Advanced Merkel cell cancer and the elderly.

Hdl Handle:
http://hdl.handle.net/10147/208912
Title:
Advanced Merkel cell cancer and the elderly.
Authors:
Bird, B R; Myers, D; Ryan, S M; Wyse, G; O'Sullivan, S T; Breathnach, O S
Affiliation:
Department of Medical Oncology, Cork University Hospital, Wilton, Cork., brianbird@eircom.net
Citation:
Ir J Med Sci. 2005 Jan-Mar;174(1):58-60.
Journal:
Irish journal of medical science
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208912
PubMed ID:
15868892
Abstract:
BACKGROUND: Merkel cell cancer (MCC) is an uncommon neuroendocrine skin cancer occurring predominantly in elderly Caucasians. It tends to metastasize to regional lymph nodes and viscera and is sensitive to chemotherapy but recurs rapidly. AIM: To report one such case, its response to chemotherapy and briefly review the literature. METHODS: A 73-year-old male with a fungating primary lesion on his left knee and ulcerated inguinal lymph nodes was diagnosed with MCC and treated with chemotherapy. The two largest case series and reviews of case reports were summarised. RESULTS: His ulcer healed after two cycles of carboplatin and etoposide with improvement in quality of life. Overall response rates of nearly 60% to chemotherapy are reported but median survival is only nine months with metastatic disease. CONCLUSIONS: Chemotherapy should be considered for fit elderly patients with MCC who have recurrent or advanced disease.
Language:
eng
MeSH:
Aged; Antineoplastic Agents/*therapeutic use; Carboplatin/*therapeutic use; Carcinoma, Merkel Cell/diagnosis/*drug therapy; Disease Progression; Etoposide/*therapeutic use; Groin/pathology; Humans; Knee/pathology; Male; Neoplasm Staging; Skin Neoplasms/diagnosis/*drug therapy
ISSN:
0021-1265 (Print); 0021-1265 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorBird, B Ren_GB
dc.contributor.authorMyers, Den_GB
dc.contributor.authorRyan, S Men_GB
dc.contributor.authorWyse, Gen_GB
dc.contributor.authorO'Sullivan, S Ten_GB
dc.contributor.authorBreathnach, O Sen_GB
dc.date.accessioned2012-02-03T15:07:13Z-
dc.date.available2012-02-03T15:07:13Z-
dc.date.issued2012-02-03T15:07:13Z-
dc.identifier.citationIr J Med Sci. 2005 Jan-Mar;174(1):58-60.en_GB
dc.identifier.issn0021-1265 (Print)en_GB
dc.identifier.issn0021-1265 (Linking)en_GB
dc.identifier.pmid15868892en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208912-
dc.description.abstractBACKGROUND: Merkel cell cancer (MCC) is an uncommon neuroendocrine skin cancer occurring predominantly in elderly Caucasians. It tends to metastasize to regional lymph nodes and viscera and is sensitive to chemotherapy but recurs rapidly. AIM: To report one such case, its response to chemotherapy and briefly review the literature. METHODS: A 73-year-old male with a fungating primary lesion on his left knee and ulcerated inguinal lymph nodes was diagnosed with MCC and treated with chemotherapy. The two largest case series and reviews of case reports were summarised. RESULTS: His ulcer healed after two cycles of carboplatin and etoposide with improvement in quality of life. Overall response rates of nearly 60% to chemotherapy are reported but median survival is only nine months with metastatic disease. CONCLUSIONS: Chemotherapy should be considered for fit elderly patients with MCC who have recurrent or advanced disease.en_GB
dc.language.isoengen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAntineoplastic Agents/*therapeutic useen_GB
dc.subject.meshCarboplatin/*therapeutic useen_GB
dc.subject.meshCarcinoma, Merkel Cell/diagnosis/*drug therapyen_GB
dc.subject.meshDisease Progressionen_GB
dc.subject.meshEtoposide/*therapeutic useen_GB
dc.subject.meshGroin/pathologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshKnee/pathologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshNeoplasm Stagingen_GB
dc.subject.meshSkin Neoplasms/diagnosis/*drug therapyen_GB
dc.titleAdvanced Merkel cell cancer and the elderly.en_GB
dc.contributor.departmentDepartment of Medical Oncology, Cork University Hospital, Wilton, Cork., brianbird@eircom.neten_GB
dc.identifier.journalIrish journal of medical scienceen_GB
dc.description.provinceMunster-

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