Does chronic occupational exposure to volatile anesthetic agents influence the rate of neutrophil apoptosis?

Hdl Handle:
http://hdl.handle.net/10147/209123
Title:
Does chronic occupational exposure to volatile anesthetic agents influence the rate of neutrophil apoptosis?
Authors:
Goto, Y; Gallagher, J; Fanning, N; Wang, J; McCusker, S; Redmond, P; Shorten, G
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , University College Cork, Ireland.
Citation:
Can J Anaesth. 2000 Apr;47(4):350-3.
Journal:
Canadian journal of anaesthesia = Journal canadien d'anesthesie
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209123
DOI:
10.1007/BF03020952
PubMed ID:
10764182
Abstract:
PURPOSE: The purpose of this preliminary investigation was to determine whether the rate of neutrophil apoptosis in health care workers is influenced by exposure to volatile anesthetic agents. METHODS: Percentage neutrophil apoptosis (Annexin-V FITC assay) was measured in health care workers (n = 20) and unexposed volunteers (n = 10). For the health care workers, time weighted personal exposure monitoring to N2O, sevoflurane and isoflurane was carried out. RESULTS: The sevoflurane and isoflurane concentrations to which health care workers were exposed were less than recommended levels in all 20 cases. Percent apoptosis was less at 24 (but not at one and 12) hr culture in health care workers [50.5 (9.7)%; P = 0.008] than in unexposed volunteers [57.3 (5.1)%]. CONCLUSION: Inhibition of neutrophil apoptosis at 24 hr culture was demonstrated in health care workers chronically exposed to volatile anesthetic agents. Exposure was well below recommended levels in the both scavenged and unscavenged work areas in which the study was carried out. Further study is required to assess the effect of greater degrees of chronic exposure to volatile anesthetic agents on neutrophil apoptosis.
Language:
eng
MeSH:
Adult; *Anesthesiology; Anesthetics, Inhalation/*adverse effects/analysis; Apoptosis/*drug effects; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Isoflurane/adverse effects/analysis; Male; Methyl Ethers/adverse effects/analysis; Neutrophils/*drug effects; Nitrous Oxide/adverse effects/analysis; Occupational Exposure/*adverse effects/analysis; Time Factors; Ventilation
ISSN:
0832-610X (Print); 0832-610X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorGoto, Yen_GB
dc.contributor.authorGallagher, Jen_GB
dc.contributor.authorFanning, Nen_GB
dc.contributor.authorWang, Jen_GB
dc.contributor.authorMcCusker, Sen_GB
dc.contributor.authorRedmond, Pen_GB
dc.contributor.authorShorten, Gen_GB
dc.date.accessioned2012-02-03T15:12:52Z-
dc.date.available2012-02-03T15:12:52Z-
dc.date.issued2012-02-03T15:12:52Z-
dc.identifier.citationCan J Anaesth. 2000 Apr;47(4):350-3.en_GB
dc.identifier.issn0832-610X (Print)en_GB
dc.identifier.issn0832-610X (Linking)en_GB
dc.identifier.pmid10764182en_GB
dc.identifier.doi10.1007/BF03020952en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209123-
dc.description.abstractPURPOSE: The purpose of this preliminary investigation was to determine whether the rate of neutrophil apoptosis in health care workers is influenced by exposure to volatile anesthetic agents. METHODS: Percentage neutrophil apoptosis (Annexin-V FITC assay) was measured in health care workers (n = 20) and unexposed volunteers (n = 10). For the health care workers, time weighted personal exposure monitoring to N2O, sevoflurane and isoflurane was carried out. RESULTS: The sevoflurane and isoflurane concentrations to which health care workers were exposed were less than recommended levels in all 20 cases. Percent apoptosis was less at 24 (but not at one and 12) hr culture in health care workers [50.5 (9.7)%; P = 0.008] than in unexposed volunteers [57.3 (5.1)%]. CONCLUSION: Inhibition of neutrophil apoptosis at 24 hr culture was demonstrated in health care workers chronically exposed to volatile anesthetic agents. Exposure was well below recommended levels in the both scavenged and unscavenged work areas in which the study was carried out. Further study is required to assess the effect of greater degrees of chronic exposure to volatile anesthetic agents on neutrophil apoptosis.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.mesh*Anesthesiologyen_GB
dc.subject.meshAnesthetics, Inhalation/*adverse effects/analysisen_GB
dc.subject.meshApoptosis/*drug effectsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFluorescein-5-isothiocyanateen_GB
dc.subject.meshFluorescent Dyesen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIsoflurane/adverse effects/analysisen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMethyl Ethers/adverse effects/analysisen_GB
dc.subject.meshNeutrophils/*drug effectsen_GB
dc.subject.meshNitrous Oxide/adverse effects/analysisen_GB
dc.subject.meshOccupational Exposure/*adverse effects/analysisen_GB
dc.subject.meshTime Factorsen_GB
dc.subject.meshVentilationen_GB
dc.titleDoes chronic occupational exposure to volatile anesthetic agents influence the rate of neutrophil apoptosis?en_GB
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , University College Cork, Ireland.en_GB
dc.identifier.journalCanadian journal of anaesthesia = Journal canadien d'anesthesieen_GB
dc.description.provinceMunster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.