The effects of ropivacaine hydrochloride on coagulation and fibrinolysis. An assessment using thromboelastography.

Hdl Handle:
http://hdl.handle.net/10147/209144
Title:
The effects of ropivacaine hydrochloride on coagulation and fibrinolysis. An assessment using thromboelastography.
Authors:
Porter, J M; McGinley, J; O'Hare, B; Shorten, G D
Affiliation:
Department of Anaesthesia & Intensive Care Medicine, Cork University Hospital,, University College Cork, Wilton, Cork, Republic of Ireland.
Citation:
Anaesthesia. 1999 Sep;54(9):902-6.
Journal:
Anaesthesia
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209144
PubMed ID:
10460568
Abstract:
Amide local anaesthetics impair coagulation by inhibition of platelet function and enhanced fibrinolysis. The potential therefore exists that the presence of amide local anaesthetics in the epidural space could contribute to the therapeutic failure of an epidural autologous blood patch. Ropivacaine is an aminoamide local anaesthetic increasingly used for epidural analgesia and anaesthesia, particularly in obstetric practice. This study was undertaken to investigate whether concentrations of ropivacaine in blood, which could occur clinically in the epidural space, alter coagulation or fibrinolysis. Thromboelastography was used to assess clotting and fibrinolysis of blood to which ropivacaine had been added. Although modest alterations in maximum amplitude, coagulation time and alpha angle were observed, the effect of ropivacaine on clotting and fibrinolysis was not clinically significant. We conclude that it is unlikely that the presence of ropivacaine in the epidural space would reduce the efficacy of an early or prophylactic epidural blood patch.
Language:
eng
MeSH:
Adult; Amides/blood/*pharmacology; Anesthetics, Local/blood/*pharmacology; Blood Coagulation/*drug effects; Dose-Response Relationship, Drug; Female; Fibrinolysis/*drug effects; Humans; Male; Middle Aged; Partial Thromboplastin Time; Prothrombin Time; Thrombelastography
ISSN:
0003-2409 (Print); 0003-2409 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorPorter, J Men_GB
dc.contributor.authorMcGinley, Jen_GB
dc.contributor.authorO'Hare, Ben_GB
dc.contributor.authorShorten, G Den_GB
dc.date.accessioned2012-02-03T15:13:25Z-
dc.date.available2012-02-03T15:13:25Z-
dc.date.issued2012-02-03T15:13:25Z-
dc.identifier.citationAnaesthesia. 1999 Sep;54(9):902-6.en_GB
dc.identifier.issn0003-2409 (Print)en_GB
dc.identifier.issn0003-2409 (Linking)en_GB
dc.identifier.pmid10460568en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209144-
dc.description.abstractAmide local anaesthetics impair coagulation by inhibition of platelet function and enhanced fibrinolysis. The potential therefore exists that the presence of amide local anaesthetics in the epidural space could contribute to the therapeutic failure of an epidural autologous blood patch. Ropivacaine is an aminoamide local anaesthetic increasingly used for epidural analgesia and anaesthesia, particularly in obstetric practice. This study was undertaken to investigate whether concentrations of ropivacaine in blood, which could occur clinically in the epidural space, alter coagulation or fibrinolysis. Thromboelastography was used to assess clotting and fibrinolysis of blood to which ropivacaine had been added. Although modest alterations in maximum amplitude, coagulation time and alpha angle were observed, the effect of ropivacaine on clotting and fibrinolysis was not clinically significant. We conclude that it is unlikely that the presence of ropivacaine in the epidural space would reduce the efficacy of an early or prophylactic epidural blood patch.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAmides/blood/*pharmacologyen_GB
dc.subject.meshAnesthetics, Local/blood/*pharmacologyen_GB
dc.subject.meshBlood Coagulation/*drug effectsen_GB
dc.subject.meshDose-Response Relationship, Drugen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFibrinolysis/*drug effectsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPartial Thromboplastin Timeen_GB
dc.subject.meshProthrombin Timeen_GB
dc.subject.meshThrombelastographyen_GB
dc.titleThe effects of ropivacaine hydrochloride on coagulation and fibrinolysis. An assessment using thromboelastography.en_GB
dc.contributor.departmentDepartment of Anaesthesia & Intensive Care Medicine, Cork University Hospital,, University College Cork, Wilton, Cork, Republic of Ireland.en_GB
dc.identifier.journalAnaesthesiaen_GB
dc.description.provinceMunster-

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