Subclinical anaemia of chronic disease in adult patients with cystic fibrosis.

Hdl Handle:
http://hdl.handle.net/10147/208945
Title:
Subclinical anaemia of chronic disease in adult patients with cystic fibrosis.
Authors:
O'connor, T M; McGrath, D S; Short, C; O'donnell, M J; Sheehy, M; Bredin, C P
Affiliation:
Regional Adult Cystic Fibrosis Unit, Department of Respiratory Medicine, Cork, University Hospital, Wilton, Cork, Ireland. terryoconnor@eircom.net
Citation:
J Cyst Fibros. 2002 Mar;1(1):31-4.
Journal:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis, Society
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208945
PubMed ID:
15463807
Abstract:
Patients with chronic hypoxaemia develop secondary polycythaemia that improves oxygen-carrying capacity. Therefore, normal haemoglobin and haematocrit values in the presence of chronic arterial hypoxaemia in cystic fibrosis constitute 'relative anaemia'. We sought to determine the cause of this relative anaemia in patients with cystic fibrosis. We studied haematological indices and oxygen saturation in healthy volunteers (n=17) and in adult patients with cystic fibrosis (n=15). Patients with cystic fibrosis had lower resting arterial oxygen saturation when compared with normal volunteers (P<0.0001), and exercise led to a greater reduction in arterial oxygen saturation (P<0.0001). However, haemoglobin and haematocrit values in patients with cystic fibrosis did not significantly differ from normal volunteers. Serum iron (P=0.002), transferrin (P=0.02), and total iron-binding capacity (P=0.01) were lower in patients with cystic fibrosis. There were no significant differences in serum ferritin, percentage iron saturation, serum erythropoietin or red cell volume between the groups. The data presented demonstrate a characteristic picture of anaemia of chronic disease in adult patients with cystic fibrosis, except for normal haemoglobin and haematocrit values. Normal haemoglobin and haematocrit values in patients with cystic fibrosis appear to represent a combination of the effects of arterial hypoxaemia promoting polycythaemia, counterbalanced by chronic inflammation promoting anaemia of chronic disease.
Language:
eng
MeSH:
Adult; Anemia/blood/*etiology; Anemia, Iron-Deficiency/etiology; Anoxia/etiology; Chronic Disease; Cystic Fibrosis/blood/*complications; Hematologic Tests; Humans; Oxygen/*blood; Polycythemia/etiology
ISSN:
1569-1993 (Print); 1569-1993 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorO'connor, T Men_GB
dc.contributor.authorMcGrath, D Sen_GB
dc.contributor.authorShort, Cen_GB
dc.contributor.authorO'donnell, M Jen_GB
dc.contributor.authorSheehy, Men_GB
dc.contributor.authorBredin, C Pen_GB
dc.date.accessioned2012-02-03T15:08:07Z-
dc.date.available2012-02-03T15:08:07Z-
dc.date.issued2012-02-03T15:08:07Z-
dc.identifier.citationJ Cyst Fibros. 2002 Mar;1(1):31-4.en_GB
dc.identifier.issn1569-1993 (Print)en_GB
dc.identifier.issn1569-1993 (Linking)en_GB
dc.identifier.pmid15463807en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208945-
dc.description.abstractPatients with chronic hypoxaemia develop secondary polycythaemia that improves oxygen-carrying capacity. Therefore, normal haemoglobin and haematocrit values in the presence of chronic arterial hypoxaemia in cystic fibrosis constitute 'relative anaemia'. We sought to determine the cause of this relative anaemia in patients with cystic fibrosis. We studied haematological indices and oxygen saturation in healthy volunteers (n=17) and in adult patients with cystic fibrosis (n=15). Patients with cystic fibrosis had lower resting arterial oxygen saturation when compared with normal volunteers (P<0.0001), and exercise led to a greater reduction in arterial oxygen saturation (P<0.0001). However, haemoglobin and haematocrit values in patients with cystic fibrosis did not significantly differ from normal volunteers. Serum iron (P=0.002), transferrin (P=0.02), and total iron-binding capacity (P=0.01) were lower in patients with cystic fibrosis. There were no significant differences in serum ferritin, percentage iron saturation, serum erythropoietin or red cell volume between the groups. The data presented demonstrate a characteristic picture of anaemia of chronic disease in adult patients with cystic fibrosis, except for normal haemoglobin and haematocrit values. Normal haemoglobin and haematocrit values in patients with cystic fibrosis appear to represent a combination of the effects of arterial hypoxaemia promoting polycythaemia, counterbalanced by chronic inflammation promoting anaemia of chronic disease.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnemia/blood/*etiologyen_GB
dc.subject.meshAnemia, Iron-Deficiency/etiologyen_GB
dc.subject.meshAnoxia/etiologyen_GB
dc.subject.meshChronic Diseaseen_GB
dc.subject.meshCystic Fibrosis/blood/*complicationsen_GB
dc.subject.meshHematologic Testsen_GB
dc.subject.meshHumansen_GB
dc.subject.meshOxygen/*blooden_GB
dc.subject.meshPolycythemia/etiologyen_GB
dc.titleSubclinical anaemia of chronic disease in adult patients with cystic fibrosis.en_GB
dc.contributor.departmentRegional Adult Cystic Fibrosis Unit, Department of Respiratory Medicine, Cork, University Hospital, Wilton, Cork, Ireland. terryoconnor@eircom.neten_GB
dc.identifier.journalJournal of cystic fibrosis : official journal of the European Cystic Fibrosis, Societyen_GB
dc.description.provinceMunster-

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