Excisional surgery for cancer cure: therapy at a cost.

Hdl Handle:
http://hdl.handle.net/10147/208975
Title:
Excisional surgery for cancer cure: therapy at a cost.
Authors:
Coffey, J C; Wang, J H; Smith, M J F; Bouchier-Hayes, D; Cotter, T G; Redmond, H P
Affiliation:
Department of Surgery, Cork University Hospital and University College Cork,, Ireland. calvincoffey@hotmail.com
Citation:
Lancet Oncol. 2003 Dec;4(12):760-8.
Journal:
The lancet oncology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208975
PubMed ID:
14662433
Abstract:
Excisional surgery is one of the primary treatment modalities for cancer. Minimal residual disease (MRD) is the occult neoplastic disease that remains in situ after curative surgery. There is increasing evidence that tumour removal alters the growth of MRD, leading to perioperative tumour growth. Because neoplasia is a systemic disease, this phenomenon may be relevant to all patients undergoing surgery for cancer. In this review we discuss the published work that addresses the effects of tumour removal on subsequent tumour growth and the mechanisms by which tumour excision may alter residual tumour growth. In addition, we describe therapeutic approaches that may protect patients against any oncologically adverse effects of tumour removal. On the basis of the evidence presented, we propose a novel therapeutic paradigm; that the postoperative period represents a window of opportunity during which the patient may be further protected against the oncological effects of tumour removal.
Language:
eng
MeSH:
Chemotherapy, Adjuvant; Humans; Lymphatic Metastasis; Neoplasm, Residual/drug therapy/*pathology; Neoplasms/drug therapy/*pathology/*surgery; Surgical Procedures, Operative/*adverse effects
ISSN:
1470-2045 (Print); 1470-2045 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCoffey, J Cen_GB
dc.contributor.authorWang, J Hen_GB
dc.contributor.authorSmith, M J Fen_GB
dc.contributor.authorBouchier-Hayes, Den_GB
dc.contributor.authorCotter, T Gen_GB
dc.contributor.authorRedmond, H Pen_GB
dc.date.accessioned2012-02-03T15:08:56Z-
dc.date.available2012-02-03T15:08:56Z-
dc.date.issued2012-02-03T15:08:56Z-
dc.identifier.citationLancet Oncol. 2003 Dec;4(12):760-8.en_GB
dc.identifier.issn1470-2045 (Print)en_GB
dc.identifier.issn1470-2045 (Linking)en_GB
dc.identifier.pmid14662433en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208975-
dc.description.abstractExcisional surgery is one of the primary treatment modalities for cancer. Minimal residual disease (MRD) is the occult neoplastic disease that remains in situ after curative surgery. There is increasing evidence that tumour removal alters the growth of MRD, leading to perioperative tumour growth. Because neoplasia is a systemic disease, this phenomenon may be relevant to all patients undergoing surgery for cancer. In this review we discuss the published work that addresses the effects of tumour removal on subsequent tumour growth and the mechanisms by which tumour excision may alter residual tumour growth. In addition, we describe therapeutic approaches that may protect patients against any oncologically adverse effects of tumour removal. On the basis of the evidence presented, we propose a novel therapeutic paradigm; that the postoperative period represents a window of opportunity during which the patient may be further protected against the oncological effects of tumour removal.en_GB
dc.language.isoengen_GB
dc.subject.meshChemotherapy, Adjuvanten_GB
dc.subject.meshHumansen_GB
dc.subject.meshLymphatic Metastasisen_GB
dc.subject.meshNeoplasm, Residual/drug therapy/*pathologyen_GB
dc.subject.meshNeoplasms/drug therapy/*pathology/*surgeryen_GB
dc.subject.meshSurgical Procedures, Operative/*adverse effectsen_GB
dc.titleExcisional surgery for cancer cure: therapy at a cost.en_GB
dc.contributor.departmentDepartment of Surgery, Cork University Hospital and University College Cork,, Ireland. calvincoffey@hotmail.comen_GB
dc.identifier.journalThe lancet oncologyen_GB
dc.description.provinceMunster-

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