Behaviour of spectral entropy, spectral edge frequency 90%, and alpha and beta power parameters during low-dose propofol infusion.

Hdl Handle:
http://hdl.handle.net/10147/208984
Title:
Behaviour of spectral entropy, spectral edge frequency 90%, and alpha and beta power parameters during low-dose propofol infusion.
Authors:
Mahon, P; Greene, B R; Greene, C; Boylan, G B; Shorten, G D
Affiliation:
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , Cork, Ireland. rsimahon@hotmail.com
Citation:
Br J Anaesth. 2008 Aug;101(2):213-21. Epub 2008 Jun 11.
Journal:
British journal of anaesthesia
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208984
DOI:
10.1093/bja/aen161
PubMed ID:
18550642
Abstract:
BACKGROUND: In this study we analyse the behaviour, potential clinical application and optimal cortical sampling location of the spectral parameters: (i) relative alpha and beta power; (ii) spectral edge frequency 90%; and (iii) spectral entropy as monitors of moderate propofol-induced sedation. METHODS: Multi-channel EEG recorded from 12 ASA 1 (American Society of Anesthesiologists physical status 1) patients during low-dose, target effect-site controlled propofol infusion was used for this analysis. The initial target effect-site concentration was 0.5 microg ml(-1) and increased at 4 min intervals in increments of 0.5 to 2 microg ml(-1). EEG parameters were calculated for 2 s epochs in the frequency ranges 0.5-32 and 0.5-47 Hz. All parameters were calculated in the channels: P4-O2, P3-O1, F4-C4, F3-C3, F3-F4, and Fp1-Fp2. Sedation was assessed clinically using the OAA/S (observer's assessment of alertness/sedation) scale. RESULTS: Relative beta power and spectral entropy increased with increasing propofol effect-site concentration in both the 0.5-47 Hz [F(18, 90) = 3.455, P<0.05 and F(18, 90) = 3.33, P<0.05, respectively] and 0.5-32 Hz frequency range. This effect was significant in each individual channel (P<0.05). No effect was seen of increasing effect-site concentration on relative power in the alpha band. Averaged across all channels, spectral entropy did not outperform relative beta power in either the 0.5-32 Hz [Pk=0.79 vs 0.814 (P>0.05)] or 0.5-47 Hz range [Pk=0.81 vs 0.82 (P>0.05)]. The best performing indicator in any single channel was spectral entropy in the frequency range 0.5-47 Hz in the frontal channel F3-F4 (Pk=0.85). CONCLUSIONS: Relative beta power and spectral entropy when considered over the propofol effect-site range studied here increase in value, and correlate well with clinical assessment of sedation.
Language:
eng
MeSH:
Adolescent; Adult; Aged; Conscious Sedation/methods; Dose-Response Relationship, Drug; Electroencephalography/*drug effects/methods; Entropy; Humans; Hypnotics and Sedatives/administration & dosage/*pharmacology; Middle Aged; Monitoring, Intraoperative/methods; Propofol/administration & dosage/*pharmacology; Signal Processing, Computer-Assisted
ISSN:
1471-6771 (Electronic); 0007-0912 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMahon, Pen_GB
dc.contributor.authorGreene, B Ren_GB
dc.contributor.authorGreene, Cen_GB
dc.contributor.authorBoylan, G Ben_GB
dc.contributor.authorShorten, G Den_GB
dc.date.accessioned2012-02-03T15:09:11Z-
dc.date.available2012-02-03T15:09:11Z-
dc.date.issued2012-02-03T15:09:11Z-
dc.identifier.citationBr J Anaesth. 2008 Aug;101(2):213-21. Epub 2008 Jun 11.en_GB
dc.identifier.issn1471-6771 (Electronic)en_GB
dc.identifier.issn0007-0912 (Linking)en_GB
dc.identifier.pmid18550642en_GB
dc.identifier.doi10.1093/bja/aen161en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208984-
dc.description.abstractBACKGROUND: In this study we analyse the behaviour, potential clinical application and optimal cortical sampling location of the spectral parameters: (i) relative alpha and beta power; (ii) spectral edge frequency 90%; and (iii) spectral entropy as monitors of moderate propofol-induced sedation. METHODS: Multi-channel EEG recorded from 12 ASA 1 (American Society of Anesthesiologists physical status 1) patients during low-dose, target effect-site controlled propofol infusion was used for this analysis. The initial target effect-site concentration was 0.5 microg ml(-1) and increased at 4 min intervals in increments of 0.5 to 2 microg ml(-1). EEG parameters were calculated for 2 s epochs in the frequency ranges 0.5-32 and 0.5-47 Hz. All parameters were calculated in the channels: P4-O2, P3-O1, F4-C4, F3-C3, F3-F4, and Fp1-Fp2. Sedation was assessed clinically using the OAA/S (observer's assessment of alertness/sedation) scale. RESULTS: Relative beta power and spectral entropy increased with increasing propofol effect-site concentration in both the 0.5-47 Hz [F(18, 90) = 3.455, P<0.05 and F(18, 90) = 3.33, P<0.05, respectively] and 0.5-32 Hz frequency range. This effect was significant in each individual channel (P<0.05). No effect was seen of increasing effect-site concentration on relative power in the alpha band. Averaged across all channels, spectral entropy did not outperform relative beta power in either the 0.5-32 Hz [Pk=0.79 vs 0.814 (P>0.05)] or 0.5-47 Hz range [Pk=0.81 vs 0.82 (P>0.05)]. The best performing indicator in any single channel was spectral entropy in the frequency range 0.5-47 Hz in the frontal channel F3-F4 (Pk=0.85). CONCLUSIONS: Relative beta power and spectral entropy when considered over the propofol effect-site range studied here increase in value, and correlate well with clinical assessment of sedation.en_GB
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshConscious Sedation/methodsen_GB
dc.subject.meshDose-Response Relationship, Drugen_GB
dc.subject.meshElectroencephalography/*drug effects/methodsen_GB
dc.subject.meshEntropyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypnotics and Sedatives/administration & dosage/*pharmacologyen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMonitoring, Intraoperative/methodsen_GB
dc.subject.meshPropofol/administration & dosage/*pharmacologyen_GB
dc.subject.meshSignal Processing, Computer-Assisteden_GB
dc.titleBehaviour of spectral entropy, spectral edge frequency 90%, and alpha and beta power parameters during low-dose propofol infusion.en_GB
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care Medicine, Cork University Hospital, , Cork, Ireland. rsimahon@hotmail.comen_GB
dc.identifier.journalBritish journal of anaesthesiaen_GB
dc.description.provinceMunster-
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