Intravenous but not perineural clonidine prolongs postoperative analgesia after psoas compartment block with 0.5% levobupivacaine for hip fracture surgery.

Hdl Handle:
http://hdl.handle.net/10147/208922
Title:
Intravenous but not perineural clonidine prolongs postoperative analgesia after psoas compartment block with 0.5% levobupivacaine for hip fracture surgery.
Authors:
Mannion, Stephen; Hayes, Ivan; Loughnane, Frank; Murphy, Damian B; Shorten, George D
Affiliation:
Department of Anaesthesia and Intensive Care, Cork University Hospital, Cork,, Ireland. mannionstephen@hotmail.com
Citation:
Anesth Analg. 2005 Mar;100(3):873-8, table of contents.
Journal:
Anesthesia and analgesia
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208922
DOI:
10.1213/01.ANE.0000143950.13939.7A
PubMed ID:
15728081
Abstract:
We evaluated the systemic and local effects of clonidine as an analgesic adjunct to psoas compartment block (PCB) with levobupivacaine. In a randomized, prospective, double-blind trial, 36 patients requiring hip fracture surgery received PCB and general anesthesia. Patients were randomized into three groups. Each patient received PCB with 0.4 mL/kg of levobupivacaine 0.5%. The control group (group L) received IV saline, the systemic clonidine group (group IC) received IV clonidine 1 mug/kg, and the peripheral clonidine group (group C) received IV saline and PCB with clonidine 1 microg/kg. The interval from time of completion of block injection to first supplementary analgesic administration was longer in group IC compared with group L (mean +/- sd, 13.4 +/- 6.1 versus 7.3 +/- 3.6 h; P = 0.03). There was no difference between group C and group L (10.3 +/- 5.9 versus 7.3 +/- 3.6 h; P > 0.05). The groups were similar in terms of 24 h cumulative morphine and acetaminophen consumption. There were no significant differences among groups regarding postoperative adverse effects (bradycardia, hypotension, sedation, and nausea). We conclude that IV but not perineural clonidine (1 microg/kg) prolongs analgesia after PCB without increasing the incidence of adverse effects.
Language:
eng
MeSH:
Aged; Aged, 80 and over; Bupivacaine/analogs & derivatives/*pharmacology; Clonidine/*administration & dosage/adverse effects/pharmacokinetics; Double-Blind Method; Female; Hip Fractures/*surgery; Humans; Infusions, Intravenous; *Lumbosacral Plexus; Male; Middle Aged; *Nerve Block; Pain, Postoperative/*drug therapy; Prospective Studies; Psoas Muscles/innervation
ISSN:
0003-2999 (Print); 0003-2999 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMannion, Stephenen_GB
dc.contributor.authorHayes, Ivanen_GB
dc.contributor.authorLoughnane, Franken_GB
dc.contributor.authorMurphy, Damian Ben_GB
dc.contributor.authorShorten, George Den_GB
dc.date.accessioned2012-02-03T15:07:30Z-
dc.date.available2012-02-03T15:07:30Z-
dc.date.issued2012-02-03T15:07:30Z-
dc.identifier.citationAnesth Analg. 2005 Mar;100(3):873-8, table of contents.en_GB
dc.identifier.issn0003-2999 (Print)en_GB
dc.identifier.issn0003-2999 (Linking)en_GB
dc.identifier.pmid15728081en_GB
dc.identifier.doi10.1213/01.ANE.0000143950.13939.7Aen_GB
dc.identifier.urihttp://hdl.handle.net/10147/208922-
dc.description.abstractWe evaluated the systemic and local effects of clonidine as an analgesic adjunct to psoas compartment block (PCB) with levobupivacaine. In a randomized, prospective, double-blind trial, 36 patients requiring hip fracture surgery received PCB and general anesthesia. Patients were randomized into three groups. Each patient received PCB with 0.4 mL/kg of levobupivacaine 0.5%. The control group (group L) received IV saline, the systemic clonidine group (group IC) received IV clonidine 1 mug/kg, and the peripheral clonidine group (group C) received IV saline and PCB with clonidine 1 microg/kg. The interval from time of completion of block injection to first supplementary analgesic administration was longer in group IC compared with group L (mean +/- sd, 13.4 +/- 6.1 versus 7.3 +/- 3.6 h; P = 0.03). There was no difference between group C and group L (10.3 +/- 5.9 versus 7.3 +/- 3.6 h; P > 0.05). The groups were similar in terms of 24 h cumulative morphine and acetaminophen consumption. There were no significant differences among groups regarding postoperative adverse effects (bradycardia, hypotension, sedation, and nausea). We conclude that IV but not perineural clonidine (1 microg/kg) prolongs analgesia after PCB without increasing the incidence of adverse effects.en_GB
dc.language.isoengen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshBupivacaine/analogs & derivatives/*pharmacologyen_GB
dc.subject.meshClonidine/*administration & dosage/adverse effects/pharmacokineticsen_GB
dc.subject.meshDouble-Blind Methoden_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHip Fractures/*surgeryen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfusions, Intravenousen_GB
dc.subject.mesh*Lumbosacral Plexusen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.mesh*Nerve Blocken_GB
dc.subject.meshPain, Postoperative/*drug therapyen_GB
dc.subject.meshProspective Studiesen_GB
dc.subject.meshPsoas Muscles/innervationen_GB
dc.titleIntravenous but not perineural clonidine prolongs postoperative analgesia after psoas compartment block with 0.5% levobupivacaine for hip fracture surgery.en_GB
dc.contributor.departmentDepartment of Anaesthesia and Intensive Care, Cork University Hospital, Cork,, Ireland. mannionstephen@hotmail.comen_GB
dc.identifier.journalAnesthesia and analgesiaen_GB
dc.description.provinceMunster-
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.