The effects of aprotinin on blood product transfusion associated with thoracic aortic surgery requiring deep hypothermic circulatory arrest.

Hdl Handle:
http://hdl.handle.net/10147/209099
Title:
The effects of aprotinin on blood product transfusion associated with thoracic aortic surgery requiring deep hypothermic circulatory arrest.
Authors:
Seigne, P W; Shorten, G D; Johnson, R G; Comunale, M E
Affiliation:
Department of Anesthesiology, Cork University Hospital and University College,, Ireland.
Citation:
J Cardiothorac Vasc Anesth. 2000 Dec;14(6):676-81.
Journal:
Journal of cardiothoracic and vascular anesthesia
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209099
DOI:
10.1053/jcan.2000.18325
PubMed ID:
11139108
Abstract:
OBJECTIVE: To compare the effects of aprotinin on blood product use and postoperative complications in patients undergoing thoracic aortic surgery requiring deep hypothermic circulatory arrest. DESIGN: A retrospective study. SETTING: A university hospital. PARTICIPANTS: Nineteen patients who underwent elective or urgent thoracic aortic surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The total number of units of packed red blood cells, fresh frozen plasma, and platelets was significantly less in the group that received aprotinin (p = 0.01, 0.04, and 0.01). The intraoperative transfusion of packed red blood cells and platelets, collection and retransfusion of cell saver, and postoperative transfusion of fresh frozen plasma were also significantly less in the aprotinin group (p = 0.01, 0.02, 0.01, and 0.05). No patient in either group sustained renal dysfunction or a myocardial infarction. Two patients who had not received aprotinin suffered from chronic postoperative seizures, and one patient who had received aprotinin sustained a perioperative stroke. CONCLUSIONS: Low-dose aprotinin administration significantly decreases blood product transfusion requirements in the setting of thoracic aortic surgery requiring deep hypothermic circulatory arrest, and it does not appear to be associated with renal or myocardial dysfunction.
Language:
eng
MeSH:
Aorta, Thoracic/*surgery; Aprotinin/*therapeutic use; *Blood Transfusion; Erythrocyte Transfusion; Female; *Heart Arrest, Induced; Hemostatics/*therapeutic use; Humans; *Hypothermia, Induced; Male; Middle Aged; Plasma; Platelet Transfusion; Postoperative Complications/epidemiology; Retrospective Studies; *Vascular Surgical Procedures
ISSN:
1053-0770 (Print); 1053-0770 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorSeigne, P Wen_GB
dc.contributor.authorShorten, G Den_GB
dc.contributor.authorJohnson, R Gen_GB
dc.contributor.authorComunale, M Een_GB
dc.date.accessioned2012-02-03T15:12:15Z-
dc.date.available2012-02-03T15:12:15Z-
dc.date.issued2012-02-03T15:12:15Z-
dc.identifier.citationJ Cardiothorac Vasc Anesth. 2000 Dec;14(6):676-81.en_GB
dc.identifier.issn1053-0770 (Print)en_GB
dc.identifier.issn1053-0770 (Linking)en_GB
dc.identifier.pmid11139108en_GB
dc.identifier.doi10.1053/jcan.2000.18325en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209099-
dc.description.abstractOBJECTIVE: To compare the effects of aprotinin on blood product use and postoperative complications in patients undergoing thoracic aortic surgery requiring deep hypothermic circulatory arrest. DESIGN: A retrospective study. SETTING: A university hospital. PARTICIPANTS: Nineteen patients who underwent elective or urgent thoracic aortic surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The total number of units of packed red blood cells, fresh frozen plasma, and platelets was significantly less in the group that received aprotinin (p = 0.01, 0.04, and 0.01). The intraoperative transfusion of packed red blood cells and platelets, collection and retransfusion of cell saver, and postoperative transfusion of fresh frozen plasma were also significantly less in the aprotinin group (p = 0.01, 0.02, 0.01, and 0.05). No patient in either group sustained renal dysfunction or a myocardial infarction. Two patients who had not received aprotinin suffered from chronic postoperative seizures, and one patient who had received aprotinin sustained a perioperative stroke. CONCLUSIONS: Low-dose aprotinin administration significantly decreases blood product transfusion requirements in the setting of thoracic aortic surgery requiring deep hypothermic circulatory arrest, and it does not appear to be associated with renal or myocardial dysfunction.en_GB
dc.language.isoengen_GB
dc.subject.meshAorta, Thoracic/*surgeryen_GB
dc.subject.meshAprotinin/*therapeutic useen_GB
dc.subject.mesh*Blood Transfusionen_GB
dc.subject.meshErythrocyte Transfusionen_GB
dc.subject.meshFemaleen_GB
dc.subject.mesh*Heart Arrest, Induceden_GB
dc.subject.meshHemostatics/*therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.mesh*Hypothermia, Induceden_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPlasmaen_GB
dc.subject.meshPlatelet Transfusionen_GB
dc.subject.meshPostoperative Complications/epidemiologyen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.mesh*Vascular Surgical Proceduresen_GB
dc.titleThe effects of aprotinin on blood product transfusion associated with thoracic aortic surgery requiring deep hypothermic circulatory arrest.en_GB
dc.contributor.departmentDepartment of Anesthesiology, Cork University Hospital and University College,, Ireland.en_GB
dc.identifier.journalJournal of cardiothoracic and vascular anesthesiaen_GB
dc.description.provinceMunster-

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