Microalbuminuria in patients with non-insulin-dependent diabetes mellitus relates to nocturnal systolic blood pressure.
Affiliation
Department of Medicine and Biochemistry, Cork University Hospital, Wilton,, Ireland.Issue Date
2012-02-03T15:15:04ZMeSH
AdultAged
Albuminuria/etiology/*physiopathology
*Blood Pressure
Case-Control Studies
*Circadian Rhythm
Cross-Sectional Studies
Diabetes Mellitus, Type 2/complications/*physiopathology
Female
Humans
Male
Middle Aged
Regression Analysis
Systole
Metadata
Show full item recordCitation
Am J Med. 1997 Jun;102(6):531-5.Journal
The American journal of medicinePubMed ID
9217667Abstract
PURPOSE: Microalbuminuria predicts early mortality in non-insulin-dependent-diabetes mellitus patients (NIDDM). Our objective in the present study was to compare and assess the relationship between 24-hour, day and nocturnal ambulatory blood pressure (BP) and urinary albumin excretion rate (UAE) in microalbuminuric and normoalbuminuric NIDDM and in normal control subjects. PATIENTS AND METHODS: In the present cross-sectional study, 24 hour ambulatory BP (daytime BP and nocturnal BP) and HbA1c were compared in microalbuminuric (n = 10) and nonmicroalbuminuric NIDDM patients (n = 10) and in nondiabetic controls (n = 9). None of the patients were taking antihypertensive agents. RESULTS: In the microlbuminuric group, whereas 24 hour and daytime systolic BP differed significantly from control values (P < 0.025 and P < 0.05 respectively), there was no difference between diabetic groups. However, nocturnal systolic BP in the microalbuminuric group was significantly higher than in the normoalbuminuric diabetic patients (139 vs. 125) (P < 0.05) and a significant difference was also found between the NIDDM patients and the control group (139, 125 vs. 114) (P < 0.025). In multiple regression analysis, only nocturnal systolic BP showed a significant relationship with UAE (P < 0.05). CONCLUSIONS: We suggest that the higher nocturnal systolic blood pressure seen in our microalbuminuric NIDDM patients may contribute to the increased morbidity in this group.Language
engISSN
0002-9343 (Print)0002-9343 (Linking)