Evaluation of standard haemodynamic tests of autonomic function and HbA1c as predictors of delayed gastric emptying in patients with type 1 diabetes mellitus.

Hdl Handle:
http://hdl.handle.net/10147/209124
Title:
Evaluation of standard haemodynamic tests of autonomic function and HbA1c as predictors of delayed gastric emptying in patients with type 1 diabetes mellitus.
Authors:
Lydon, A; Murray, C; Cooke, T; Duggan, P F; O'Halloran, D; Shorten, G D
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College Cork, Cork, Ireland.
Citation:
Eur J Anaesthesiol. 2000 Feb;17(2):99-104.
Journal:
European journal of anaesthesiology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209124
PubMed ID:
10758453
Abstract:
We examined the relation between chronic glycaemic control (using glycosylated haemoglobin), haemodynamic autonomic function and rate of gastric emptying in 16 patients with type 1 diabetes mellitus. Gastric emptying was measured using a paracetamol absorption technique. Parameters of gastric emptying include area under the plasma paracetamol concentration time curve. Patients were classified as diabetic autonomic neuropathy positive or negative using five standardized haemodynamic reflex tests. Area under the plasma paracetamol concentration time curve in the neuropathy positive (10.36 (4.5) mmol.-1. min) and negative (9.84 (3.0) mmol.-1. min) groups were similar (.P.=0.42) using unpaired Student's.t. -tests. Glycosylated haemoglobin concentration and area under the plasma paracetamol concentration time curve (.n.=16) demonstrated a Pearson's correlation co-efficient of 0.24. Neither tests of haemodynamic autonomic function, nor concentration of glycosylated haemoglobin, are predictive of diabetic gastroparesis.
Language:
eng
MeSH:
Absorption; Acetaminophen/blood/diagnostic use; Analgesics, Non-Narcotic/blood/diagnostic use; Area Under Curve; Autonomic Nervous System/*physiopathology; Autonomic Nervous System Diseases/physiopathology; Blood Glucose/analysis; Blood Pressure/physiology; Diabetes Mellitus, Type 1/blood/complications/*physiopathology; Diabetic Neuropathies/physiopathology; Evaluation Studies as Topic; Female; Forecasting; Gastric Emptying/*physiology; Gastroparesis/etiology/physiopathology; Hand Strength/physiology; Heart Rate/physiology; Hemodynamics/*physiology; Hemoglobin A, Glycosylated/*analysis; Humans; Male; Middle Aged; Reproducibility of Results; Statistics as Topic; Valsalva Maneuver/physiology
ISSN:
0265-0215 (Print); 0265-0215 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorLydon, Aen_GB
dc.contributor.authorMurray, Cen_GB
dc.contributor.authorCooke, Ten_GB
dc.contributor.authorDuggan, P Fen_GB
dc.contributor.authorO'Halloran, Den_GB
dc.contributor.authorShorten, G Den_GB
dc.date.accessioned2012-02-03T15:12:54Z-
dc.date.available2012-02-03T15:12:54Z-
dc.date.issued2012-02-03T15:12:54Z-
dc.identifier.citationEur J Anaesthesiol. 2000 Feb;17(2):99-104.en_GB
dc.identifier.issn0265-0215 (Print)en_GB
dc.identifier.issn0265-0215 (Linking)en_GB
dc.identifier.pmid10758453en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209124-
dc.description.abstractWe examined the relation between chronic glycaemic control (using glycosylated haemoglobin), haemodynamic autonomic function and rate of gastric emptying in 16 patients with type 1 diabetes mellitus. Gastric emptying was measured using a paracetamol absorption technique. Parameters of gastric emptying include area under the plasma paracetamol concentration time curve. Patients were classified as diabetic autonomic neuropathy positive or negative using five standardized haemodynamic reflex tests. Area under the plasma paracetamol concentration time curve in the neuropathy positive (10.36 (4.5) mmol.-1. min) and negative (9.84 (3.0) mmol.-1. min) groups were similar (.P.=0.42) using unpaired Student's.t. -tests. Glycosylated haemoglobin concentration and area under the plasma paracetamol concentration time curve (.n.=16) demonstrated a Pearson's correlation co-efficient of 0.24. Neither tests of haemodynamic autonomic function, nor concentration of glycosylated haemoglobin, are predictive of diabetic gastroparesis.en_GB
dc.language.isoengen_GB
dc.subject.meshAbsorptionen_GB
dc.subject.meshAcetaminophen/blood/diagnostic useen_GB
dc.subject.meshAnalgesics, Non-Narcotic/blood/diagnostic useen_GB
dc.subject.meshArea Under Curveen_GB
dc.subject.meshAutonomic Nervous System/*physiopathologyen_GB
dc.subject.meshAutonomic Nervous System Diseases/physiopathologyen_GB
dc.subject.meshBlood Glucose/analysisen_GB
dc.subject.meshBlood Pressure/physiologyen_GB
dc.subject.meshDiabetes Mellitus, Type 1/blood/complications/*physiopathologyen_GB
dc.subject.meshDiabetic Neuropathies/physiopathologyen_GB
dc.subject.meshEvaluation Studies as Topicen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshForecastingen_GB
dc.subject.meshGastric Emptying/*physiologyen_GB
dc.subject.meshGastroparesis/etiology/physiopathologyen_GB
dc.subject.meshHand Strength/physiologyen_GB
dc.subject.meshHeart Rate/physiologyen_GB
dc.subject.meshHemodynamics/*physiologyen_GB
dc.subject.meshHemoglobin A, Glycosylated/*analysisen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshReproducibility of Resultsen_GB
dc.subject.meshStatistics as Topicen_GB
dc.subject.meshValsalva Maneuver/physiologyen_GB
dc.titleEvaluation of standard haemodynamic tests of autonomic function and HbA1c as predictors of delayed gastric emptying in patients with type 1 diabetes mellitus.en_GB
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College Cork, Cork, Ireland.en_GB
dc.identifier.journalEuropean journal of anaesthesiologyen_GB
dc.description.provinceMunster-

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