A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy.

Hdl Handle:
http://hdl.handle.net/10147/209013
Title:
A comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy.
Authors:
Awad, Imad T; Murphy, Deirde; Stack, Damian; Swanton, Brian J; Meeke, Rodney I; Shorten, George D
Affiliation:
Department of Anesthesia and Intensive Care Medicine, Cork University Hospital,, Cork, Republic of Ireland.
Citation:
J Clin Anesth. 2002 Nov;14(7):481-5.
Journal:
Journal of clinical anesthesia
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209013
PubMed ID:
12477581
Abstract:
STUDY OBJECTIVES: To compare the prophylactic antiemetic efficacy of the combination of ondansetron and droperidol with that of droperidol alone in patients undergoing elective laparoscopic cholecystectomy. DESIGN: Randomized, double-blind controlled trial. University affiliated teaching hospital after induction of standardized general anesthesia. PATIENTS: 64 ASA physical status I or II patients aged 18 to 80 years, undergoing elective laparoscopic cholecystectomy. INTERVENTION: Following induction of general anesthesia, patients received either droperidol 1.25 mg intravenously (IV; n = 30; Group D) or the combination of droperidol 1.25 mg IV and ondansetron 4 mg IV (n = 34; Group D+O). MEASUREMENTS: Number and severity of nausea episodes, number of emetic episodes, total analgesic consumption, and rescue antiemetic administration were assessed at 1, 3, and 24 hours after admission to the recovery room. Data were analyzed using Fisher's Exact test and unpaired Student's t-test; a p-value <0.05 was considered significant. RESULTS: The proportions of patients who experienced nausea (70% and 53% for D and D+O groups, respectively) and vomiting (30% and 19% for D and D+O groups, respectively) were similar in the two groups. The frequency of moderate and severe nausea (requiring administration of antiemetic) was less in group D + O (7%) compared with group D (19%; p < 0.05). CONCLUSIONS: Patients who received the combination of droperidol and ondansetron experienced less severe nausea compared with patients who received droperidol alone.
Language:
eng
MeSH:
Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia, General; Antiemetics/*therapeutic use; Cholecystectomy, Laparoscopic/*adverse effects; Double-Blind Method; Droperidol/*therapeutic use; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Ondansetron/*therapeutic use; Postoperative Nausea and Vomiting/*drug therapy; Surgical Procedures, Elective
ISSN:
0952-8180 (Print); 0952-8180 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorAwad, Imad Ten_GB
dc.contributor.authorMurphy, Deirdeen_GB
dc.contributor.authorStack, Damianen_GB
dc.contributor.authorSwanton, Brian Jen_GB
dc.contributor.authorMeeke, Rodney Ien_GB
dc.contributor.authorShorten, George Den_GB
dc.date.accessioned2012-02-03T15:09:55Z-
dc.date.available2012-02-03T15:09:55Z-
dc.date.issued2012-02-03T15:09:55Z-
dc.identifier.citationJ Clin Anesth. 2002 Nov;14(7):481-5.en_GB
dc.identifier.issn0952-8180 (Print)en_GB
dc.identifier.issn0952-8180 (Linking)en_GB
dc.identifier.pmid12477581en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209013-
dc.description.abstractSTUDY OBJECTIVES: To compare the prophylactic antiemetic efficacy of the combination of ondansetron and droperidol with that of droperidol alone in patients undergoing elective laparoscopic cholecystectomy. DESIGN: Randomized, double-blind controlled trial. University affiliated teaching hospital after induction of standardized general anesthesia. PATIENTS: 64 ASA physical status I or II patients aged 18 to 80 years, undergoing elective laparoscopic cholecystectomy. INTERVENTION: Following induction of general anesthesia, patients received either droperidol 1.25 mg intravenously (IV; n = 30; Group D) or the combination of droperidol 1.25 mg IV and ondansetron 4 mg IV (n = 34; Group D+O). MEASUREMENTS: Number and severity of nausea episodes, number of emetic episodes, total analgesic consumption, and rescue antiemetic administration were assessed at 1, 3, and 24 hours after admission to the recovery room. Data were analyzed using Fisher's Exact test and unpaired Student's t-test; a p-value <0.05 was considered significant. RESULTS: The proportions of patients who experienced nausea (70% and 53% for D and D+O groups, respectively) and vomiting (30% and 19% for D and D+O groups, respectively) were similar in the two groups. The frequency of moderate and severe nausea (requiring administration of antiemetic) was less in group D + O (7%) compared with group D (19%; p < 0.05). CONCLUSIONS: Patients who received the combination of droperidol and ondansetron experienced less severe nausea compared with patients who received droperidol alone.en_GB
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshAnesthesia, Generalen_GB
dc.subject.meshAntiemetics/*therapeutic useen_GB
dc.subject.meshCholecystectomy, Laparoscopic/*adverse effectsen_GB
dc.subject.meshDouble-Blind Methoden_GB
dc.subject.meshDroperidol/*therapeutic useen_GB
dc.subject.meshDrug Therapy, Combinationen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshOndansetron/*therapeutic useen_GB
dc.subject.meshPostoperative Nausea and Vomiting/*drug therapyen_GB
dc.subject.meshSurgical Procedures, Electiveen_GB
dc.titleA comparison of the effects of droperidol and the combination of droperidol and ondansetron on postoperative nausea and vomiting for patients undergoing laparoscopic cholecystectomy.en_GB
dc.contributor.departmentDepartment of Anesthesia and Intensive Care Medicine, Cork University Hospital,, Cork, Republic of Ireland.en_GB
dc.identifier.journalJournal of clinical anesthesiaen_GB
dc.description.provinceMunster-
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