The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation.

Hdl Handle:
http://hdl.handle.net/10147/209071
Title:
The effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation.
Authors:
Swanton, B J; Iohom, G; Wang, J H; Redmond, H P; Shorten, G D
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , Cork, Ireland.
Citation:
Eur J Anaesthesiol. 2001 Aug;18(8):524-9.
Journal:
European journal of anaesthesiology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209071
PubMed ID:
11473559
Abstract:
BACKGROUND AND OBJECTIVE: Respiratory burst is an essential component of the neutrophil's biocidal function. In vitro, sodium thiopental, isoflurane and lidocaine each inhibit neutrophil respiratory burst. The objectives of this study were (a) to determine the effect of a standard clinical induction/tracheal intubation sequence on neutrophil respiratory burst and (b) to determine the effect of intravenous lidocaine administration during induction of anaesthesia on neutrophil respiratory burst. METHODS: Twenty ASA I and II patients, aged 18-60 years, undergoing elective surgery were studied. After induction of anaesthesia [fentanyl (2 microg kg-1), thiopental (4-6 mg kg-1), isoflurane (end-tidal concentration 0.5-1.5%) in nitrous oxide (66%) and oxygen], patients randomly received either lidocaine 1.5 mg kg-1 (group L) or 0.9% saline (group S) prior to tracheal intubation. Neutrophil respiratory burst was measured immediately prior to induction of anaesthesia, immediately before and 1 and 5 min after lidocaine/saline. RESULTS: Neutrophil respiratory burst decreased significantly after induction of anaesthesia in both groups [87.4 +/- 8.2% (group L) and 88.5 +/- 13.4% (group S) of preinduction level (P < 0.01 both groups)]. After intravenous lidocaine (but not saline) administration, neutrophil respiratory burst returned towards preinduction levels, both before (97.1 +/- 23.6%) and after (94.4 +/- 16.6%) tracheal intubation. CONCLUSION: Induction of anaesthesia and tracheal intubation using thiopentone and isoflurane, inhibit neutrophil respiratory burst. This effect may be diminished by the administration of lidocaine.
Language:
eng
MeSH:
Adolescent; Adult; Anesthesia, General/*adverse effects; Anesthetics, Local/*pharmacology; Blood Pressure/drug effects; Female; Fentanyl/adverse effects; Humans; Intubation, Intratracheal; Isoflurane/adverse effects; Lidocaine/*pharmacology; Male; Middle Aged; Neutrophils/*drug effects/metabolism; Prospective Studies; Respiratory Burst/*drug effects; Thiopental/adverse effects
ISSN:
0265-0215 (Print); 0265-0215 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorSwanton, B Jen_GB
dc.contributor.authorIohom, Gen_GB
dc.contributor.authorWang, J Hen_GB
dc.contributor.authorRedmond, H Pen_GB
dc.contributor.authorShorten, G Den_GB
dc.date.accessioned2012-02-03T15:11:29Z-
dc.date.available2012-02-03T15:11:29Z-
dc.date.issued2012-02-03T15:11:29Z-
dc.identifier.citationEur J Anaesthesiol. 2001 Aug;18(8):524-9.en_GB
dc.identifier.issn0265-0215 (Print)en_GB
dc.identifier.issn0265-0215 (Linking)en_GB
dc.identifier.pmid11473559en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209071-
dc.description.abstractBACKGROUND AND OBJECTIVE: Respiratory burst is an essential component of the neutrophil's biocidal function. In vitro, sodium thiopental, isoflurane and lidocaine each inhibit neutrophil respiratory burst. The objectives of this study were (a) to determine the effect of a standard clinical induction/tracheal intubation sequence on neutrophil respiratory burst and (b) to determine the effect of intravenous lidocaine administration during induction of anaesthesia on neutrophil respiratory burst. METHODS: Twenty ASA I and II patients, aged 18-60 years, undergoing elective surgery were studied. After induction of anaesthesia [fentanyl (2 microg kg-1), thiopental (4-6 mg kg-1), isoflurane (end-tidal concentration 0.5-1.5%) in nitrous oxide (66%) and oxygen], patients randomly received either lidocaine 1.5 mg kg-1 (group L) or 0.9% saline (group S) prior to tracheal intubation. Neutrophil respiratory burst was measured immediately prior to induction of anaesthesia, immediately before and 1 and 5 min after lidocaine/saline. RESULTS: Neutrophil respiratory burst decreased significantly after induction of anaesthesia in both groups [87.4 +/- 8.2% (group L) and 88.5 +/- 13.4% (group S) of preinduction level (P < 0.01 both groups)]. After intravenous lidocaine (but not saline) administration, neutrophil respiratory burst returned towards preinduction levels, both before (97.1 +/- 23.6%) and after (94.4 +/- 16.6%) tracheal intubation. CONCLUSION: Induction of anaesthesia and tracheal intubation using thiopentone and isoflurane, inhibit neutrophil respiratory burst. This effect may be diminished by the administration of lidocaine.en_GB
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnesthesia, General/*adverse effectsen_GB
dc.subject.meshAnesthetics, Local/*pharmacologyen_GB
dc.subject.meshBlood Pressure/drug effectsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFentanyl/adverse effectsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIntubation, Intratrachealen_GB
dc.subject.meshIsoflurane/adverse effectsen_GB
dc.subject.meshLidocaine/*pharmacologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshNeutrophils/*drug effects/metabolismen_GB
dc.subject.meshProspective Studiesen_GB
dc.subject.meshRespiratory Burst/*drug effectsen_GB
dc.subject.meshThiopental/adverse effectsen_GB
dc.titleThe effect of lidocaine on neutrophil respiratory burst during induction of general anaesthesia and tracheal intubation.en_GB
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , Cork, Ireland.en_GB
dc.identifier.journalEuropean journal of anaesthesiologyen_GB
dc.description.provinceMunster-
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