The effects of ropivacaine hydrochloride on platelet function: an assessment using the platelet function analyser (PFA-100).

Hdl Handle:
http://hdl.handle.net/10147/209097
Title:
The effects of ropivacaine hydrochloride on platelet function: an assessment using the platelet function analyser (PFA-100).
Authors:
Porter, J; Crowe, B; Cahill, M; Shorten, G
Affiliation:
Department of Anaesthesia & Intensive Care Medicine, Cork University Hospital and, University College Cork, Ireland.
Citation:
Anaesthesia. 2001 Jan;56(1):15-8.
Journal:
Anaesthesia
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209097
PubMed ID:
11167430
Abstract:
Amide local anaesthetics impair blood clotting in a concentration-dependent manner by inhibition of platelet function and enhanced fibrinolysis. We hypothesised that the presence of ropivacaine in the epidural space could decrease the efficacy of an epidural blood patch, as this technique requires that the injected blood can clot in order to be effective. Ropivacaine is an aminoamide local anaesthetic used increasingly for epidural analgesia during labour. The concentration of local anaesthetic in blood achieved in the epidural space during the performance of an epidural blood patch is likely to be the greatest which occurs (intentionally) in any clinical setting. This study was undertaken to investigate whether concentrations of ropivacaine in blood, which could occur: (i) clinically in the epidural space and (ii) in plasma during an epidural infusion of ropivacaine, alter platelet function. A platelet function analyser (Dade PFA-100, Miami) was employed to assess the effects of ropivacaine-treated blood on platelet function. The greater concentrations of ropivacaine studied (3.75 and 1.88 mg x ml(-1)), which correspond to those which could occur in the epidural space, produced significant inhibition of platelet aggregation. We conclude that the presence of ropivacaine in the epidural space may decrease the efficacy of an early or prophylactic epidural blood patch.
Language:
eng
MeSH:
Adult; Amides/*pharmacology; Anesthesia, Epidural/methods; Anesthetics, Local/*pharmacology; Blood Patch, Epidural; Dose-Response Relationship, Drug; Female; Humans; Male; Platelet Aggregation/*drug effects; Platelet Function Tests/instrumentation; Treatment Outcome
ISSN:
0003-2409 (Print); 0003-2409 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorPorter, Jen_GB
dc.contributor.authorCrowe, Ben_GB
dc.contributor.authorCahill, Men_GB
dc.contributor.authorShorten, Gen_GB
dc.date.accessioned2012-02-03T15:12:11Z-
dc.date.available2012-02-03T15:12:11Z-
dc.date.issued2012-02-03T15:12:11Z-
dc.identifier.citationAnaesthesia. 2001 Jan;56(1):15-8.en_GB
dc.identifier.issn0003-2409 (Print)en_GB
dc.identifier.issn0003-2409 (Linking)en_GB
dc.identifier.pmid11167430en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209097-
dc.description.abstractAmide local anaesthetics impair blood clotting in a concentration-dependent manner by inhibition of platelet function and enhanced fibrinolysis. We hypothesised that the presence of ropivacaine in the epidural space could decrease the efficacy of an epidural blood patch, as this technique requires that the injected blood can clot in order to be effective. Ropivacaine is an aminoamide local anaesthetic used increasingly for epidural analgesia during labour. The concentration of local anaesthetic in blood achieved in the epidural space during the performance of an epidural blood patch is likely to be the greatest which occurs (intentionally) in any clinical setting. This study was undertaken to investigate whether concentrations of ropivacaine in blood, which could occur: (i) clinically in the epidural space and (ii) in plasma during an epidural infusion of ropivacaine, alter platelet function. A platelet function analyser (Dade PFA-100, Miami) was employed to assess the effects of ropivacaine-treated blood on platelet function. The greater concentrations of ropivacaine studied (3.75 and 1.88 mg x ml(-1)), which correspond to those which could occur in the epidural space, produced significant inhibition of platelet aggregation. We conclude that the presence of ropivacaine in the epidural space may decrease the efficacy of an early or prophylactic epidural blood patch.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAmides/*pharmacologyen_GB
dc.subject.meshAnesthesia, Epidural/methodsen_GB
dc.subject.meshAnesthetics, Local/*pharmacologyen_GB
dc.subject.meshBlood Patch, Epiduralen_GB
dc.subject.meshDose-Response Relationship, Drugen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshPlatelet Aggregation/*drug effectsen_GB
dc.subject.meshPlatelet Function Tests/instrumentationen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleThe effects of ropivacaine hydrochloride on platelet function: an assessment using the platelet function analyser (PFA-100).en_GB
dc.contributor.departmentDepartment of Anaesthesia & Intensive Care Medicine, Cork University Hospital and, University College Cork, Ireland.en_GB
dc.identifier.journalAnaesthesiaen_GB
dc.description.provinceMunster-

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