Persistence of hepatitis C virus in a white population: associations with human leukocyte antigen class 1.

Hdl Handle:
http://hdl.handle.net/10147/208949
Title:
Persistence of hepatitis C virus in a white population: associations with human leukocyte antigen class 1.
Authors:
Fanning, Liam J; Kenny-Walsh, Elizabeth; Shanahan, Fergus
Affiliation:
Hepatitis C Unit, Department of Medicine, Clinical Sciences Building, Cork, University Hospital, National University of Ireland, Cork, Ireland., 1.fanning@ucc.ie
Citation:
Hum Immunol. 2004 Jul;65(7):745-51.
Journal:
Human immunology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208949
DOI:
10.1016/j.humimm.2004.05.001
PubMed ID:
15301865
Abstract:
The aim of this study was to define novel associations between human leukocyte antigen (HLA) class 1 alleles and persistence or clearance of the hepatitis C virus (HCV) in a white population. All individuals in the study were seropositive for anti-HCV antibodies. Viral status was determined by the Roche HCV Amplicor test. HLA-A, -B, -C allelic group profile was molecularly defined by reverse line probe hybridization. The strongest individual allelic group associations with persistent HCV infection were HLA A*11 (p = 0.044) and Cw*04 (p = 0.006). However, only the HLA C*04 association survived correction for multiple comparisons. Further analysis of alleles in linkage with HLA Cw*04 revealed that the haplotype HLA A*11, Cw*04 was present in 11 individuals, 10 of whom were viremic (p = 0.05). No gene dosage effect was observed. No association between HLA class 1 allelic groups and aviremia and virus load was evident in this white population. HLA B*44 is associated with low virus load in human immunodeficiency virus disease, but this association was not evident in this HCV-infected population. Novel HLA class 1 alleles associated with persistence of HCV have been identified.
Language:
eng
MeSH:
DNA/genetics/isolation & purification; Data Interpretation, Statistical; European Continental Ancestry Group/*genetics; Female; Gene Frequency/genetics; Genotype; HLA-A Antigens/genetics; HLA-B Antigens/genetics; HLA-C Antigens/genetics; Haplotypes/genetics; Hepacivirus/genetics/immunology; Hepatitis C, Chronic/blood/*genetics/immunology; Heterozygote; Histocompatibility Antigens Class I/*genetics; Homozygote; Humans; Ireland; Male; Polymerase Chain Reaction; Polymorphism, Genetic/*genetics; Viral Load
ISSN:
0198-8859 (Print); 0198-8859 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorFanning, Liam Jen_GB
dc.contributor.authorKenny-Walsh, Elizabethen_GB
dc.contributor.authorShanahan, Fergusen_GB
dc.date.accessioned2012-02-03T15:08:15Z-
dc.date.available2012-02-03T15:08:15Z-
dc.date.issued2012-02-03T15:08:15Z-
dc.identifier.citationHum Immunol. 2004 Jul;65(7):745-51.en_GB
dc.identifier.issn0198-8859 (Print)en_GB
dc.identifier.issn0198-8859 (Linking)en_GB
dc.identifier.pmid15301865en_GB
dc.identifier.doi10.1016/j.humimm.2004.05.001en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208949-
dc.description.abstractThe aim of this study was to define novel associations between human leukocyte antigen (HLA) class 1 alleles and persistence or clearance of the hepatitis C virus (HCV) in a white population. All individuals in the study were seropositive for anti-HCV antibodies. Viral status was determined by the Roche HCV Amplicor test. HLA-A, -B, -C allelic group profile was molecularly defined by reverse line probe hybridization. The strongest individual allelic group associations with persistent HCV infection were HLA A*11 (p = 0.044) and Cw*04 (p = 0.006). However, only the HLA C*04 association survived correction for multiple comparisons. Further analysis of alleles in linkage with HLA Cw*04 revealed that the haplotype HLA A*11, Cw*04 was present in 11 individuals, 10 of whom were viremic (p = 0.05). No gene dosage effect was observed. No association between HLA class 1 allelic groups and aviremia and virus load was evident in this white population. HLA B*44 is associated with low virus load in human immunodeficiency virus disease, but this association was not evident in this HCV-infected population. Novel HLA class 1 alleles associated with persistence of HCV have been identified.en_GB
dc.language.isoengen_GB
dc.subject.meshDNA/genetics/isolation & purificationen_GB
dc.subject.meshData Interpretation, Statisticalen_GB
dc.subject.meshEuropean Continental Ancestry Group/*geneticsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGene Frequency/geneticsen_GB
dc.subject.meshGenotypeen_GB
dc.subject.meshHLA-A Antigens/geneticsen_GB
dc.subject.meshHLA-B Antigens/geneticsen_GB
dc.subject.meshHLA-C Antigens/geneticsen_GB
dc.subject.meshHaplotypes/geneticsen_GB
dc.subject.meshHepacivirus/genetics/immunologyen_GB
dc.subject.meshHepatitis C, Chronic/blood/*genetics/immunologyen_GB
dc.subject.meshHeterozygoteen_GB
dc.subject.meshHistocompatibility Antigens Class I/*geneticsen_GB
dc.subject.meshHomozygoteen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIrelanden_GB
dc.subject.meshMaleen_GB
dc.subject.meshPolymerase Chain Reactionen_GB
dc.subject.meshPolymorphism, Genetic/*geneticsen_GB
dc.subject.meshViral Loaden_GB
dc.titlePersistence of hepatitis C virus in a white population: associations with human leukocyte antigen class 1.en_GB
dc.contributor.departmentHepatitis C Unit, Department of Medicine, Clinical Sciences Building, Cork, University Hospital, National University of Ireland, Cork, Ireland., 1.fanning@ucc.ieen_GB
dc.identifier.journalHuman immunologyen_GB
dc.description.provinceMunster-

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