Review article: gastric emptying in functional gastrointestinal disorders.

Hdl Handle:
http://hdl.handle.net/10147/208939
Title:
Review article: gastric emptying in functional gastrointestinal disorders.
Authors:
Quigley, E M M
Affiliation:
Department of Medicine, Cork University Hospital, Cork, Ireland. equigley@ucc.ie
Citation:
Aliment Pharmacol Ther. 2004 Nov;20 Suppl 7:56-60.
Journal:
Alimentary pharmacology & therapeutics
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208939
DOI:
10.1111/j.1365-2036.2004.02186.x
PubMed ID:
15521856
Abstract:
Although delayed gastric emptying has been described in several functional gastrointestinal disorders, and appears to be especially common in functional dyspepsia, the relationship of this finding to symptoms and basic pathophysiology is difficult to define. The delineation of the interactions between delayed gastric emptying, on the one hand, and symptom pathogenesis, on the other, has been hampered by several factors. These include the limitations of the methodology itself, the extent of overlap between the various functional disorders and the sensitivity of gastric emptying to factors external to the stomach, be they elsewhere within the gastrointestinal tract, in the central nervous system or in the environment. In many instances, delayed gastric emptying is an epiphenomenon, reflecting the overlap between inadequately defined functional syndromes, shared pathophysiology or the activation of physiological interactions between the various organs of the gut. In others, it may imply a truly diffuse motor disorder. The disappointments attendant on attempts to alleviate symptoms through approaches designed to accelerate gastric emptying should therefore not come as a surprise. Pending the definition of the true significance of delayed gastric emptying in all functional gastrointestinal disorders, caution should be exerted in the interpretation of this finding in a patient with functional symptoms.
Language:
eng
MeSH:
Autonomic Nervous System Diseases/complications/physiopathology; Central Nervous System Diseases/complications/physiopathology; Enteric Nervous System/physiology; Gastric Emptying/*physiology; Gastrointestinal Diseases/etiology/*physiopathology; Humans
ISSN:
0269-2813 (Print); 0269-2813 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorQuigley, E M Men_GB
dc.date.accessioned2012-02-03T15:07:58Z-
dc.date.available2012-02-03T15:07:58Z-
dc.date.issued2012-02-03T15:07:58Z-
dc.identifier.citationAliment Pharmacol Ther. 2004 Nov;20 Suppl 7:56-60.en_GB
dc.identifier.issn0269-2813 (Print)en_GB
dc.identifier.issn0269-2813 (Linking)en_GB
dc.identifier.pmid15521856en_GB
dc.identifier.doi10.1111/j.1365-2036.2004.02186.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/208939-
dc.description.abstractAlthough delayed gastric emptying has been described in several functional gastrointestinal disorders, and appears to be especially common in functional dyspepsia, the relationship of this finding to symptoms and basic pathophysiology is difficult to define. The delineation of the interactions between delayed gastric emptying, on the one hand, and symptom pathogenesis, on the other, has been hampered by several factors. These include the limitations of the methodology itself, the extent of overlap between the various functional disorders and the sensitivity of gastric emptying to factors external to the stomach, be they elsewhere within the gastrointestinal tract, in the central nervous system or in the environment. In many instances, delayed gastric emptying is an epiphenomenon, reflecting the overlap between inadequately defined functional syndromes, shared pathophysiology or the activation of physiological interactions between the various organs of the gut. In others, it may imply a truly diffuse motor disorder. The disappointments attendant on attempts to alleviate symptoms through approaches designed to accelerate gastric emptying should therefore not come as a surprise. Pending the definition of the true significance of delayed gastric emptying in all functional gastrointestinal disorders, caution should be exerted in the interpretation of this finding in a patient with functional symptoms.en_GB
dc.language.isoengen_GB
dc.subject.meshAutonomic Nervous System Diseases/complications/physiopathologyen_GB
dc.subject.meshCentral Nervous System Diseases/complications/physiopathologyen_GB
dc.subject.meshEnteric Nervous System/physiologyen_GB
dc.subject.meshGastric Emptying/*physiologyen_GB
dc.subject.meshGastrointestinal Diseases/etiology/*physiopathologyen_GB
dc.subject.meshHumansen_GB
dc.titleReview article: gastric emptying in functional gastrointestinal disorders.en_GB
dc.contributor.departmentDepartment of Medicine, Cork University Hospital, Cork, Ireland. equigley@ucc.ieen_GB
dc.identifier.journalAlimentary pharmacology & therapeuticsen_GB
dc.description.provinceMunster-

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