The prophylactic use of a proton pump inhibitor before food and alcohol.

Hdl Handle:
http://hdl.handle.net/10147/209005
Title:
The prophylactic use of a proton pump inhibitor before food and alcohol.
Authors:
O'Leary, C; McCarthy, J; Humphries, M; Shanahan, F; Quigley, E
Affiliation:
Department of Medicine, Cork University Hospital, Wilton, Cork, Ireland.
Citation:
Aliment Pharmacol Ther. 2003 Mar 1;17(5):683-6.
Journal:
Alimentary pharmacology & therapeutics
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209005
PubMed ID:
12641517
Abstract:
BACKGROUND: Patients report that the prophylactic consumption of a proton pump inhibitor minimizes gastrointestinal symptoms expected to be provoked by late-night food and alcohol consumption. The efficacy of this practice has not been studied formally. AIM: To perform a randomized, double-blind, placebo-controlled trial of a single dose of lansoprazole (30 mg) taken prior to a large meal and alcohol consumption. METHODS: Study subjects were recruited randomly from local primary care and hospital physicians. Each participant (n = 56; 37 male, 19 female; mean age, 38 years) completed questionnaires before and after the meal. Approximately 90 min prior to the provocative meal, participants were witnessed taking either placebo or 30 mg lansoprazole. Bar tokens were dispensed to permit the accurate quantification of alcohol consumption (mean, 15 units). RESULTS: Forty per cent of subjects reported significant reflux symptoms. For the entire group, there was no significant difference between lansoprazole and placebo. Post-prandial reflux was more frequent in those consuming > 15 units of alcohol (13/26, 50%) compared with those consuming < 15 units (7/30, 24%; P < 0.05). In the group who consumed > 15 units of alcohol, lansoprazole was associated with a lower rate of heartburn (5/15, 33%) compared with placebo (8/11, 73%; P < 0.05). CONCLUSION: A single dose of a proton pump inhibitor prior to indulgence was only associated with reduced heartburn in those consuming > 15 units of alcohol.
Language:
eng
MeSH:
2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Alcohol Drinking; Anti-Ulcer Agents/*administration & dosage; Double-Blind Method; Female; Food; Gastroesophageal Reflux/*prevention & control; Humans; Male; Omeprazole/*administration & dosage/analogs & derivatives; Proton Pumps/*antagonists & inhibitors; Treatment Outcome
ISSN:
0269-2813 (Print); 0269-2813 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Leary, Cen_GB
dc.contributor.authorMcCarthy, Jen_GB
dc.contributor.authorHumphries, Men_GB
dc.contributor.authorShanahan, Fen_GB
dc.contributor.authorQuigley, Een_GB
dc.date.accessioned2012-02-03T15:09:42Z-
dc.date.available2012-02-03T15:09:42Z-
dc.date.issued2012-02-03T15:09:42Z-
dc.identifier.citationAliment Pharmacol Ther. 2003 Mar 1;17(5):683-6.en_GB
dc.identifier.issn0269-2813 (Print)en_GB
dc.identifier.issn0269-2813 (Linking)en_GB
dc.identifier.pmid12641517en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209005-
dc.description.abstractBACKGROUND: Patients report that the prophylactic consumption of a proton pump inhibitor minimizes gastrointestinal symptoms expected to be provoked by late-night food and alcohol consumption. The efficacy of this practice has not been studied formally. AIM: To perform a randomized, double-blind, placebo-controlled trial of a single dose of lansoprazole (30 mg) taken prior to a large meal and alcohol consumption. METHODS: Study subjects were recruited randomly from local primary care and hospital physicians. Each participant (n = 56; 37 male, 19 female; mean age, 38 years) completed questionnaires before and after the meal. Approximately 90 min prior to the provocative meal, participants were witnessed taking either placebo or 30 mg lansoprazole. Bar tokens were dispensed to permit the accurate quantification of alcohol consumption (mean, 15 units). RESULTS: Forty per cent of subjects reported significant reflux symptoms. For the entire group, there was no significant difference between lansoprazole and placebo. Post-prandial reflux was more frequent in those consuming > 15 units of alcohol (13/26, 50%) compared with those consuming < 15 units (7/30, 24%; P < 0.05). In the group who consumed > 15 units of alcohol, lansoprazole was associated with a lower rate of heartburn (5/15, 33%) compared with placebo (8/11, 73%; P < 0.05). CONCLUSION: A single dose of a proton pump inhibitor prior to indulgence was only associated with reduced heartburn in those consuming > 15 units of alcohol.en_GB
dc.language.isoengen_GB
dc.subject.mesh2-Pyridinylmethylsulfinylbenzimidazolesen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAlcohol Drinkingen_GB
dc.subject.meshAnti-Ulcer Agents/*administration & dosageen_GB
dc.subject.meshDouble-Blind Methoden_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFooden_GB
dc.subject.meshGastroesophageal Reflux/*prevention & controlen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshOmeprazole/*administration & dosage/analogs & derivativesen_GB
dc.subject.meshProton Pumps/*antagonists & inhibitorsen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleThe prophylactic use of a proton pump inhibitor before food and alcohol.en_GB
dc.contributor.departmentDepartment of Medicine, Cork University Hospital, Wilton, Cork, Ireland.en_GB
dc.identifier.journalAlimentary pharmacology & therapeuticsen_GB
dc.description.provinceMunster-
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