Evaluation of the effects of levobupivacaine on clotting and fibrinolysis using thromboelastography.

Hdl Handle:
http://hdl.handle.net/10147/209115
Title:
Evaluation of the effects of levobupivacaine on clotting and fibrinolysis using thromboelastography.
Authors:
Leonard, S A; Walsh, M; Lydon, A; O'Hare, B; Shorten, G D
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College Cork, Ireland.
Citation:
Eur J Anaesthesiol. 2000 Jun;17(6):373-8.
Journal:
European journal of anaesthesiology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209115
PubMed ID:
10928437
Abstract:
Amide local anaesthetics inhibit platelet function. We hypothesized that residual anaesthetic in the epidural space could decrease efficacy of an epidural blood patch in preventing postdural puncture headache. Levobupivacaine has recently been approved for epidural anaesthesia. Its effects on coagulation have not previously been studied. The aim of this study was to determine the effects of levobupivacaine on clotting using thromboelastography. Ten ASA Class I volunteers were studied. Venous blood samples were analysed using a Haemoscope 2000D TEG analyser. Whole blood, a 50% saline control and two levobupivacaine solutions (2.5 mg mL(-1) and 2.5 microg mL(-1) in blood) were compared. The former reproduces that produced in the epidural space by blood (20 mL for an epidural blood patch) and levobupivacaine 0.5% (20 mL). The latter approximates plasma concentrations following epidural injection of levobupivacaine 0.5% (20 mL). P < 0.05 was considered significant. Maximum amplitude (MA), a measure of clot strength, is decreased by levobupivacaine 2.5 mg mL(-1). Levobupivacaine 2.5 mg mL(-1) decreases clot strength and may reduce efficacy of a prophylactic epidural blood patch.
Language:
eng
MeSH:
Adult; Anesthesia, Epidural; Anesthetics, Local/*pharmacology; Blood Coagulation/*drug effects; Blood Patch, Epidural; Bupivacaine/*pharmacology; Female; Fibrinolysis/*drug effects; Humans; Male; Prospective Studies; *Thrombelastography
ISSN:
0265-0215 (Print); 0265-0215 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorLeonard, S Aen_GB
dc.contributor.authorWalsh, Men_GB
dc.contributor.authorLydon, Aen_GB
dc.contributor.authorO'Hare, Ben_GB
dc.contributor.authorShorten, G Den_GB
dc.date.accessioned2012-02-03T15:12:40Z-
dc.date.available2012-02-03T15:12:40Z-
dc.date.issued2012-02-03T15:12:40Z-
dc.identifier.citationEur J Anaesthesiol. 2000 Jun;17(6):373-8.en_GB
dc.identifier.issn0265-0215 (Print)en_GB
dc.identifier.issn0265-0215 (Linking)en_GB
dc.identifier.pmid10928437en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209115-
dc.description.abstractAmide local anaesthetics inhibit platelet function. We hypothesized that residual anaesthetic in the epidural space could decrease efficacy of an epidural blood patch in preventing postdural puncture headache. Levobupivacaine has recently been approved for epidural anaesthesia. Its effects on coagulation have not previously been studied. The aim of this study was to determine the effects of levobupivacaine on clotting using thromboelastography. Ten ASA Class I volunteers were studied. Venous blood samples were analysed using a Haemoscope 2000D TEG analyser. Whole blood, a 50% saline control and two levobupivacaine solutions (2.5 mg mL(-1) and 2.5 microg mL(-1) in blood) were compared. The former reproduces that produced in the epidural space by blood (20 mL for an epidural blood patch) and levobupivacaine 0.5% (20 mL). The latter approximates plasma concentrations following epidural injection of levobupivacaine 0.5% (20 mL). P < 0.05 was considered significant. Maximum amplitude (MA), a measure of clot strength, is decreased by levobupivacaine 2.5 mg mL(-1). Levobupivacaine 2.5 mg mL(-1) decreases clot strength and may reduce efficacy of a prophylactic epidural blood patch.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnesthesia, Epiduralen_GB
dc.subject.meshAnesthetics, Local/*pharmacologyen_GB
dc.subject.meshBlood Coagulation/*drug effectsen_GB
dc.subject.meshBlood Patch, Epiduralen_GB
dc.subject.meshBupivacaine/*pharmacologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFibrinolysis/*drug effectsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshProspective Studiesen_GB
dc.subject.mesh*Thrombelastographyen_GB
dc.titleEvaluation of the effects of levobupivacaine on clotting and fibrinolysis using thromboelastography.en_GB
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College Cork, Ireland.en_GB
dc.identifier.journalEuropean journal of anaesthesiologyen_GB
dc.description.provinceMunster-

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