Pregnancy and pregnancy outcome in hepatitis C type 1b.

Hdl Handle:
http://hdl.handle.net/10147/209112
Title:
Pregnancy and pregnancy outcome in hepatitis C type 1b.
Authors:
Jabeen, T; Cannon, B; Hogan, J; Crowley, M; Devereux, C; Fanning, L; Kenny-Walsh, E; Shanahan, F; Whelton, M J
Affiliation:
Departments of Medicine, Pathology, and Statistics, Cork University Hospital, and, University College Cork, Cork, Ireland.
Citation:
QJM. 2000 Sep;93(9):597-601.
Journal:
QJM : monthly journal of the Association of Physicians
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209112
PubMed ID:
10984554
Abstract:
A large cohort of rhesus-negative women in Ireland were inadvertently infected with hepatitis C virus following exposure to contaminated anti-D immunoglobulin in 1977-8. This major iatrogenic episode was discovered in 1994. We studied 36 women who had been infected after their first pregnancy, and compared them to an age- and parity-matched control group of rhesus-positive women. The presence of hepatitis C antibody was confirmed in all 36 by enzyme-linked immunosorbent assay and by recombinant immunoblot assay, while 26 (72%) of the cohort were HCV-RNA-positive (type 1b) on PCR testing. In the 20 years post-infection, all members of the study group had at least one pregnancy, and mean parity was 3.5. They had a total of 100 pregnancies and 85 of these went to term. There were four premature births, one being a twin pregnancy, and 11 spontaneous miscarriages. One miscarriage occurred in the pregnancy following HCV infection. There were two neonatal deaths due to severe congenital abnormalities in the PCR-positive women. Of the children born to HCV-RNA positive mothers, only one (2.3%) tested positive for the virus. Significant portal fibrosis on liver biopsy was confined to HCV-RNA-positive mothers apart from one single exception in the antibody-positive HCV-RNA-negative group. Comparison with the control group showed no increase in spontaneous miscarriage rate, and no significant difference in obstetric complications; birth weights were similar for the two groups.
Language:
eng
MeSH:
Adult; Case-Control Studies; Congenital Abnormalities; Female; Fetal Death; Fibrosis; Hepacivirus/genetics; *Hepatitis C, Chronic; Humans; *Iatrogenic Disease; Infant, Newborn; Infant, Premature; Infectious Disease Transmission, Vertical; Liver/pathology; Parity; Pregnancy; *Pregnancy Complications, Infectious; RNA, Viral/blood; Reverse Transcriptase Polymerase Chain Reaction; Rh Isoimmunization/therapy; Rho(D) Immune Globulin/administration & dosage; Twins
ISSN:
1460-2725 (Print); 1460-2393 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorJabeen, Ten_GB
dc.contributor.authorCannon, Ben_GB
dc.contributor.authorHogan, Jen_GB
dc.contributor.authorCrowley, Men_GB
dc.contributor.authorDevereux, Cen_GB
dc.contributor.authorFanning, Len_GB
dc.contributor.authorKenny-Walsh, Een_GB
dc.contributor.authorShanahan, Fen_GB
dc.contributor.authorWhelton, M Jen_GB
dc.date.accessioned2012-02-03T15:12:35Z-
dc.date.available2012-02-03T15:12:35Z-
dc.date.issued2012-02-03T15:12:35Z-
dc.identifier.citationQJM. 2000 Sep;93(9):597-601.en_GB
dc.identifier.issn1460-2725 (Print)en_GB
dc.identifier.issn1460-2393 (Linking)en_GB
dc.identifier.pmid10984554en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209112-
dc.description.abstractA large cohort of rhesus-negative women in Ireland were inadvertently infected with hepatitis C virus following exposure to contaminated anti-D immunoglobulin in 1977-8. This major iatrogenic episode was discovered in 1994. We studied 36 women who had been infected after their first pregnancy, and compared them to an age- and parity-matched control group of rhesus-positive women. The presence of hepatitis C antibody was confirmed in all 36 by enzyme-linked immunosorbent assay and by recombinant immunoblot assay, while 26 (72%) of the cohort were HCV-RNA-positive (type 1b) on PCR testing. In the 20 years post-infection, all members of the study group had at least one pregnancy, and mean parity was 3.5. They had a total of 100 pregnancies and 85 of these went to term. There were four premature births, one being a twin pregnancy, and 11 spontaneous miscarriages. One miscarriage occurred in the pregnancy following HCV infection. There were two neonatal deaths due to severe congenital abnormalities in the PCR-positive women. Of the children born to HCV-RNA positive mothers, only one (2.3%) tested positive for the virus. Significant portal fibrosis on liver biopsy was confined to HCV-RNA-positive mothers apart from one single exception in the antibody-positive HCV-RNA-negative group. Comparison with the control group showed no increase in spontaneous miscarriage rate, and no significant difference in obstetric complications; birth weights were similar for the two groups.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshCongenital Abnormalitiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFetal Deathen_GB
dc.subject.meshFibrosisen_GB
dc.subject.meshHepacivirus/geneticsen_GB
dc.subject.mesh*Hepatitis C, Chronicen_GB
dc.subject.meshHumansen_GB
dc.subject.mesh*Iatrogenic Diseaseen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshInfant, Prematureen_GB
dc.subject.meshInfectious Disease Transmission, Verticalen_GB
dc.subject.meshLiver/pathologyen_GB
dc.subject.meshParityen_GB
dc.subject.meshPregnancyen_GB
dc.subject.mesh*Pregnancy Complications, Infectiousen_GB
dc.subject.meshRNA, Viral/blooden_GB
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_GB
dc.subject.meshRh Isoimmunization/therapyen_GB
dc.subject.meshRho(D) Immune Globulin/administration & dosageen_GB
dc.subject.meshTwinsen_GB
dc.titlePregnancy and pregnancy outcome in hepatitis C type 1b.en_GB
dc.contributor.departmentDepartments of Medicine, Pathology, and Statistics, Cork University Hospital, and, University College Cork, Cork, Ireland.en_GB
dc.identifier.journalQJM : monthly journal of the Association of Physiciansen_GB
dc.description.provinceMunster-

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