Perioperative plasma concentrations of stable nitric oxide products are predictive of cognitive dysfunction after laparoscopic cholecystectomy.

Hdl Handle:
http://hdl.handle.net/10147/208946
Title:
Perioperative plasma concentrations of stable nitric oxide products are predictive of cognitive dysfunction after laparoscopic cholecystectomy.
Authors:
Iohom, G; Szarvas, S; Larney, V; O'Brien, J; Buckley, E; Butler, M; Shorten, G
Affiliation:
Department of Anesthesia and Intensive Care Medicine, Cork University Hospital,, Cork, Ireland.
Citation:
Anesth Analg. 2004 Oct;99(4):1245-52, table of contents.
Journal:
Anesthesia and analgesia
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208946
DOI:
10.1213/01.ANE.0000132971.00206.4A
PubMed ID:
15385384
Abstract:
In this study our objectives were to determine the incidence of postoperative cognitive dysfunction (POCD) after laparoscopic cholecystectomy under sevoflurane anesthesia in patients aged >40 and <85 yr and to examine the associations between plasma concentrations of i) S-100beta protein and ii) stable nitric oxide (NO) products and POCD in this clinical setting. Neuropsychological tests were performed on 42 ASA physical status I-II patients the day before, and 4 days and 6 wk after surgery. Patient spouses (n = 13) were studied as controls. Cognitive dysfunction was defined as deficit in one or more cognitive domain(s). Serial measurements of serum concentrations of S-100beta protein and plasma concentrations of stable NO products (nitrate/nitrite, NOx) were performed perioperatively. Four days after surgery, new cognitive deficit was present in 16 (40%) patients and in 1 (7%) control subject (P = 0.01). Six weeks postoperatively, new cognitive deficit was present in 21 (53%) patients and 3 (23%) control subjects (P = 0.03). Compared with the "no deficit" group, patients who demonstrated a new cognitive deficit 4 days postoperatively had larger plasma NOx at each perioperative time point (P < 0.05 for each time point). Serum S-100beta protein concentrations were similar in the 2 groups. In conclusion, preoperative (and postoperative) plasma concentrations of stable NO products (but not S-100beta) are associated with early POCD. The former represents a potential biochemical predictor of POCD.
Language:
eng
MeSH:
Adult; Affect; Aged; Aged, 80 and over; Algorithms; Anesthesia, Inhalation; Anesthetics, Inhalation; Biological Markers; Cholecystectomy, Laparoscopic/*adverse effects; Cognition Disorders/diagnosis/*etiology/*psychology; Depression/psychology; Female; Humans; Male; Memory/drug effects; Methyl Ethers; Middle Aged; Nerve Growth Factors; Neuropsychological Tests; Nitric Oxide/*blood; Postoperative Complications/*etiology/*psychology; Predictive Value of Tests; Psychiatric Status Rating Scales; Psychomotor Performance/drug effects; S100 Proteins/blood; Speech/drug effects; Vasodilator Agents/*blood
ISSN:
0003-2999 (Print); 0003-2999 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorIohom, Gen_GB
dc.contributor.authorSzarvas, Sen_GB
dc.contributor.authorLarney, Ven_GB
dc.contributor.authorO'Brien, Jen_GB
dc.contributor.authorBuckley, Een_GB
dc.contributor.authorButler, Men_GB
dc.contributor.authorShorten, Gen_GB
dc.date.accessioned2012-02-03T15:08:09Z-
dc.date.available2012-02-03T15:08:09Z-
dc.date.issued2012-02-03T15:08:09Z-
dc.identifier.citationAnesth Analg. 2004 Oct;99(4):1245-52, table of contents.en_GB
dc.identifier.issn0003-2999 (Print)en_GB
dc.identifier.issn0003-2999 (Linking)en_GB
dc.identifier.pmid15385384en_GB
dc.identifier.doi10.1213/01.ANE.0000132971.00206.4Aen_GB
dc.identifier.urihttp://hdl.handle.net/10147/208946-
dc.description.abstractIn this study our objectives were to determine the incidence of postoperative cognitive dysfunction (POCD) after laparoscopic cholecystectomy under sevoflurane anesthesia in patients aged >40 and <85 yr and to examine the associations between plasma concentrations of i) S-100beta protein and ii) stable nitric oxide (NO) products and POCD in this clinical setting. Neuropsychological tests were performed on 42 ASA physical status I-II patients the day before, and 4 days and 6 wk after surgery. Patient spouses (n = 13) were studied as controls. Cognitive dysfunction was defined as deficit in one or more cognitive domain(s). Serial measurements of serum concentrations of S-100beta protein and plasma concentrations of stable NO products (nitrate/nitrite, NOx) were performed perioperatively. Four days after surgery, new cognitive deficit was present in 16 (40%) patients and in 1 (7%) control subject (P = 0.01). Six weeks postoperatively, new cognitive deficit was present in 21 (53%) patients and 3 (23%) control subjects (P = 0.03). Compared with the "no deficit" group, patients who demonstrated a new cognitive deficit 4 days postoperatively had larger plasma NOx at each perioperative time point (P < 0.05 for each time point). Serum S-100beta protein concentrations were similar in the 2 groups. In conclusion, preoperative (and postoperative) plasma concentrations of stable NO products (but not S-100beta) are associated with early POCD. The former represents a potential biochemical predictor of POCD.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAffecten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshAlgorithmsen_GB
dc.subject.meshAnesthesia, Inhalationen_GB
dc.subject.meshAnesthetics, Inhalationen_GB
dc.subject.meshBiological Markersen_GB
dc.subject.meshCholecystectomy, Laparoscopic/*adverse effectsen_GB
dc.subject.meshCognition Disorders/diagnosis/*etiology/*psychologyen_GB
dc.subject.meshDepression/psychologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMemory/drug effectsen_GB
dc.subject.meshMethyl Ethersen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshNerve Growth Factorsen_GB
dc.subject.meshNeuropsychological Testsen_GB
dc.subject.meshNitric Oxide/*blooden_GB
dc.subject.meshPostoperative Complications/*etiology/*psychologyen_GB
dc.subject.meshPredictive Value of Testsen_GB
dc.subject.meshPsychiatric Status Rating Scalesen_GB
dc.subject.meshPsychomotor Performance/drug effectsen_GB
dc.subject.meshS100 Proteins/blooden_GB
dc.subject.meshSpeech/drug effectsen_GB
dc.subject.meshVasodilator Agents/*blooden_GB
dc.titlePerioperative plasma concentrations of stable nitric oxide products are predictive of cognitive dysfunction after laparoscopic cholecystectomy.en_GB
dc.contributor.departmentDepartment of Anesthesia and Intensive Care Medicine, Cork University Hospital,, Cork, Ireland.en_GB
dc.identifier.journalAnesthesia and analgesiaen_GB
dc.description.provinceMunster-

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