Creutzfeldt-Jakob disease in Ireland: epidemiological aspects 1980-2002.

Hdl Handle:
http://hdl.handle.net/10147/208963
Title:
Creutzfeldt-Jakob disease in Ireland: epidemiological aspects 1980-2002.
Authors:
Horan, Gail; Keohane, Catherine; Molloy, Sophie; Howley, Rachel; Harney, Michael; Heffernan, Josephine; McGuigan, Christopher; Hutchinson, Michael; Brett, Francesca; Farrell, Michael
Affiliation:
Department of Neuropathology, Cork University Hospital, Cork, Ireland.
Citation:
Eur Neurol. 2004;51(3):132-7. Epub 2004 Feb 26.
Journal:
European neurology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208963
DOI:
10.1159/000077063
PubMed ID:
14988606
Abstract:
Surveillance for Creutzfeldt-Jakob disease (CJD) has been carried out in the Republic of Ireland since 1980. Initial surveillance was passive and based on consented autopsy confirmation of CJD in patients in whom there was a high index of clinical suspicion. Since 1999, an active surveillance programme involving formal notification of all suspect CJD cases has been in place. The annual mortality rate has increased from 0.34 cases/million in 1980 to 1.27 cases/million in 2001. In all, 29 cases have been pathologically confirmed: 1 had variant CJD (vCJD), 1 had iatrogenic human growth hormone-induced CJD and 1 had fatal insomnia. Sporadic CJD (sCJD) accounted for the remainder. This paper details the change in incidence over 22 years as the surveillance programme in Ireland got under way; the increased incidence is attributed to better case ascertainment, as has occurred in other countries where active surveillance programmes have been established.
Language:
eng
MeSH:
Adult; Age Distribution; Aged; Creutzfeldt-Jakob Syndrome/*epidemiology; *Epidemiologic Studies; Female; Humans; Ireland/epidemiology; Male; Middle Aged; Population Surveillance; Prospective Studies; Retrospective Studies; Risk Factors; Sex Distribution
ISSN:
0014-3022 (Print); 0014-3022 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorHoran, Gailen_GB
dc.contributor.authorKeohane, Catherineen_GB
dc.contributor.authorMolloy, Sophieen_GB
dc.contributor.authorHowley, Rachelen_GB
dc.contributor.authorHarney, Michaelen_GB
dc.contributor.authorHeffernan, Josephineen_GB
dc.contributor.authorMcGuigan, Christopheren_GB
dc.contributor.authorHutchinson, Michaelen_GB
dc.contributor.authorBrett, Francescaen_GB
dc.contributor.authorFarrell, Michaelen_GB
dc.date.accessioned2012-02-03T15:08:38Z-
dc.date.available2012-02-03T15:08:38Z-
dc.date.issued2012-02-03T15:08:38Z-
dc.identifier.citationEur Neurol. 2004;51(3):132-7. Epub 2004 Feb 26.en_GB
dc.identifier.issn0014-3022 (Print)en_GB
dc.identifier.issn0014-3022 (Linking)en_GB
dc.identifier.pmid14988606en_GB
dc.identifier.doi10.1159/000077063en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208963-
dc.description.abstractSurveillance for Creutzfeldt-Jakob disease (CJD) has been carried out in the Republic of Ireland since 1980. Initial surveillance was passive and based on consented autopsy confirmation of CJD in patients in whom there was a high index of clinical suspicion. Since 1999, an active surveillance programme involving formal notification of all suspect CJD cases has been in place. The annual mortality rate has increased from 0.34 cases/million in 1980 to 1.27 cases/million in 2001. In all, 29 cases have been pathologically confirmed: 1 had variant CJD (vCJD), 1 had iatrogenic human growth hormone-induced CJD and 1 had fatal insomnia. Sporadic CJD (sCJD) accounted for the remainder. This paper details the change in incidence over 22 years as the surveillance programme in Ireland got under way; the increased incidence is attributed to better case ascertainment, as has occurred in other countries where active surveillance programmes have been established.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAge Distributionen_GB
dc.subject.meshAgeden_GB
dc.subject.meshCreutzfeldt-Jakob Syndrome/*epidemiologyen_GB
dc.subject.mesh*Epidemiologic Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPopulation Surveillanceen_GB
dc.subject.meshProspective Studiesen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshSex Distributionen_GB
dc.titleCreutzfeldt-Jakob disease in Ireland: epidemiological aspects 1980-2002.en_GB
dc.contributor.departmentDepartment of Neuropathology, Cork University Hospital, Cork, Ireland.en_GB
dc.identifier.journalEuropean neurologyen_GB
dc.description.provinceMunster-

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