Type 1 diabetes mellitus, coeliac disease, and lymphoma: a report of four cases.

Hdl Handle:
http://hdl.handle.net/10147/209146
Title:
Type 1 diabetes mellitus, coeliac disease, and lymphoma: a report of four cases.
Authors:
O'Connor, T M; Cronin, C C; Loane, J F; O'Meara, N M; Firth, R G; Shanahan, F; O'Halloran, D J
Affiliation:
Department of Medicine, Cork University Hospital, Wilton, Ireland., terryoconnor@tinet.ie
Citation:
Diabet Med. 1999 Jul;16(7):614-7.
Journal:
Diabetic medicine : a journal of the British Diabetic Association
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209146
PubMed ID:
10445840
Abstract:
INTRODUCTION: Patients with Type 1 diabetes mellitus have a high prevalence of coeliac disease, symptoms of which are often mild, atypical, or absent. Untreated coeliac disease is associated with an increased risk of malignancy, particularly of lymphoma. We describe four patients with Type 1 diabetes mellitus and coeliac disease who developed lymphoma. CASE REPORTS: Two patients were male and two female. In three patients, coeliac disease and lymphoma were diagnosed simultaneously. Enteropathy-associated T cell lymphoma occurred in two patients, Hodgkin's disease in one, and B cell lymphoma in one. Response to treatment was in general poor, and three patients died soon after the diagnosis of lymphoma was made. CONCLUSION: As the relative risk of lymphoma is reduced by a gluten-free diet, a high index of suspicion for coeliac disease should exist in all Type 1 diabetic patients with unexplained constitutional or gastrointestinal symptoms.
Language:
eng
MeSH:
Adult; Aged; Celiac Disease/*complications/*diagnosis; Diabetes Mellitus, Type 1/*complications/*diagnosis; Diabetic Ketoacidosis/diagnosis; Female; Hodgkin Disease/complications/diagnosis; Humans; Lymphoma/*complications/*diagnosis; Lymphoma, B-Cell/complications/diagnosis; Lymphoma, T-Cell/complications/diagnosis; Male; Middle Aged
ISSN:
0742-3071 (Print); 0742-3071 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Connor, T Men_GB
dc.contributor.authorCronin, C Cen_GB
dc.contributor.authorLoane, J Fen_GB
dc.contributor.authorO'Meara, N Men_GB
dc.contributor.authorFirth, R Gen_GB
dc.contributor.authorShanahan, Fen_GB
dc.contributor.authorO'Halloran, D Jen_GB
dc.date.accessioned2012-02-03T15:13:28Z-
dc.date.available2012-02-03T15:13:28Z-
dc.date.issued2012-02-03T15:13:28Z-
dc.identifier.citationDiabet Med. 1999 Jul;16(7):614-7.en_GB
dc.identifier.issn0742-3071 (Print)en_GB
dc.identifier.issn0742-3071 (Linking)en_GB
dc.identifier.pmid10445840en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209146-
dc.description.abstractINTRODUCTION: Patients with Type 1 diabetes mellitus have a high prevalence of coeliac disease, symptoms of which are often mild, atypical, or absent. Untreated coeliac disease is associated with an increased risk of malignancy, particularly of lymphoma. We describe four patients with Type 1 diabetes mellitus and coeliac disease who developed lymphoma. CASE REPORTS: Two patients were male and two female. In three patients, coeliac disease and lymphoma were diagnosed simultaneously. Enteropathy-associated T cell lymphoma occurred in two patients, Hodgkin's disease in one, and B cell lymphoma in one. Response to treatment was in general poor, and three patients died soon after the diagnosis of lymphoma was made. CONCLUSION: As the relative risk of lymphoma is reduced by a gluten-free diet, a high index of suspicion for coeliac disease should exist in all Type 1 diabetic patients with unexplained constitutional or gastrointestinal symptoms.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshCeliac Disease/*complications/*diagnosisen_GB
dc.subject.meshDiabetes Mellitus, Type 1/*complications/*diagnosisen_GB
dc.subject.meshDiabetic Ketoacidosis/diagnosisen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHodgkin Disease/complications/diagnosisen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLymphoma/*complications/*diagnosisen_GB
dc.subject.meshLymphoma, B-Cell/complications/diagnosisen_GB
dc.subject.meshLymphoma, T-Cell/complications/diagnosisen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.titleType 1 diabetes mellitus, coeliac disease, and lymphoma: a report of four cases.en_GB
dc.contributor.departmentDepartment of Medicine, Cork University Hospital, Wilton, Ireland., terryoconnor@tinet.ieen_GB
dc.identifier.journalDiabetic medicine : a journal of the British Diabetic Associationen_GB
dc.description.provinceMunster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.