Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.

Hdl Handle:
http://hdl.handle.net/10147/209133
Title:
Cisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.
Authors:
Lydon, A; Murray, C; McGinley, J; Plant, R; Duggan, F; Shorten, G
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College Cork, Ireland.
Citation:
Can J Anaesth. 1999 Dec;46(12):1181-4.
Journal:
Canadian journal of anaesthesia = Journal canadien d'anesthesie
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209133
DOI:
10.1007/BF03015530
PubMed ID:
10608215
Abstract:
PURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical patients. METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride p.o. or placebo preoperatively to 64 ASA 1-2 ambulatory surgical patients. Following induction of anesthesia we measured volume and pH of residual gastric contents, using blind aspiration through an orogastric tube. Parametric data were analysed using unpaired, one tail Students' t test. Non-parametric data were analysed using Fishers Exact test and Chi square analysis. Statistical significance was accepted at the probability level of < 0.05. RESULTS: Residual gastric volumes were similar in the two groups (19.5 +/- 23.8, 23.9 +/- 24.4 ml), in the cisapride and placebo groups respectively, P=0.24). Data shown are mean (+/- SD). The proportions of patients with a residual gastric volume exceeding 0.4 ml x kg(-1) were similar in the two groups (4 of 28, and 8 of 23 patients in the cisapride and placebo groups respectively, P=0.09). The pH of the residual gastric contents were similar in the cisapride and placebo groups (1.6 +/- 0.5, 1.4 +/- 0.5, respectively, P=0.26). The proportions of patients with pH < 2.5 was also similar in the cisapride and placebo groups (21 of 25, and 20 of 21 patients respectively, P=0.2). CONCLUSIONS: Preoperative administration of 20 mg cisapride p.o. to patients scheduled for outpatient surgery does not alter either the volume or the pH of gastric contents. Its use in this setting is of no apparent clinical benefit.
Language:
eng
MeSH:
Adult; *Ambulatory Surgical Procedures; *Cisapride; Double-Blind Method; Female; Gastrointestinal Contents/chemistry; Hemodynamics/drug effects; Humans; Hydrogen-Ion Concentration; Male; *Preoperative Care; Prospective Studies; Stomach/anatomy & histology/*drug effects/metabolism
ISSN:
0832-610X (Print); 0832-610X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorLydon, Aen_GB
dc.contributor.authorMurray, Cen_GB
dc.contributor.authorMcGinley, Jen_GB
dc.contributor.authorPlant, Ren_GB
dc.contributor.authorDuggan, Fen_GB
dc.contributor.authorShorten, Gen_GB
dc.date.accessioned2012-02-03T15:13:08Z-
dc.date.available2012-02-03T15:13:08Z-
dc.date.issued2012-02-03T15:13:08Z-
dc.identifier.citationCan J Anaesth. 1999 Dec;46(12):1181-4.en_GB
dc.identifier.issn0832-610X (Print)en_GB
dc.identifier.issn0832-610X (Linking)en_GB
dc.identifier.pmid10608215en_GB
dc.identifier.doi10.1007/BF03015530en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209133-
dc.description.abstractPURPOSE: To evaluate the efficacy of 20 mg cisapride p.o. in reducing residual gastric volume and pH in adult ambulatory surgical patients. METHODS: Using a prospective randomised double-blind controlled design, we administered either 20 mg cisapride p.o. or placebo preoperatively to 64 ASA 1-2 ambulatory surgical patients. Following induction of anesthesia we measured volume and pH of residual gastric contents, using blind aspiration through an orogastric tube. Parametric data were analysed using unpaired, one tail Students' t test. Non-parametric data were analysed using Fishers Exact test and Chi square analysis. Statistical significance was accepted at the probability level of < 0.05. RESULTS: Residual gastric volumes were similar in the two groups (19.5 +/- 23.8, 23.9 +/- 24.4 ml), in the cisapride and placebo groups respectively, P=0.24). Data shown are mean (+/- SD). The proportions of patients with a residual gastric volume exceeding 0.4 ml x kg(-1) were similar in the two groups (4 of 28, and 8 of 23 patients in the cisapride and placebo groups respectively, P=0.09). The pH of the residual gastric contents were similar in the cisapride and placebo groups (1.6 +/- 0.5, 1.4 +/- 0.5, respectively, P=0.26). The proportions of patients with pH < 2.5 was also similar in the cisapride and placebo groups (21 of 25, and 20 of 21 patients respectively, P=0.2). CONCLUSIONS: Preoperative administration of 20 mg cisapride p.o. to patients scheduled for outpatient surgery does not alter either the volume or the pH of gastric contents. Its use in this setting is of no apparent clinical benefit.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.mesh*Ambulatory Surgical Proceduresen_GB
dc.subject.mesh*Cisaprideen_GB
dc.subject.meshDouble-Blind Methoden_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGastrointestinal Contents/chemistryen_GB
dc.subject.meshHemodynamics/drug effectsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHydrogen-Ion Concentrationen_GB
dc.subject.meshMaleen_GB
dc.subject.mesh*Preoperative Careen_GB
dc.subject.meshProspective Studiesen_GB
dc.subject.meshStomach/anatomy & histology/*drug effects/metabolismen_GB
dc.titleCisapride does not alter gastric volume or pH in patients undergoing ambulatory surgery.en_GB
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College Cork, Ireland.en_GB
dc.identifier.journalCanadian journal of anaesthesia = Journal canadien d'anesthesieen_GB
dc.description.provinceMunster-

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