Factors that influence therapeutic outcomes in symptomatic gastroesophageal reflux disease.

Hdl Handle:
http://hdl.handle.net/10147/209004
Title:
Factors that influence therapeutic outcomes in symptomatic gastroesophageal reflux disease.
Authors:
Quigley, Eamonn M M
Affiliation:
Department of Medicine, Clinical Sciences Building, Cork University Hospital,, National University of Ireland, Wilton Road, Cork, Ireland.
Citation:
Am J Gastroenterol. 2003 Mar;98(3 Suppl):S24-30.
Journal:
The American journal of gastroenterology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/209004
PubMed ID:
12644028
Abstract:
The term "symptomatic gastroesophageal reflux disease" (GERD) refers to those patients who present with the typical GERD symptoms of heartburn and regurgitation, yet do not have endoscopic evidence of esophagitis. The primary goals of managing symptomatic GERD are to control symptoms and improve quality of life. A clinical assessment of the GERD patient can identify important clinical features, such as atypical and extraesophageal symptoms for which acid-suppressive agents tend to be less effective. Performing an endoscopy can further identify the patient as having nonerosive reflux disease, erosive esophagitis, or Barrett's esophagus-diagnoses which can help determine treatment but may not prove predictive of therapeutic response. Determining acid exposure through pH testing can predict therapeutic response, with those revealing an abnormal acid exposure time being more responsive to acid-suppressive therapy. However, the performance of an endoscopy and pH testing on each patient is clearly not practical. Whereas the natural history of symptomatic GERD is still largely undefined, acid-suppressive therapy appears to be the best approach available for both the short-term and long-term management of this disease.
Language:
eng
MeSH:
Clinical Trials as Topic; Esophagoscopy/methods; Fundoplication/methods; Gastric Acidity Determination; Gastroesophageal Reflux/diagnosis/*therapy; Gastrointestinal Agents/*therapeutic use; Humans; Treatment Outcome
ISSN:
0002-9270 (Print); 0002-9270 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorQuigley, Eamonn M Men_GB
dc.date.accessioned2012-02-03T15:09:41Z-
dc.date.available2012-02-03T15:09:41Z-
dc.date.issued2012-02-03T15:09:41Z-
dc.identifier.citationAm J Gastroenterol. 2003 Mar;98(3 Suppl):S24-30.en_GB
dc.identifier.issn0002-9270 (Print)en_GB
dc.identifier.issn0002-9270 (Linking)en_GB
dc.identifier.pmid12644028en_GB
dc.identifier.urihttp://hdl.handle.net/10147/209004-
dc.description.abstractThe term "symptomatic gastroesophageal reflux disease" (GERD) refers to those patients who present with the typical GERD symptoms of heartburn and regurgitation, yet do not have endoscopic evidence of esophagitis. The primary goals of managing symptomatic GERD are to control symptoms and improve quality of life. A clinical assessment of the GERD patient can identify important clinical features, such as atypical and extraesophageal symptoms for which acid-suppressive agents tend to be less effective. Performing an endoscopy can further identify the patient as having nonerosive reflux disease, erosive esophagitis, or Barrett's esophagus-diagnoses which can help determine treatment but may not prove predictive of therapeutic response. Determining acid exposure through pH testing can predict therapeutic response, with those revealing an abnormal acid exposure time being more responsive to acid-suppressive therapy. However, the performance of an endoscopy and pH testing on each patient is clearly not practical. Whereas the natural history of symptomatic GERD is still largely undefined, acid-suppressive therapy appears to be the best approach available for both the short-term and long-term management of this disease.en_GB
dc.language.isoengen_GB
dc.subject.meshClinical Trials as Topicen_GB
dc.subject.meshEsophagoscopy/methodsen_GB
dc.subject.meshFundoplication/methodsen_GB
dc.subject.meshGastric Acidity Determinationen_GB
dc.subject.meshGastroesophageal Reflux/diagnosis/*therapyen_GB
dc.subject.meshGastrointestinal Agents/*therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleFactors that influence therapeutic outcomes in symptomatic gastroesophageal reflux disease.en_GB
dc.contributor.departmentDepartment of Medicine, Clinical Sciences Building, Cork University Hospital,, National University of Ireland, Wilton Road, Cork, Ireland.en_GB
dc.identifier.journalThe American journal of gastroenterologyen_GB
dc.description.provinceMunster-
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