependent (Type 1) diabetic patients attending our outpatient clinic. Fifty-four age- and sex-matched control subjects were also examined. Plasma prorenin concentration was higher in patients without complications than in control subjects when upright (geometric mean (95% confidence intervals (CI): 75.9 (55.0-105.6) vs 45.1 (31.6-64.3) mU I-1, p < 0.05). There was no difference in plasma prorenin concentration between patients without and with microalbuminuria and between patients without and with background retinopathy. Plasma renin concentration, both when supine and upright, was similar in control subjects, in patients without complications, and in patients with varying degrees of diabetic microangiopathy. Plasma aldosterone was suppressed in patients without complications in comparison to control subjects (74 (58-95) vs 167 (140-199) ng I-1, p < 0.001) and was also suppressed in patients with microvascular disease. Plasma potassium was significantly higher in patients than in control subjects (mean +/- standard deviation: 4.10 +/- 0.36 vs 3.89 +/- 0.26 mmol I-1; p < 0.001) and plasma sodium was significantly lower (138 +/- 4 vs 140 +/- 2 mmol I-1; p < 0.001). We conclude that plasma prorenin is not a useful early marker for diabetic microvascular disease. Despite apparently normal plasma renin concentrations, plasma aldosterone is suppressed in insulin-dependent diabetic patients.en_GB
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAldosterone/*blooden_GB
dc.subject.meshAmbulatory Careen_GB
dc.subject.meshDiabetes Mellitus, Type 1/*blooden_GB
dc.subject.meshEnzyme Precursors/*blooden_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshRenin/*blooden_GB
dc.titleReduced plasma aldosterone concentrations in randomly selected patients with insulin-dependent diabetes mellitus.en_GB
dc.contributor.departmentDepartment of Medicine, Cork University Hospital, Ireland.en_GB
dc.identifier.journalDiabetic medicine : a journal of the British Diabetic Associationen_GB
dc.description.provinceMunster-

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