Functional dyspepsia (FD) and non-erosive reflux disease (NERD): overlapping or discrete entities?

Hdl Handle:
http://hdl.handle.net/10147/208947
Title:
Functional dyspepsia (FD) and non-erosive reflux disease (NERD): overlapping or discrete entities?
Authors:
Quigley, Eamonn M M
Affiliation:
Department of Medicine, Cork University Hospital, Clinical Sciences Building,, Cork, Ireland. e.quigley@ucc.ie
Citation:
Best Pract Res Clin Gastroenterol. 2004 Aug;18(4):695-706.
Journal:
Best practice & research. Clinical gastroenterology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208947
DOI:
10.1016/j.bpg.2004.04.004
PubMed ID:
15324708
Abstract:
As the incidence of both gastric cancer and peptic ulcer disease have declined, that of gastro-oesophageal reflux disease (GORD) and non-ulcer, or functional dyspepsia (FD) have reached virtually epidemic proportions. As we come to appreciate the expression of these disorders in the community, the real spectrum of each disease has become evident. FD and non-erosive reflux disease (NERD), the most prevalent manifestation of GORD, frequently overlap. Where then does GORD end and FD begin? Is it realistic, or even clinically relevant, to attempt a clear separation between these entities? These are more than issues of mere semantics; therapeutic options may be dictated by the classification of the patient as one or the other. Recent work indicates clearly that NERD is a heterogeneous disorder incorporating some patients who may well harbour subtle manifestations of oesophagitis and others who have entirely normal 24-hour pH studies. These differences may be crucial to the concept of NERD/FD overlap. While evidence in support of this concept is far from complete, it would appear that this overlap is most relevant to those NERD patients who do not exhibit abnormal esophageal acid exposure. These patients truly belong in the spectrum of functional gastrointestinal disorders rather than in GORD; attempts to shoe-horn these individuals into the spectrum of GORD will result in therapeutic disappointment and surgical disaster.
Language:
eng
MeSH:
Diagnosis, Differential; Dyspepsia/diagnosis/epidemiology/*physiopathology/*therapy; Gastroesophageal Reflux/diagnosis/epidemiology/*physiopathology/*therapy; Humans; Prevalence
ISSN:
1521-6918 (Print); 1521-6918 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorQuigley, Eamonn M Men_GB
dc.date.accessioned2012-02-03T15:08:11Z-
dc.date.available2012-02-03T15:08:11Z-
dc.date.issued2012-02-03T15:08:11Z-
dc.identifier.citationBest Pract Res Clin Gastroenterol. 2004 Aug;18(4):695-706.en_GB
dc.identifier.issn1521-6918 (Print)en_GB
dc.identifier.issn1521-6918 (Linking)en_GB
dc.identifier.pmid15324708en_GB
dc.identifier.doi10.1016/j.bpg.2004.04.004en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208947-
dc.description.abstractAs the incidence of both gastric cancer and peptic ulcer disease have declined, that of gastro-oesophageal reflux disease (GORD) and non-ulcer, or functional dyspepsia (FD) have reached virtually epidemic proportions. As we come to appreciate the expression of these disorders in the community, the real spectrum of each disease has become evident. FD and non-erosive reflux disease (NERD), the most prevalent manifestation of GORD, frequently overlap. Where then does GORD end and FD begin? Is it realistic, or even clinically relevant, to attempt a clear separation between these entities? These are more than issues of mere semantics; therapeutic options may be dictated by the classification of the patient as one or the other. Recent work indicates clearly that NERD is a heterogeneous disorder incorporating some patients who may well harbour subtle manifestations of oesophagitis and others who have entirely normal 24-hour pH studies. These differences may be crucial to the concept of NERD/FD overlap. While evidence in support of this concept is far from complete, it would appear that this overlap is most relevant to those NERD patients who do not exhibit abnormal esophageal acid exposure. These patients truly belong in the spectrum of functional gastrointestinal disorders rather than in GORD; attempts to shoe-horn these individuals into the spectrum of GORD will result in therapeutic disappointment and surgical disaster.en_GB
dc.language.isoengen_GB
dc.subject.meshDiagnosis, Differentialen_GB
dc.subject.meshDyspepsia/diagnosis/epidemiology/*physiopathology/*therapyen_GB
dc.subject.meshGastroesophageal Reflux/diagnosis/epidemiology/*physiopathology/*therapyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshPrevalenceen_GB
dc.titleFunctional dyspepsia (FD) and non-erosive reflux disease (NERD): overlapping or discrete entities?en_GB
dc.contributor.departmentDepartment of Medicine, Cork University Hospital, Clinical Sciences Building,, Cork, Ireland. e.quigley@ucc.ieen_GB
dc.identifier.journalBest practice & research. Clinical gastroenterologyen_GB
dc.description.provinceMunster-

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