Nutrient tasting and signaling mechanisms in the gut V. Mechanisms of immunologic sensation of intestinal contents.

Hdl Handle:
http://hdl.handle.net/10147/209129
Title:
Nutrient tasting and signaling mechanisms in the gut V. Mechanisms of immunologic sensation of intestinal contents.
Authors:
Shanahan, F
Affiliation:
Department of Medicine, National University of Ireland, University College Cork, and Cork University Hospital, Ireland. Fshanahan@ucc.ie
Citation:
Am J Physiol Gastrointest Liver Physiol. 2000 Feb;278(2):G191-6.
Journal:
American journal of physiology. Gastrointestinal and liver physiology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209129
PubMed ID:
10666042
Abstract:
Immune perception of intestinal contents reflects a functional dualism with systemic hyporesponsiveness to dietary antigens and resident microflora (oral tolerance) and active immune responses to mucosal pathogens. This facilitates optimal absorption of dietary nutrients while conserving immunologic resources for episodic pathogenic challenge. Discrimination between dangerous and harmless antigens within the enteric lumen requires continual sampling of the microenvironment by multiple potential pathways, innate and adaptive recognition mechanisms, bidirectional lymphoepithelial signaling, and rigorous control of effector responses. Errors in these processes disrupt mucosal homeostasis and are associated with food hypersensitivity and mucosal inflammation. Mechanisms of mucosal immune perception and handling of dietary proteins and other antigens have several practical and theoretical implications including vaccine design, therapy of systemic autoimmunity, and alteration of enteric flora with probiotics.
Language:
eng
MeSH:
Animals; Antigens/*immunology; *Food; Humans; Intestines/anatomy & histology/*immunology; Lymphoid Tissue/anatomy & histology/immunology; Signal Transduction
ISSN:
0193-1857 (Print); 0193-1857 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorShanahan, Fen_GB
dc.date.accessioned2012-02-03T15:13:02Z-
dc.date.available2012-02-03T15:13:02Z-
dc.date.issued2012-02-03T15:13:02Z-
dc.identifier.citationAm J Physiol Gastrointest Liver Physiol. 2000 Feb;278(2):G191-6.en_GB
dc.identifier.issn0193-1857 (Print)en_GB
dc.identifier.issn0193-1857 (Linking)en_GB
dc.identifier.pmid10666042en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209129-
dc.description.abstractImmune perception of intestinal contents reflects a functional dualism with systemic hyporesponsiveness to dietary antigens and resident microflora (oral tolerance) and active immune responses to mucosal pathogens. This facilitates optimal absorption of dietary nutrients while conserving immunologic resources for episodic pathogenic challenge. Discrimination between dangerous and harmless antigens within the enteric lumen requires continual sampling of the microenvironment by multiple potential pathways, innate and adaptive recognition mechanisms, bidirectional lymphoepithelial signaling, and rigorous control of effector responses. Errors in these processes disrupt mucosal homeostasis and are associated with food hypersensitivity and mucosal inflammation. Mechanisms of mucosal immune perception and handling of dietary proteins and other antigens have several practical and theoretical implications including vaccine design, therapy of systemic autoimmunity, and alteration of enteric flora with probiotics.en_GB
dc.language.isoengen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshAntigens/*immunologyen_GB
dc.subject.mesh*Fooden_GB
dc.subject.meshHumansen_GB
dc.subject.meshIntestines/anatomy & histology/*immunologyen_GB
dc.subject.meshLymphoid Tissue/anatomy & histology/immunologyen_GB
dc.subject.meshSignal Transductionen_GB
dc.titleNutrient tasting and signaling mechanisms in the gut V. Mechanisms of immunologic sensation of intestinal contents.en_GB
dc.contributor.departmentDepartment of Medicine, National University of Ireland, University College Cork, and Cork University Hospital, Ireland. Fshanahan@ucc.ieen_GB
dc.identifier.journalAmerican journal of physiology. Gastrointestinal and liver physiologyen_GB
dc.description.provinceMunster-

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