Does prior administration of enoxaparin influence the effects of levobupivacaine on blood clotting? Assessment using the Thrombelastograph.

Hdl Handle:
http://hdl.handle.net/10147/209066
Title:
Does prior administration of enoxaparin influence the effects of levobupivacaine on blood clotting? Assessment using the Thrombelastograph.
Authors:
Leonard, S A; Lydon, A; Walsh, M; Fleming, C; Boylan, J; Shorten, G D
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College, Ireland.
Citation:
Br J Anaesth. 2001 Jun;86(6):808-13.
Journal:
British journal of anaesthesia
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209066
PubMed ID:
11573588
Abstract:
The low molecular weight heparin, enoxaparin (by inhibition of factors Xa and IIa) and amide local anaesthetics (by altering platelet function) exert anti-clotting effects. Although these agents are often used in combination during the perioperative period, their potential interactive effect on clotting has not been defined. Blood from 10 ASA I-II patients who received enoxaparin 0.5 mg kg(-1) s.c. was studied using a Thrombelastograph (TEG) either alone or in combination with levobupivacaine (2.5 mg ml(-1) or 2.5 microg ml(-1)) or saline (50% dilution). In blood from patients who had received enoxaparin 0.5 mg kg(-1) s.c. 12 h previously, levobupivacaine 2.5 mg ml(-1) (but not 2.5 microg ml(-1)) produced significant changes in TEG clotting parameters (mean (SD) 15.7 (4.8) mm, 29.6 (25.6) mm, 34.4 (14.6) mm, 34.3 (12.2) degrees compared with control values of 6.1 (1.3) mm, 2.5 (0.5) mm, 63.5 (6.4) mm and 74.1 (2.9) degrees for r, K, MA, and alpha angle respectively).
Language:
eng
MeSH:
Adult; Anesthetics, Local/*pharmacology; Anticoagulants/*therapeutic use; Blood Coagulation/*drug effects; Bupivacaine/*pharmacology; Dose-Response Relationship, Drug; Enoxaparin/*therapeutic use; Factor Xa/analysis; Female; Humans; Male; Middle Aged; Orthopedic Procedures; *Thrombelastography/instrumentation
ISSN:
0007-0912 (Print); 0007-0912 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorLeonard, S Aen_GB
dc.contributor.authorLydon, Aen_GB
dc.contributor.authorWalsh, Men_GB
dc.contributor.authorFleming, Cen_GB
dc.contributor.authorBoylan, Jen_GB
dc.contributor.authorShorten, G Den_GB
dc.date.accessioned2012-02-03T15:11:21Z-
dc.date.available2012-02-03T15:11:21Z-
dc.date.issued2012-02-03T15:11:21Z-
dc.identifier.citationBr J Anaesth. 2001 Jun;86(6):808-13.en_GB
dc.identifier.issn0007-0912 (Print)en_GB
dc.identifier.issn0007-0912 (Linking)en_GB
dc.identifier.pmid11573588en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209066-
dc.description.abstractThe low molecular weight heparin, enoxaparin (by inhibition of factors Xa and IIa) and amide local anaesthetics (by altering platelet function) exert anti-clotting effects. Although these agents are often used in combination during the perioperative period, their potential interactive effect on clotting has not been defined. Blood from 10 ASA I-II patients who received enoxaparin 0.5 mg kg(-1) s.c. was studied using a Thrombelastograph (TEG) either alone or in combination with levobupivacaine (2.5 mg ml(-1) or 2.5 microg ml(-1)) or saline (50% dilution). In blood from patients who had received enoxaparin 0.5 mg kg(-1) s.c. 12 h previously, levobupivacaine 2.5 mg ml(-1) (but not 2.5 microg ml(-1)) produced significant changes in TEG clotting parameters (mean (SD) 15.7 (4.8) mm, 29.6 (25.6) mm, 34.4 (14.6) mm, 34.3 (12.2) degrees compared with control values of 6.1 (1.3) mm, 2.5 (0.5) mm, 63.5 (6.4) mm and 74.1 (2.9) degrees for r, K, MA, and alpha angle respectively).en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnesthetics, Local/*pharmacologyen_GB
dc.subject.meshAnticoagulants/*therapeutic useen_GB
dc.subject.meshBlood Coagulation/*drug effectsen_GB
dc.subject.meshBupivacaine/*pharmacologyen_GB
dc.subject.meshDose-Response Relationship, Drugen_GB
dc.subject.meshEnoxaparin/*therapeutic useen_GB
dc.subject.meshFactor Xa/analysisen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshOrthopedic Proceduresen_GB
dc.subject.mesh*Thrombelastography/instrumentationen_GB
dc.titleDoes prior administration of enoxaparin influence the effects of levobupivacaine on blood clotting? Assessment using the Thrombelastograph.en_GB
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, and University College, Ireland.en_GB
dc.identifier.journalBritish journal of anaesthesiaen_GB
dc.description.provinceMunster-

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