Anatomy of melancholia: focus on hypothalamic-pituitary-adrenal axis overactivity and the role of vasopressin.

Hdl Handle:
http://hdl.handle.net/10147/208886
Title:
Anatomy of melancholia: focus on hypothalamic-pituitary-adrenal axis overactivity and the role of vasopressin.
Authors:
Dinan, Timothy G; Scott, Lucinda V
Affiliation:
Department of Psychiatry and Alimentary Pharmabiotic Centre, Cork University, Hospital, Ireland. t.dinan@ucc.ie
Citation:
J Anat. 2005 Sep;207(3):259-64.
Journal:
Journal of anatomy
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208886
DOI:
10.1111/j.1469-7580.2005.00443.x
PubMed ID:
16185250
Abstract:
Overactivity of the hypothalamic-pituitary-adrenal (HPA) axis characterized by hypercortisolism, adrenal hyperplasia and abnormalities in negative feedback is the most consistently described biological abnormality in melancholic depression. Corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are the main secretagogues of the HPA/stress system. Produced in the parvicellular division of the hypothalamic paraventricular nucleus the release of these peptides is influenced by inputs from monoaminergic neurones. In depression, anterior pituitary CRH1 receptors are down-regulated and response to CRH infusion is blunted. By contrast, vasopressin V3 receptors on the anterior pituitary show enhanced response to AVP stimulation and this enhancement plays a key role in maintaining HPA overactivity.
Language:
eng
MeSH:
Adrenocorticotropic Hormone/physiology; Depressive Disorder/*physiopathology; Feedback, Physiological; Glucocorticoids/physiology; Humans; Hydrocortisone/physiology; Hypothalamo-Hypophyseal System/*physiology; Neurons/metabolism; Pituitary-Adrenal System/*physiology; Receptors, Vasopressin/metabolism; Stress, Psychological; Vasopressins/*physiology
ISSN:
0021-8782 (Print); 0021-8782 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorDinan, Timothy Gen_GB
dc.contributor.authorScott, Lucinda Ven_GB
dc.date.accessioned2012-02-03T15:06:29Z-
dc.date.available2012-02-03T15:06:29Z-
dc.date.issued2012-02-03T15:06:29Z-
dc.identifier.citationJ Anat. 2005 Sep;207(3):259-64.en_GB
dc.identifier.issn0021-8782 (Print)en_GB
dc.identifier.issn0021-8782 (Linking)en_GB
dc.identifier.pmid16185250en_GB
dc.identifier.doi10.1111/j.1469-7580.2005.00443.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/208886-
dc.description.abstractOveractivity of the hypothalamic-pituitary-adrenal (HPA) axis characterized by hypercortisolism, adrenal hyperplasia and abnormalities in negative feedback is the most consistently described biological abnormality in melancholic depression. Corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are the main secretagogues of the HPA/stress system. Produced in the parvicellular division of the hypothalamic paraventricular nucleus the release of these peptides is influenced by inputs from monoaminergic neurones. In depression, anterior pituitary CRH1 receptors are down-regulated and response to CRH infusion is blunted. By contrast, vasopressin V3 receptors on the anterior pituitary show enhanced response to AVP stimulation and this enhancement plays a key role in maintaining HPA overactivity.en_GB
dc.language.isoengen_GB
dc.subject.meshAdrenocorticotropic Hormone/physiologyen_GB
dc.subject.meshDepressive Disorder/*physiopathologyen_GB
dc.subject.meshFeedback, Physiologicalen_GB
dc.subject.meshGlucocorticoids/physiologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHydrocortisone/physiologyen_GB
dc.subject.meshHypothalamo-Hypophyseal System/*physiologyen_GB
dc.subject.meshNeurons/metabolismen_GB
dc.subject.meshPituitary-Adrenal System/*physiologyen_GB
dc.subject.meshReceptors, Vasopressin/metabolismen_GB
dc.subject.meshStress, Psychologicalen_GB
dc.subject.meshVasopressins/*physiologyen_GB
dc.titleAnatomy of melancholia: focus on hypothalamic-pituitary-adrenal axis overactivity and the role of vasopressin.en_GB
dc.contributor.departmentDepartment of Psychiatry and Alimentary Pharmabiotic Centre, Cork University, Hospital, Ireland. t.dinan@ucc.ieen_GB
dc.identifier.journalJournal of anatomyen_GB
dc.description.provinceMunster-
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