Neuraxial opioid-induced pruritus: a review.

Hdl Handle:
http://hdl.handle.net/10147/208998
Title:
Neuraxial opioid-induced pruritus: a review.
Authors:
Szarvas, Szilvia; Harmon, Dominic; Murphy, Damian
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , Wilton Road, Cork, Ireland. szarvasszilvia@hotmail.com
Citation:
J Clin Anesth. 2003 May;15(3):234-9.
Journal:
Journal of clinical anesthesia
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208998
PubMed ID:
12770663
Abstract:
When intrathecal and epidural opioids are administered, pruritus occurs as an unwanted and troublesome side effect. The reported incidence varies between 30% and 100%. The exact mechanisms of neuraxial opioid-induced pruritus remain unclear. Postulated mechanisms include the presence of an "itch center" in the central nervous system, medullary dorsal horn activation, and antagonism of inhibitory transmitters. The treatment of intrathecal opioid-induced pruritus remains a challenge. Many pharmacological therapies, including antihistamines, 5-HT(3)-receptor antagonists, opiate-antagonists, propofol, nonsteroid antiinflammatory drugs, and droperidol, have been studied. In this review, we will summarize pathophysiological and pharmacological advances that will improve understanding and ultimately the management of this troublesome problem.
Language:
eng
MeSH:
Analgesics, Opioid/administration & dosage/*adverse effects; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use; Humans; Narcotic Antagonists/therapeutic use; Nerve Block/*adverse effects; Pruritus/*chemically induced/drug therapy/physiopathology; Serotonin Antagonists/therapeutic use
ISSN:
0952-8180 (Print); 0952-8180 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorSzarvas, Szilviaen_GB
dc.contributor.authorHarmon, Dominicen_GB
dc.contributor.authorMurphy, Damianen_GB
dc.date.accessioned2012-02-03T15:09:32Z-
dc.date.available2012-02-03T15:09:32Z-
dc.date.issued2012-02-03T15:09:32Z-
dc.identifier.citationJ Clin Anesth. 2003 May;15(3):234-9.en_GB
dc.identifier.issn0952-8180 (Print)en_GB
dc.identifier.issn0952-8180 (Linking)en_GB
dc.identifier.pmid12770663en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208998-
dc.description.abstractWhen intrathecal and epidural opioids are administered, pruritus occurs as an unwanted and troublesome side effect. The reported incidence varies between 30% and 100%. The exact mechanisms of neuraxial opioid-induced pruritus remain unclear. Postulated mechanisms include the presence of an "itch center" in the central nervous system, medullary dorsal horn activation, and antagonism of inhibitory transmitters. The treatment of intrathecal opioid-induced pruritus remains a challenge. Many pharmacological therapies, including antihistamines, 5-HT(3)-receptor antagonists, opiate-antagonists, propofol, nonsteroid antiinflammatory drugs, and droperidol, have been studied. In this review, we will summarize pathophysiological and pharmacological advances that will improve understanding and ultimately the management of this troublesome problem.en_GB
dc.language.isoengen_GB
dc.subject.meshAnalgesics, Opioid/administration & dosage/*adverse effectsen_GB
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal/therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshNarcotic Antagonists/therapeutic useen_GB
dc.subject.meshNerve Block/*adverse effectsen_GB
dc.subject.meshPruritus/*chemically induced/drug therapy/physiopathologyen_GB
dc.subject.meshSerotonin Antagonists/therapeutic useen_GB
dc.titleNeuraxial opioid-induced pruritus: a review.en_GB
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , Wilton Road, Cork, Ireland. szarvasszilvia@hotmail.comen_GB
dc.identifier.journalJournal of clinical anesthesiaen_GB
dc.description.provinceMunster-

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