The effects of fenoldopam on coronary conduit blood flow after coronary artery bypass graft surgery.

Hdl Handle:
http://hdl.handle.net/10147/209089
Title:
The effects of fenoldopam on coronary conduit blood flow after coronary artery bypass graft surgery.
Authors:
Halpenny, M; Lakshmi, S; O'Donnell, A; O'Callaghan-Enright, S; O'Connell, D; Shorten, G
Affiliation:
Department of Anesthesia, Cork University Hospital, Wilton, Ireland.
Citation:
J Cardiothorac Vasc Anesth. 2001 Feb;15(1):72-6.
Journal:
Journal of cardiothoracic and vascular anesthesia
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209089
DOI:
10.1053/jcan.2001.20374
PubMed ID:
11254844
Abstract:
OBJECTIVE: To quantify the effects of fenoldopam, 0.1 microg/kg/min, on left internal mammary artery (LIMA) and saphenous vein blood flow after coronary anastomosis. DESIGN: Prospective, randomized, double-blind, placebo-controlled trial. SETTING: University teaching hospital, single institution. PARTICIPANTS: Thirty-one American Society of Anesthesiologists III patients undergoing elective coronary revascularization. INTERVENTIONS: A perivascular ultrasonic flow probe (Linton Instrumentation, Norfolk, UK) was placed around the LIMA and saphenous vein graft after coronary anastomosis. MEASUREMENTS AND MAIN RESULTS: Immediately before and at 5-minute intervals for 15 minutes after starting the infusion, blood flow was measured in the LIMA and one saphenous vein graft using a transit time ultrasonic flow probe. Heart rate, blood pressure, and central venous pressure were documented at these time points. Administration of fenoldopam, 0.1 microg/kg/min, did not alter heart rate or blood pressure. A small, nonsignificant increase in LIMA blood flow occurred during the 15-minute study period (30 +/- 12 to 35 +/- 10 mL/min) in patients who received fenoldopam. No significant changes occurred in the placebo group. CONCLUSIONS: The findings indicate that fenoldopam, 0.1 microg/kg/min, did not influence coronary conduit blood flow to a clinically significant extent. The small increase in LIMA blood flow may be of greater importance in high-risk patients or in the prevention of coronary arterial spasm.
Language:
eng
MeSH:
Aged; Anesthesia; Blood Pressure/drug effects; *Coronary Artery Bypass; Coronary Circulation/*drug effects; Double-Blind Method; Female; Fenoldopam/*pharmacology; Heart Rate/drug effects; Humans; Male; Middle Aged; Myocardial Contraction; Saphenous Vein/transplantation; Vasodilator Agents/*pharmacology
ISSN:
1053-0770 (Print); 1053-0770 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorHalpenny, Men_GB
dc.contributor.authorLakshmi, Sen_GB
dc.contributor.authorO'Donnell, Aen_GB
dc.contributor.authorO'Callaghan-Enright, Sen_GB
dc.contributor.authorO'Connell, Den_GB
dc.contributor.authorShorten, Gen_GB
dc.date.accessioned2012-02-03T15:11:59Z-
dc.date.available2012-02-03T15:11:59Z-
dc.date.issued2012-02-03T15:11:59Z-
dc.identifier.citationJ Cardiothorac Vasc Anesth. 2001 Feb;15(1):72-6.en_GB
dc.identifier.issn1053-0770 (Print)en_GB
dc.identifier.issn1053-0770 (Linking)en_GB
dc.identifier.pmid11254844en_GB
dc.identifier.doi10.1053/jcan.2001.20374en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209089-
dc.description.abstractOBJECTIVE: To quantify the effects of fenoldopam, 0.1 microg/kg/min, on left internal mammary artery (LIMA) and saphenous vein blood flow after coronary anastomosis. DESIGN: Prospective, randomized, double-blind, placebo-controlled trial. SETTING: University teaching hospital, single institution. PARTICIPANTS: Thirty-one American Society of Anesthesiologists III patients undergoing elective coronary revascularization. INTERVENTIONS: A perivascular ultrasonic flow probe (Linton Instrumentation, Norfolk, UK) was placed around the LIMA and saphenous vein graft after coronary anastomosis. MEASUREMENTS AND MAIN RESULTS: Immediately before and at 5-minute intervals for 15 minutes after starting the infusion, blood flow was measured in the LIMA and one saphenous vein graft using a transit time ultrasonic flow probe. Heart rate, blood pressure, and central venous pressure were documented at these time points. Administration of fenoldopam, 0.1 microg/kg/min, did not alter heart rate or blood pressure. A small, nonsignificant increase in LIMA blood flow occurred during the 15-minute study period (30 +/- 12 to 35 +/- 10 mL/min) in patients who received fenoldopam. No significant changes occurred in the placebo group. CONCLUSIONS: The findings indicate that fenoldopam, 0.1 microg/kg/min, did not influence coronary conduit blood flow to a clinically significant extent. The small increase in LIMA blood flow may be of greater importance in high-risk patients or in the prevention of coronary arterial spasm.en_GB
dc.language.isoengen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAnesthesiaen_GB
dc.subject.meshBlood Pressure/drug effectsen_GB
dc.subject.mesh*Coronary Artery Bypassen_GB
dc.subject.meshCoronary Circulation/*drug effectsen_GB
dc.subject.meshDouble-Blind Methoden_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFenoldopam/*pharmacologyen_GB
dc.subject.meshHeart Rate/drug effectsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMyocardial Contractionen_GB
dc.subject.meshSaphenous Vein/transplantationen_GB
dc.subject.meshVasodilator Agents/*pharmacologyen_GB
dc.titleThe effects of fenoldopam on coronary conduit blood flow after coronary artery bypass graft surgery.en_GB
dc.contributor.departmentDepartment of Anesthesia, Cork University Hospital, Wilton, Ireland.en_GB
dc.identifier.journalJournal of cardiothoracic and vascular anesthesiaen_GB
dc.description.provinceMunster-

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