Addison disease in patients treated with glucocorticoid therapy.

Hdl Handle:
http://hdl.handle.net/10147/209213
Title:
Addison disease in patients treated with glucocorticoid therapy.
Authors:
Cronin, C C; Callaghan, N; Kearney, P J; Murnaghan, D J; Shanahan, F
Affiliation:
Department of Medicine, Cork University Hospital, Ireland.
Citation:
Arch Intern Med. 1997 Feb 24;157(4):456-8.
Journal:
Archives of internal medicine
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209213
PubMed ID:
9046898
Abstract:
Acute adrenal crisis in patients with unrecognized chronic adrenocortical failure is difficult to diagnose and potentially fatal. We describe 2 patients with acute adrenal crisis whose diagnoses were hindered because of concomitant glucocorticoid treatment. Acute adrenal insufficiency is primarily a state of mineralocorticoid deficiency. Prednisolone and prednisone, the most frequently prescribed anti-inflammatory corticosteroid agents, have minimal mineralocorticoid activity. Several conditions that may be treated with pharmacological glucocorticoids are associated with an increased risk of Addison disease. An acute adrenal crisis, against which concurrent glucocorticoid therapy does not confer adequate protection, may develop in such patients.
Language:
eng
MeSH:
Acute Disease; Addison Disease/*diagnosis; Chronic Disease; Diagnosis, Differential; Female; Glucocorticoids/*therapeutic use; Humans; Infant; Male; Middle Aged
ISSN:
0003-9926 (Print); 0003-9926 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCronin, C Cen_GB
dc.contributor.authorCallaghan, Nen_GB
dc.contributor.authorKearney, P Jen_GB
dc.contributor.authorMurnaghan, D Jen_GB
dc.contributor.authorShanahan, Fen_GB
dc.date.accessioned2012-02-03T15:15:14Z-
dc.date.available2012-02-03T15:15:14Z-
dc.date.issued2012-02-03T15:15:14Z-
dc.identifier.citationArch Intern Med. 1997 Feb 24;157(4):456-8.en_GB
dc.identifier.issn0003-9926 (Print)en_GB
dc.identifier.issn0003-9926 (Linking)en_GB
dc.identifier.pmid9046898en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209213-
dc.description.abstractAcute adrenal crisis in patients with unrecognized chronic adrenocortical failure is difficult to diagnose and potentially fatal. We describe 2 patients with acute adrenal crisis whose diagnoses were hindered because of concomitant glucocorticoid treatment. Acute adrenal insufficiency is primarily a state of mineralocorticoid deficiency. Prednisolone and prednisone, the most frequently prescribed anti-inflammatory corticosteroid agents, have minimal mineralocorticoid activity. Several conditions that may be treated with pharmacological glucocorticoids are associated with an increased risk of Addison disease. An acute adrenal crisis, against which concurrent glucocorticoid therapy does not confer adequate protection, may develop in such patients.en_GB
dc.language.isoengen_GB
dc.subject.meshAcute Diseaseen_GB
dc.subject.meshAddison Disease/*diagnosisen_GB
dc.subject.meshChronic Diseaseen_GB
dc.subject.meshDiagnosis, Differentialen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGlucocorticoids/*therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfanten_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.titleAddison disease in patients treated with glucocorticoid therapy.en_GB
dc.contributor.departmentDepartment of Medicine, Cork University Hospital, Ireland.en_GB
dc.identifier.journalArchives of internal medicineen_GB
dc.description.provinceMunster-

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