General versus regional anaesthesia for cataract surgery: effects on neutrophil apoptosis and the postoperative pro-inflammatory state.

Hdl Handle:
http://hdl.handle.net/10147/209110
Title:
General versus regional anaesthesia for cataract surgery: effects on neutrophil apoptosis and the postoperative pro-inflammatory state.
Authors:
Goto, Y; Ho, S L; McAdoo, J; Fanning, N F; Wang, J; Redmond, H P; Shorten, G D
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Department of, Ophthalmology, and Department of Surgery, Cork University Hospital, University, College Cork, Ireland.
Citation:
Eur J Anaesthesiol. 2000 Aug;17(8):474-80.
Journal:
European journal of anaesthesiology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209110
PubMed ID:
10998029
Abstract:
At clinically relevant concentrations, volatile anaesthetic agents influence neutrophil function. Our hypothesis was that sevoflurane would inhibit neutrophil apoptosis and consequently influence the postoperative pro-inflammatory state. In order to identify selectively the effect of the anaesthetic agent sevoflurane, we studied patients undergoing minimally stimulating (cataract) surgery randomly allocated to receive either sevoflurane (n = 11) or local anaesthesia (n = 12). Venous blood samples were taken immediately prior to anaesthesia and at 1, 8 and 24 h thereafter. The rate of neutrophil apoptosis, plasma concentration of cytokines and differential white cell count were measured. The rates of neutrophil apoptosis and plasma concentrations of IL-1beta, TNF-alpha and IL-8 at each time point were similar in the two groups. IL-6 concentrations increased significantly and to a similar extent compared to preanaesthetic levels at 8 and 24 h. This study demonstrates that sevoflurane does not influence the rate of neutrophil apoptosis, cytokine concentrations and neutrophil count following cataract surgery.
Language:
eng
MeSH:
Aged; Analysis of Variance; *Anesthesia, Inhalation; *Anesthesia, Local; Anesthetics, Inhalation/*administration & dosage; Anesthetics, Local/*administration & dosage; Apoptosis/*drug effects; Bupivacaine/administration & dosage; *Cataract Extraction; Female; Follow-Up Studies; Humans; Inflammation/immunology; Inflammation Mediators/*blood; Interleukin-1/blood; Interleukin-6/blood; Leukocyte Count; Lidocaine/administration & dosage; Male; Methyl Ethers/administration & dosage; *Nerve Block; Neutrophils/*drug effects; Surgical Procedures, Minimally Invasive; Tumor Necrosis Factor-alpha/analysis
ISSN:
0265-0215 (Print); 0265-0215 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorGoto, Yen_GB
dc.contributor.authorHo, S Len_GB
dc.contributor.authorMcAdoo, Jen_GB
dc.contributor.authorFanning, N Fen_GB
dc.contributor.authorWang, Jen_GB
dc.contributor.authorRedmond, H Pen_GB
dc.contributor.authorShorten, G Den_GB
dc.date.accessioned2012-02-03T15:12:31Z-
dc.date.available2012-02-03T15:12:31Z-
dc.date.issued2012-02-03T15:12:31Z-
dc.identifier.citationEur J Anaesthesiol. 2000 Aug;17(8):474-80.en_GB
dc.identifier.issn0265-0215 (Print)en_GB
dc.identifier.issn0265-0215 (Linking)en_GB
dc.identifier.pmid10998029en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209110-
dc.description.abstractAt clinically relevant concentrations, volatile anaesthetic agents influence neutrophil function. Our hypothesis was that sevoflurane would inhibit neutrophil apoptosis and consequently influence the postoperative pro-inflammatory state. In order to identify selectively the effect of the anaesthetic agent sevoflurane, we studied patients undergoing minimally stimulating (cataract) surgery randomly allocated to receive either sevoflurane (n = 11) or local anaesthesia (n = 12). Venous blood samples were taken immediately prior to anaesthesia and at 1, 8 and 24 h thereafter. The rate of neutrophil apoptosis, plasma concentration of cytokines and differential white cell count were measured. The rates of neutrophil apoptosis and plasma concentrations of IL-1beta, TNF-alpha and IL-8 at each time point were similar in the two groups. IL-6 concentrations increased significantly and to a similar extent compared to preanaesthetic levels at 8 and 24 h. This study demonstrates that sevoflurane does not influence the rate of neutrophil apoptosis, cytokine concentrations and neutrophil count following cataract surgery.en_GB
dc.language.isoengen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAnalysis of Varianceen_GB
dc.subject.mesh*Anesthesia, Inhalationen_GB
dc.subject.mesh*Anesthesia, Localen_GB
dc.subject.meshAnesthetics, Inhalation/*administration & dosageen_GB
dc.subject.meshAnesthetics, Local/*administration & dosageen_GB
dc.subject.meshApoptosis/*drug effectsen_GB
dc.subject.meshBupivacaine/administration & dosageen_GB
dc.subject.mesh*Cataract Extractionen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFollow-Up Studiesen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInflammation/immunologyen_GB
dc.subject.meshInflammation Mediators/*blooden_GB
dc.subject.meshInterleukin-1/blooden_GB
dc.subject.meshInterleukin-6/blooden_GB
dc.subject.meshLeukocyte Counten_GB
dc.subject.meshLidocaine/administration & dosageen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMethyl Ethers/administration & dosageen_GB
dc.subject.mesh*Nerve Blocken_GB
dc.subject.meshNeutrophils/*drug effectsen_GB
dc.subject.meshSurgical Procedures, Minimally Invasiveen_GB
dc.subject.meshTumor Necrosis Factor-alpha/analysisen_GB
dc.titleGeneral versus regional anaesthesia for cataract surgery: effects on neutrophil apoptosis and the postoperative pro-inflammatory state.en_GB
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Department of, Ophthalmology, and Department of Surgery, Cork University Hospital, University, College Cork, Ireland.en_GB
dc.identifier.journalEuropean journal of anaesthesiologyen_GB
dc.description.provinceMunster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.