Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology.

Hdl Handle:
http://hdl.handle.net/10147/209163
Title:
Brain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology.
Authors:
Shanahan, F
Affiliation:
Department of Medicine, National University of Ireland, and Cork University, Hospital.
Citation:
Semin Gastrointest Dis. 1999 Jan;10(1):8-13.
Journal:
Seminars in gastrointestinal disease
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209163
PubMed ID:
10065767
Abstract:
The role of the brain-gut axis has traditionally been investigated in relation to intestinal motility, secretion, and vascularity. More recently, the concept of brain-gut dialogue has extended to the relationship between the nervous system and mucosal immune function. There is compelling evidence for a reciprocal or bi-directional communication between the immune system and the neuroendocrine system. This is mediated, in part, by shared ligands (chemical messengers) and receptors that are common to the immune and nervous systems. Although the concept of psychoneuroimmunology and neuroimmune cross-talk has been studied primarily in the context of the systemic immune system, it is likely to have special significance in the gut. The mucosal immune system is anatomically, functionally, and operationally distinct from the systemic immune system and is subject to independent regulatory signals. Furthermore, the intestinal mucosal immune system operates in a local milieu that depends on a dense innervation for its integrity, with juxtaposition of neuroendocrine cells and mucosal immune cells. An overview of evidence for the biologic plausibility of a brain-gut-immune axis is presented and its potential relevance to mucosal inflammatory disorders is discussed.
Language:
eng
MeSH:
Adult; Amputation/psychology; Arm Injuries/complications/psychology; Crohn Disease/complications/*immunology/*psychology/therapy; Humans; Immunity, Mucosal; Inflammatory Bowel Diseases/psychology; Male; Stress, Psychological
ISSN:
1049-5118 (Print); 1049-5118 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorShanahan, Fen_GB
dc.date.accessioned2012-02-03T15:13:56Z-
dc.date.available2012-02-03T15:13:56Z-
dc.date.issued2012-02-03T15:13:56Z-
dc.identifier.citationSemin Gastrointest Dis. 1999 Jan;10(1):8-13.en_GB
dc.identifier.issn1049-5118 (Print)en_GB
dc.identifier.issn1049-5118 (Linking)en_GB
dc.identifier.pmid10065767en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209163-
dc.description.abstractThe role of the brain-gut axis has traditionally been investigated in relation to intestinal motility, secretion, and vascularity. More recently, the concept of brain-gut dialogue has extended to the relationship between the nervous system and mucosal immune function. There is compelling evidence for a reciprocal or bi-directional communication between the immune system and the neuroendocrine system. This is mediated, in part, by shared ligands (chemical messengers) and receptors that are common to the immune and nervous systems. Although the concept of psychoneuroimmunology and neuroimmune cross-talk has been studied primarily in the context of the systemic immune system, it is likely to have special significance in the gut. The mucosal immune system is anatomically, functionally, and operationally distinct from the systemic immune system and is subject to independent regulatory signals. Furthermore, the intestinal mucosal immune system operates in a local milieu that depends on a dense innervation for its integrity, with juxtaposition of neuroendocrine cells and mucosal immune cells. An overview of evidence for the biologic plausibility of a brain-gut-immune axis is presented and its potential relevance to mucosal inflammatory disorders is discussed.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAmputation/psychologyen_GB
dc.subject.meshArm Injuries/complications/psychologyen_GB
dc.subject.meshCrohn Disease/complications/*immunology/*psychology/therapyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmunity, Mucosalen_GB
dc.subject.meshInflammatory Bowel Diseases/psychologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshStress, Psychologicalen_GB
dc.titleBrain-gut axis and mucosal immunity: a perspective on mucosal psychoneuroimmunology.en_GB
dc.contributor.departmentDepartment of Medicine, National University of Ireland, and Cork University, Hospital.en_GB
dc.identifier.journalSeminars in gastrointestinal diseaseen_GB
dc.description.provinceMunster-
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