Lung injury in acute pancreatitis: mechanisms, prevention, and therapy.

Hdl Handle:
http://hdl.handle.net/10147/209017
Title:
Lung injury in acute pancreatitis: mechanisms, prevention, and therapy.
Authors:
Shields, Conor J; Winter, Desmond C; Redmond, H Paul
Affiliation:
Department of Academic Surgery, Cork University Hospital, and National University, of Ireland, Cork, Ireland.
Citation:
Curr Opin Crit Care. 2002 Apr;8(2):158-63.
Journal:
Current opinion in critical care
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209017
PubMed ID:
12386518
Abstract:
Lung injury is the most pertinent manifestation of extra-abdominal organ dysfunction in pancreatitis. The propensity of this retroperitoneal inflammatory condition to engender a diffuse and life-threatening lung injury is significant. Approximately one third of patients will develop acute lung injury and acute respiratory distress syndrome, which account for 60% of all deaths within the first week. The variability in the clinical course of pancreatitis renders it a vexing entity and makes demonstration of the efficacy of any specific intervention difficult. The distinct pathologic entity of pancreatitis-associated lung injury is reviewed with a focus on etiology and potential therapeutic maneuvers.
Language:
eng
MeSH:
Cell Adhesion; Humans; Neutrophil Activation; Neutrophils/immunology/*physiology; Pancreatitis/*complications; Respiratory Distress Syndrome, Adult/*etiology/immunology/therapy; Signal Transduction
ISSN:
1070-5295 (Print); 1070-5295 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorShields, Conor Jen_GB
dc.contributor.authorWinter, Desmond Cen_GB
dc.contributor.authorRedmond, H Paulen_GB
dc.date.accessioned2012-02-03T15:10:02Z-
dc.date.available2012-02-03T15:10:02Z-
dc.date.issued2012-02-03T15:10:02Z-
dc.identifier.citationCurr Opin Crit Care. 2002 Apr;8(2):158-63.en_GB
dc.identifier.issn1070-5295 (Print)en_GB
dc.identifier.issn1070-5295 (Linking)en_GB
dc.identifier.pmid12386518en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209017-
dc.description.abstractLung injury is the most pertinent manifestation of extra-abdominal organ dysfunction in pancreatitis. The propensity of this retroperitoneal inflammatory condition to engender a diffuse and life-threatening lung injury is significant. Approximately one third of patients will develop acute lung injury and acute respiratory distress syndrome, which account for 60% of all deaths within the first week. The variability in the clinical course of pancreatitis renders it a vexing entity and makes demonstration of the efficacy of any specific intervention difficult. The distinct pathologic entity of pancreatitis-associated lung injury is reviewed with a focus on etiology and potential therapeutic maneuvers.en_GB
dc.language.isoengen_GB
dc.subject.meshCell Adhesionen_GB
dc.subject.meshHumansen_GB
dc.subject.meshNeutrophil Activationen_GB
dc.subject.meshNeutrophils/immunology/*physiologyen_GB
dc.subject.meshPancreatitis/*complicationsen_GB
dc.subject.meshRespiratory Distress Syndrome, Adult/*etiology/immunology/therapyen_GB
dc.subject.meshSignal Transductionen_GB
dc.titleLung injury in acute pancreatitis: mechanisms, prevention, and therapy.en_GB
dc.contributor.departmentDepartment of Academic Surgery, Cork University Hospital, and National University, of Ireland, Cork, Ireland.en_GB
dc.identifier.journalCurrent opinion in critical careen_GB
dc.description.provinceMunster-

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