Immunology. Therapeutic manipulation of gut flora.

Hdl Handle:
http://hdl.handle.net/10147/209113
Title:
Immunology. Therapeutic manipulation of gut flora.
Authors:
Shanahan, F
Affiliation:
Department of Medicine, Cork University Hospital, Cork, Ireland. fshanahan@ucc.ie
Citation:
Science. 2000 Aug 25;289(5483):1311-2.
Journal:
Science (New York, N.Y.)
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209113
PubMed ID:
10979858
Abstract:
In developed countries as many as two individuals in every thousand suffer from inflammatory bowel disease (ulcerative colitis and Crohn's disease). In his Perspective, Shanahan discusses a new therapeutic approach to treating these conditions in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders (Steidler et al.).
Language:
eng
MeSH:
Animals; Genetic Engineering; Humans; Immunity, Mucosal; Inflammatory Bowel Diseases/*immunology/*therapy; Interleukin-10/administration & dosage/*biosynthesis/genetics/immunology; Intestinal Mucosa/immunology/microbiology; Intestines/immunology/*microbiology; Lactococcus lactis/*genetics/immunology/metabolism; Mice; Probiotics/*therapeutic use; Recombinant Proteins/administration & dosage/biosynthesis/immunology; T-Lymphocyte Subsets/immunology
ISSN:
0036-8075 (Print); 0036-8075 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorShanahan, Fen_GB
dc.date.accessioned2012-02-03T15:12:36Z-
dc.date.available2012-02-03T15:12:36Z-
dc.date.issued2012-02-03T15:12:36Z-
dc.identifier.citationScience. 2000 Aug 25;289(5483):1311-2.en_GB
dc.identifier.issn0036-8075 (Print)en_GB
dc.identifier.issn0036-8075 (Linking)en_GB
dc.identifier.pmid10979858en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209113-
dc.description.abstractIn developed countries as many as two individuals in every thousand suffer from inflammatory bowel disease (ulcerative colitis and Crohn's disease). In his Perspective, Shanahan discusses a new therapeutic approach to treating these conditions in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders (Steidler et al.).en_GB
dc.language.isoengen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshGenetic Engineeringen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmunity, Mucosalen_GB
dc.subject.meshInflammatory Bowel Diseases/*immunology/*therapyen_GB
dc.subject.meshInterleukin-10/administration & dosage/*biosynthesis/genetics/immunologyen_GB
dc.subject.meshIntestinal Mucosa/immunology/microbiologyen_GB
dc.subject.meshIntestines/immunology/*microbiologyen_GB
dc.subject.meshLactococcus lactis/*genetics/immunology/metabolismen_GB
dc.subject.meshMiceen_GB
dc.subject.meshProbiotics/*therapeutic useen_GB
dc.subject.meshRecombinant Proteins/administration & dosage/biosynthesis/immunologyen_GB
dc.subject.meshT-Lymphocyte Subsets/immunologyen_GB
dc.titleImmunology. Therapeutic manipulation of gut flora.en_GB
dc.contributor.departmentDepartment of Medicine, Cork University Hospital, Cork, Ireland. fshanahan@ucc.ieen_GB
dc.identifier.journalScience (New York, N.Y.)en_GB
dc.description.provinceMunster-

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