Cytokines: abnormalities in major depression and implications for pharmacological treatment.

Hdl Handle:
http://hdl.handle.net/10147/208948
Title:
Cytokines: abnormalities in major depression and implications for pharmacological treatment.
Authors:
O'Brien, Sinead M; Scott, Lucinda V; Dinan, Timothy G
Affiliation:
Department of Psychiatry, University College Cork, Cork University Hospital,, Wilton Road, Cork, Ireland.
Citation:
Hum Psychopharmacol. 2004 Aug;19(6):397-403.
Journal:
Human psychopharmacology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208948
DOI:
10.1002/hup.609
PubMed ID:
15303243
Abstract:
The role of cytokines in depression was first considered when the cytokine interferon resulted in "sickness behaviour", the symptoms of which are similar to those of major depression. The latter is associated with an increase in pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-alpha). These cytokines are potent modulators of corticotropin-releasing hormone (CRH) which produces heightened hypothalamic-pituitary-adrenal axis (HPA) activity characterized by increases in ACTH and cortisol, both of which are reported elevated in major depression. Antidepressant treatment has immunomodulatory effects with increases in the production of IL-10, which is an anti-inflammatory cytokine. This review based on a Medline search from 1980-2003, focuses on the evidence available of cytokine changes in acute stress, chronic stress and major depression. It examines the effects of antidepressant treatment on immune parameters in both animal models and clinical trials. We suggest that future antidepressants may target the immune system by either blocking the actions of pro-inflammatory cytokines or increasing the production of anti-inflammatory cytokines.
Language:
eng
MeSH:
Antidepressive Agents/*therapeutic use; Cytokines/*metabolism; Depressive Disorder, Major/*drug therapy/immunology/*metabolism; Humans; Immune System/metabolism; Neurosecretory Systems/metabolism; Serotonin/metabolism; Stress, Physiological/immunology/metabolism
ISSN:
0885-6222 (Print); 0885-6222 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Brien, Sinead Men_GB
dc.contributor.authorScott, Lucinda Ven_GB
dc.contributor.authorDinan, Timothy Gen_GB
dc.date.accessioned2012-02-03T15:08:13Z-
dc.date.available2012-02-03T15:08:13Z-
dc.date.issued2012-02-03T15:08:13Z-
dc.identifier.citationHum Psychopharmacol. 2004 Aug;19(6):397-403.en_GB
dc.identifier.issn0885-6222 (Print)en_GB
dc.identifier.issn0885-6222 (Linking)en_GB
dc.identifier.pmid15303243en_GB
dc.identifier.doi10.1002/hup.609en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208948-
dc.description.abstractThe role of cytokines in depression was first considered when the cytokine interferon resulted in "sickness behaviour", the symptoms of which are similar to those of major depression. The latter is associated with an increase in pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-alpha). These cytokines are potent modulators of corticotropin-releasing hormone (CRH) which produces heightened hypothalamic-pituitary-adrenal axis (HPA) activity characterized by increases in ACTH and cortisol, both of which are reported elevated in major depression. Antidepressant treatment has immunomodulatory effects with increases in the production of IL-10, which is an anti-inflammatory cytokine. This review based on a Medline search from 1980-2003, focuses on the evidence available of cytokine changes in acute stress, chronic stress and major depression. It examines the effects of antidepressant treatment on immune parameters in both animal models and clinical trials. We suggest that future antidepressants may target the immune system by either blocking the actions of pro-inflammatory cytokines or increasing the production of anti-inflammatory cytokines.en_GB
dc.language.isoengen_GB
dc.subject.meshAntidepressive Agents/*therapeutic useen_GB
dc.subject.meshCytokines/*metabolismen_GB
dc.subject.meshDepressive Disorder, Major/*drug therapy/immunology/*metabolismen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmune System/metabolismen_GB
dc.subject.meshNeurosecretory Systems/metabolismen_GB
dc.subject.meshSerotonin/metabolismen_GB
dc.subject.meshStress, Physiological/immunology/metabolismen_GB
dc.titleCytokines: abnormalities in major depression and implications for pharmacological treatment.en_GB
dc.contributor.departmentDepartment of Psychiatry, University College Cork, Cork University Hospital,, Wilton Road, Cork, Ireland.en_GB
dc.identifier.journalHuman psychopharmacologyen_GB
dc.description.provinceMunster-

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