Biological behaviour and clinical implications of micrometastases.

Hdl Handle:
http://hdl.handle.net/10147/209101
Title:
Biological behaviour and clinical implications of micrometastases.
Authors:
Kell, M R; Winter, D C; O'Sullivan, G C; Shanahan, F; Redmond, H P
Affiliation:
Departments of Academic Surgery and Medicine, National University of Ireland,, Cork University Hospital and Mercy Hospital, Cork, Ireland.
Citation:
Br J Surg. 2000 Dec;87(12):1629-39.
Journal:
The British journal of surgery
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209101
DOI:
10.1046/j.1365-2168.2000.01606.x
PubMed ID:
11122176
Abstract:
BACKGROUND: The most important prognostic determinant in cancer is the identification of disseminated tumour burden (metastases). Micrometastases are microscopic (smaller than 2 mm) deposits of malignant cells that are segregated spatially from the primary tumour and depend on neovascular formation (angiogenesis) to propagate. METHODS: The electronic literature (1966 to present) on micrometastases and their implications in malignant melanoma and epithelial cancers was reviewed. RESULTS: Immunohistochemical techniques combined with serial sectioning offer the best accuracy for detection of nodal micrometastases. Molecular techniques should be reserved for blood samples or bone marrow aspirates. Detection of micrometastases in regional lymph nodes and/or bone marrow confers a poor prognosis in epithelial cancers. The concept of sentinel node biopsy combined with serial sectioning and dedicated screening for micrometastases may improve staging procedures. Strategies against angiogenesis may provide novel therapies to induce and maintain micrometastatic dormancy. CONCLUSION: The concept of micrometastases has resulted in a paradigm shift in the staging of epithelial tumours and our overall understanding of malignant processes.
Language:
eng
MeSH:
Biopsy, Needle/methods; Bone Marrow Neoplasms/diagnosis; Breast Neoplasms/diagnosis; Colorectal Neoplasms/diagnosis; Enzyme-Linked Immunosorbent Assay/methods; Flow Cytometry; Head and Neck Neoplasms/diagnosis; Humans; Immunohistochemistry/methods; Lymphatic Metastasis/diagnosis; Melanoma/diagnosis/secondary; Neoplasm Metastasis/*diagnosis; Neoplastic Cells, Circulating; Neovascularization, Pathologic/physiopathology; Stomach Neoplasms/diagnosis
ISSN:
0007-1323 (Print); 0007-1323 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorKell, M Ren_GB
dc.contributor.authorWinter, D Cen_GB
dc.contributor.authorO'Sullivan, G Cen_GB
dc.contributor.authorShanahan, Fen_GB
dc.contributor.authorRedmond, H Pen_GB
dc.date.accessioned2012-02-03T15:12:18Z-
dc.date.available2012-02-03T15:12:18Z-
dc.date.issued2012-02-03T15:12:18Z-
dc.identifier.citationBr J Surg. 2000 Dec;87(12):1629-39.en_GB
dc.identifier.issn0007-1323 (Print)en_GB
dc.identifier.issn0007-1323 (Linking)en_GB
dc.identifier.pmid11122176en_GB
dc.identifier.doi10.1046/j.1365-2168.2000.01606.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/209101-
dc.description.abstractBACKGROUND: The most important prognostic determinant in cancer is the identification of disseminated tumour burden (metastases). Micrometastases are microscopic (smaller than 2 mm) deposits of malignant cells that are segregated spatially from the primary tumour and depend on neovascular formation (angiogenesis) to propagate. METHODS: The electronic literature (1966 to present) on micrometastases and their implications in malignant melanoma and epithelial cancers was reviewed. RESULTS: Immunohistochemical techniques combined with serial sectioning offer the best accuracy for detection of nodal micrometastases. Molecular techniques should be reserved for blood samples or bone marrow aspirates. Detection of micrometastases in regional lymph nodes and/or bone marrow confers a poor prognosis in epithelial cancers. The concept of sentinel node biopsy combined with serial sectioning and dedicated screening for micrometastases may improve staging procedures. Strategies against angiogenesis may provide novel therapies to induce and maintain micrometastatic dormancy. CONCLUSION: The concept of micrometastases has resulted in a paradigm shift in the staging of epithelial tumours and our overall understanding of malignant processes.en_GB
dc.language.isoengen_GB
dc.subject.meshBiopsy, Needle/methodsen_GB
dc.subject.meshBone Marrow Neoplasms/diagnosisen_GB
dc.subject.meshBreast Neoplasms/diagnosisen_GB
dc.subject.meshColorectal Neoplasms/diagnosisen_GB
dc.subject.meshEnzyme-Linked Immunosorbent Assay/methodsen_GB
dc.subject.meshFlow Cytometryen_GB
dc.subject.meshHead and Neck Neoplasms/diagnosisen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmunohistochemistry/methodsen_GB
dc.subject.meshLymphatic Metastasis/diagnosisen_GB
dc.subject.meshMelanoma/diagnosis/secondaryen_GB
dc.subject.meshNeoplasm Metastasis/*diagnosisen_GB
dc.subject.meshNeoplastic Cells, Circulatingen_GB
dc.subject.meshNeovascularization, Pathologic/physiopathologyen_GB
dc.subject.meshStomach Neoplasms/diagnosisen_GB
dc.titleBiological behaviour and clinical implications of micrometastases.en_GB
dc.contributor.departmentDepartments of Academic Surgery and Medicine, National University of Ireland,, Cork University Hospital and Mercy Hospital, Cork, Ireland.en_GB
dc.identifier.journalThe British journal of surgeryen_GB
dc.description.provinceMunster-

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