Postoperative changes in the full-field electroretinogram following sevoflurane anaesthesia.

Hdl Handle:
http://hdl.handle.net/10147/208957
Title:
Postoperative changes in the full-field electroretinogram following sevoflurane anaesthesia.
Authors:
Iohom, G; Whyte, A; Flynn, T; O'Connor, G; Shorten, G
Affiliation:
Cork University Hospital and University College Cork, Department of Anaesthesia, and Intensive Care Medicine, Cork, Ireland. iohom@hotmail.com
Citation:
Eur J Anaesthesiol. 2004 Apr;21(4):272-8.
Journal:
European journal of anaesthesiology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208957
PubMed ID:
15109189
Abstract:
BACKGROUND AND OBJECTIVE: We tested the hypothesis that disturbances of the visual pathway persist following general anaesthesia, even after normal clinical discharge criteria have been met. METHODS: We performed full-field flash electroretinography in the right eye of 10 unpremedicated ASA I patients who underwent N2O/sevoflurane anaesthesia. Electroretinograms were recorded preoperatively, immediately after discharge from the recovery room and 2 h after discontinuation of sevoflurane. The time at which postanaesthesia discharge score first exceeded 9 was also noted. Data were analysed using paired, one-tailed Student's t-test. RESULTS: Latency of the b-wave on the photopic electroretinogram was greater at each postoperative time point (30.5 +/- 0.9 and 30 +/- 1.3 ms), compared to preoperative values (29.2 +/- 0.8 ms, P < 0.001 and P = 0.04, respectively). The A-B amplitude of the b-wave was less postoperatively (220.3 +/- 52.7 and 210.3 +/- 42.7 pV) compared to values before operation (248.1 +/- 57.6 microV, P = 0.03 and P = 0.01, respectively). Oscillatory potential latencies were greater at each postoperative time point (21.4 +/- 0.5 and 20.8 +/- 0.6 ms) compared to before operation (20.4 +/- 0.4 ms, P < 0.001 and P = 0.03, respectively). Oscillatory potential amplitudes were less at the first postoperative time point (17.5 +/- 6.1 microV), compared to preoperative values (22 +/- 6.4 microV, P = 0.04). CONCLUSIONS: Postoperative electroretinogram abnormalities are consistently present in patients who have undergone N2O/sevoflurane anaesthesia. These abnormalities persist beyond the time at which standard clinical discharge criteria have been met.
Language:
eng
MeSH:
Adult; Anesthesia Recovery Period; Anesthetics, Inhalation/*administration & dosage; Chi-Square Distribution; Electroretinography/*drug effects; Evoked Potentials/drug effects; Female; Follow-Up Studies; Humans; Male; Matched-Pair Analysis; Methyl Ethers/*administration & dosage; Middle Aged; Nitrous Oxide/administration & dosage; Postoperative Period; Reaction Time/drug effects; Recovery of Function; Time Factors; Visual Pathways/drug effects
ISSN:
0265-0215 (Print); 0265-0215 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorIohom, Gen_GB
dc.contributor.authorWhyte, Aen_GB
dc.contributor.authorFlynn, Ten_GB
dc.contributor.authorO'Connor, Gen_GB
dc.contributor.authorShorten, Gen_GB
dc.date.accessioned2012-02-03T15:08:27Z-
dc.date.available2012-02-03T15:08:27Z-
dc.date.issued2012-02-03T15:08:27Z-
dc.identifier.citationEur J Anaesthesiol. 2004 Apr;21(4):272-8.en_GB
dc.identifier.issn0265-0215 (Print)en_GB
dc.identifier.issn0265-0215 (Linking)en_GB
dc.identifier.pmid15109189en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208957-
dc.description.abstractBACKGROUND AND OBJECTIVE: We tested the hypothesis that disturbances of the visual pathway persist following general anaesthesia, even after normal clinical discharge criteria have been met. METHODS: We performed full-field flash electroretinography in the right eye of 10 unpremedicated ASA I patients who underwent N2O/sevoflurane anaesthesia. Electroretinograms were recorded preoperatively, immediately after discharge from the recovery room and 2 h after discontinuation of sevoflurane. The time at which postanaesthesia discharge score first exceeded 9 was also noted. Data were analysed using paired, one-tailed Student's t-test. RESULTS: Latency of the b-wave on the photopic electroretinogram was greater at each postoperative time point (30.5 +/- 0.9 and 30 +/- 1.3 ms), compared to preoperative values (29.2 +/- 0.8 ms, P < 0.001 and P = 0.04, respectively). The A-B amplitude of the b-wave was less postoperatively (220.3 +/- 52.7 and 210.3 +/- 42.7 pV) compared to values before operation (248.1 +/- 57.6 microV, P = 0.03 and P = 0.01, respectively). Oscillatory potential latencies were greater at each postoperative time point (21.4 +/- 0.5 and 20.8 +/- 0.6 ms) compared to before operation (20.4 +/- 0.4 ms, P < 0.001 and P = 0.03, respectively). Oscillatory potential amplitudes were less at the first postoperative time point (17.5 +/- 6.1 microV), compared to preoperative values (22 +/- 6.4 microV, P = 0.04). CONCLUSIONS: Postoperative electroretinogram abnormalities are consistently present in patients who have undergone N2O/sevoflurane anaesthesia. These abnormalities persist beyond the time at which standard clinical discharge criteria have been met.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnesthesia Recovery Perioden_GB
dc.subject.meshAnesthetics, Inhalation/*administration & dosageen_GB
dc.subject.meshChi-Square Distributionen_GB
dc.subject.meshElectroretinography/*drug effectsen_GB
dc.subject.meshEvoked Potentials/drug effectsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFollow-Up Studiesen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMatched-Pair Analysisen_GB
dc.subject.meshMethyl Ethers/*administration & dosageen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshNitrous Oxide/administration & dosageen_GB
dc.subject.meshPostoperative Perioden_GB
dc.subject.meshReaction Time/drug effectsen_GB
dc.subject.meshRecovery of Functionen_GB
dc.subject.meshTime Factorsen_GB
dc.subject.meshVisual Pathways/drug effectsen_GB
dc.titlePostoperative changes in the full-field electroretinogram following sevoflurane anaesthesia.en_GB
dc.contributor.departmentCork University Hospital and University College Cork, Department of Anaesthesia, and Intensive Care Medicine, Cork, Ireland. iohom@hotmail.comen_GB
dc.identifier.journalEuropean journal of anaesthesiologyen_GB
dc.description.provinceMunster-

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